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Author:
Publisher:
Published: 1992
Total Pages: 742
ISBN-13:
DOWNLOAD EBOOKPublishes original reports of studies in all areas of abnormal development and related fields. It also welcomes reviews of topics of current significance and letters discussing papers that have appeard in Teratology or that deal with controversial scientific matters of interest to its readers.
Author: Thomas H. Shepard
Publisher: JHU Press
Published: 2004
Total Pages: 564
ISBN-13: 9780801879531
DOWNLOAD EBOOKLinks information on experimental teratogenic agents with the congenital defects in human beings.
Author: James Graves Wilson
Publisher:
Published: 1973
Total Pages: 328
ISBN-13:
DOWNLOAD EBOOKAuthor: T.V.N. Persaud
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 240
ISBN-13: 9401159106
DOWNLOAD EBOOKThe study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.
Author: Paul C. Barrow
Publisher: Humana Press
Published: 2012-11-09
Total Pages: 0
ISBN-13: 9781627031301
DOWNLOAD EBOOKTeratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.
Author: James Graves Wilson
Publisher:
Published: 1965
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOKAuthor: H. Kalter
Publisher: Elsevier
Published: 2003-06-06
Total Pages: 167
ISBN-13: 0080542352
DOWNLOAD EBOOKThis book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.
Author: Frederick A. Jakobiec
Publisher: HarperCollins Publishers
Published: 1982
Total Pages: 1172
ISBN-13:
DOWNLOAD EBOOKAuthor: T.V.N. Persaud
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 357
ISBN-13: 940116651X
DOWNLOAD EBOOKThe study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato logical evaluation and the use of selected animal models for the study of con genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.
