Technical Report on Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Technical Report on Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Author: R. D. Irwin

Publisher: DIANE Publishing

Published: 2009-02

Total Pages: 174

ISBN-13: 1437908292

DOWNLOAD EBOOK

Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. Groups of 50 animals received 20, 40, or 80 milligrams of formamide per kilogram body weight 5 days per week for 2 years; groups of animals receiving water alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The only effects observed in male and female rats were lower body weight in animals receiving the highest dose of formamide and a slight increase in bone marrow hyperplasia in male rats. The study concludes that exposure to formamide did not cause cancer in male or female rats, but it did produce hemangiosarcomas in the liver of male mice and may have been related to an increase in liver tumors in female mice. Increased incidence of bone marrow hyperplasia in male rats and testicular mineralization in male mice were also associated with formamide exposure. Illus.

Understanding Toxicology
Understanding Toxicology

Author: Mercurio

Publisher: Jones & Bartlett Publishers

Published: 2016-08-30

Total Pages: 973

ISBN-13: 0763771163

DOWNLOAD EBOOK

Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter

Reporting for the Domestic Substances List
Reporting for the Domestic Substances List

Author: Canada. Environment Canada

Publisher:

Published: 1988

Total Pages: 128

ISBN-13:

DOWNLOAD EBOOK

The Canadian Environmental Protection Act (CEPA) provides the legislative basis for addressing pollution problems on land, in water and through all layers of the atmosphere. It establishes a comprehensive framework to manage toxic substances through their life cycle, from development and manufacture, through transport, distribution, use and storage, to safe disposal as waste. This guide gives information on the CEPA, the domestic and non-domestic substances list and amendments to it; criteria for reporting; how to report; guidelines to substance reporting; confidentiality; and problem letters. The guide also includes relevant sections of CEPA and definitions of terms.

Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances
Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances

Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Publisher: World Health Organization

Published: 1999

Total Pages: 696

ISBN-13:

DOWNLOAD EBOOK

Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine

Hepatotoxicity
Hepatotoxicity

Author: Hyman J. Zimmerman

Publisher: Lippincott Williams & Wilkins

Published: 1999

Total Pages: 850

ISBN-13: 9780781719520

DOWNLOAD EBOOK

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.