Ten Drugs

Ten Drugs

Author: Thomas Hager

Publisher: Abrams

Published: 2019-03-05

Total Pages: 342

ISBN-13: 1683355318

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“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History


Ten Drugs

Ten Drugs

Author: Thomas Hager

Publisher: Harry N. Abrams

Published: 2019-03-05

Total Pages: 0

ISBN-13: 9781419734403

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Beginning with opium, the "joy plant," which has been used for 10,000 years, Hager's subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain; the infamous knockout drops; the first antibiotic, which saved countless lives; the first antipsychotic, which helped empty public mental hospitals; Viagra, statins; and the new frontier of monoclonal antibodies.


Top Drugs

Top Drugs

Author: Jie Jack Li

Publisher: Oxford University Press

Published: 2015-07-31

Total Pages: 219

ISBN-13: 0199362602

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Drugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today's medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery. Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one's creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug's discovery. Li begins each chapter with the product's history, providing necessary context. Li then proceeds to describe the mechanism of action, structure-activity relationship (SAR), bioavailability, metabolism, toxicology, the discovery route, and the process route. Top Drugs: Their History, Pharmacology, and Synthesis will acclimate students, scientists, and interested laypersons to the world of chemistry and drug discovery.


Cholesterol Down

Cholesterol Down

Author: Janet Bond Brill, PhD, RD, LDN

Publisher: Harmony

Published: 2009-01-21

Total Pages: 338

ISBN-13: 0307494462

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Take control of your cholesterol with this 10-point plan from nutrition and fitness expert Dr. Janet Brill—without using drugs. If you are one of the nearly 100 million Americans struggling with high cholesterol, then Dr. Janet Brill offers you a revolutionary new plan for taking control of your health—without the risks of statin drugs. With Dr. Brill’s breakthrough Cholesterol Down Plan, you simply add nine “miracle foods” to your regular diet and thirty minutes of walking to your daily routine. That’s all. This straightforward and easy-to-follow program can lower your LDL (“bad”) cholesterol by as much as 47 percent in just four weeks. Cholesterol Down explains Dr. Brill’s ten-point plan as well as the science behind it. You’ll learn how each miracle food affects LDL cholesterol and how the foods work together for maximum effect, as well as: • How eating whole grains helps reduce LDL cholesterol in your bloodstream • Why antioxidants keep plaque from building up in your arteries • How certain steps change the structure of LDL cholesterol particles (and why it’s best for them to be large and fluffy) • Why walking just thirty minutes a day lowers “bad” cholesterol and cuts dangerous belly fat With everything you need to stay focused on the plan, including a daily checklist, a six-month chart for racking LDL cholesterol changes, tools for assessing your risk level for cardiovascular disease, sample weekly menus, and even heart-healthy recipes, Cholesterol Down is the safe and effective alternative or complement to statin drugs.


Chiral Drugs

Chiral Drugs

Author: Guo-Qiang Lin

Publisher: John Wiley & Sons

Published: 2011-08-08

Total Pages: 469

ISBN-13: 1118075633

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An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.


Making Medicines Affordable

Making Medicines Affordable

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2018-03-01

Total Pages: 235

ISBN-13: 0309468086

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Thanks to remarkable advances in modern health care attributable to science, engineering, and medicine, it is now possible to cure or manage illnesses that were long deemed untreatable. At the same time, however, the United States is facing the vexing challenge of a seemingly uncontrolled rise in the cost of health care. Total medical expenditures are rapidly approaching 20 percent of the gross domestic product and are crowding out other priorities of national importance. The use of increasingly expensive prescription drugs is a significant part of this problem, making the cost of biopharmaceuticals a serious national concern with broad political implications. Especially with the highly visible and very large price increases for prescription drugs that have occurred in recent years, finding a way to make prescription medicinesâ€"and health care at largeâ€"more affordable for everyone has become a socioeconomic imperative. Affordability is a complex function of factors, including not just the prices of the drugs themselves, but also the details of an individual's insurance coverage and the number of medical conditions that an individual or family confronts. Therefore, any solution to the affordability issue will require considering all of these factors together. The current high and increasing costs of prescription drugsâ€"coupled with the broader trends in overall health care costsâ€"is unsustainable to society as a whole. Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. This report explores structural and policy factors influencing drug pricing, drug access programs, the emerging role of comparative effectiveness assessments in payment policies, changing finances of medical practice with regard to drug costs and reimbursement, and measures to prevent drug shortages and foster continued innovation in drug development. It makes recommendations for policy actions that could address drug price trends, improve patient access to affordable and effective treatments, and encourage innovations that address significant needs in health care.


Random Family

Random Family

Author: Adrian Nicole LeBlanc

Publisher: Simon and Schuster

Published: 2012-10-23

Total Pages: 436

ISBN-13: 1439124892

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Selected as One of the Best Books of the 21st Century by The New York Times Set amid the havoc of the War on Drugs, this New York Times bestseller is an "astonishingly intimate" (New York magazine) chronicle of one family’s triumphs and trials in the South Bronx of the 1990s. “Unmatched in depth and power and grace. A profound, achingly beautiful work of narrative nonfiction…The standard-bearer of embedded reportage.” —Matthew Desmond, author of Evicted In her classic bestseller, journalist Adrian Nicole LeBlanc immerses readers in the world of one family with roots in the Bronx, New York. In 1989, LeBlanc approached Jessica, a young mother whose encounter with the carceral state is about to forever change the direction of her life. This meeting redirected LeBlanc’s reporting, taking her past the perennial stories of crime and violence into the community of women and children who bear the brunt of the insidious violence of poverty. Her book bears witness to the teetering highs and devastating lows in the daily lives of Jessica, her family, and her expanding circle of friends. Set at the height of the War on Drugs, Random Family is a love story—an ode to the families that form us and the families we create for ourselves. Charting the tumultuous struggle of hope against deprivation over three generations, LeBlanc slips behind the statistics and comes back with a riveting, haunting, and distinctly American true story.


The Demon Under the Microscope

The Demon Under the Microscope

Author: Thomas Hager

Publisher: Crown

Published: 2006-09-19

Total Pages: 354

ISBN-13: 0307352285

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In The Demon Under the Microscope, Thomas Hager chronicles the dramatic history of sulfa, the first antibiotic and the drug that shaped modern medicine. The Nazis discovered it. The Allies won the war with it. It conquered diseases, changed laws, and single-handedly launched the era of antibiotics. Sulfa saved millions of lives—among them those of Winston Churchill and Franklin Delano Roosevelt Jr.—but its real effects are even more far reaching. Sulfa changed the way new drugs were developed, approved, and sold; transformed the way doctors treated patients; and ushered in the era of modern medicine. The very concept that chemicals created in a lab could cure disease revolutionized medicine, taking it from the treatment of symptoms and discomfort to the eradication of the root cause of illness. A strange and colorful story, The Demon Under the Microscope illuminates the vivid characters, corporate strategy, individual idealism, careful planning, lucky breaks, cynicism, heroism, greed, hard work, and the central (though mistaken) idea that brought sulfa to the world. This is a fascinating scientific tale with all the excitement and intrigue of a great suspense novel.


Drugs 101, 2nd Edition

Drugs 101, 2nd Edition

Author: Margaret O. Hyde

Publisher: Twenty-First Century Books

Published: 2013-01-01

Total Pages: 152

ISBN-13: 0761326375

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What are illicit drugs? Why do people use them? What are the effects on the body of using drugs? Are some drugs more dangerous than others? What is addiction? Why are some people able to stop using drugs at will while others become addicted? Respected science author Magaret O. Hyde and Yale University School of Medicine physician John F. Setaro take a fresh approach to the problem of drug abuse among teens. This book looks at drugs and drug abuse honestly and realistically, from a review of the intoxicating and health effects of drugs to the war on drugs to the debate over legalization. The authors' straightforward descriptions of the physical, psychological, social, and legal effects of drug use will be highly informative to those teens in the process of making a decision of about drugs. The book will also benefit the one out of ten American teens who have already used drugs-and will be invaluable to the many for whom drugs have become a dependency. A self test for drug dependency and a list of website for organizations that can provide further information and assistance complete this practical, teen-friendly guide.