Technical Report on Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Technical Report on Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Author: P. C. Chan

Publisher: DIANE Publishing

Published: 2009-09

Total Pages: 206

ISBN-13: 1437914543

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Cumene is produced in a modified Friedel-Crafts reaction process. Cumene is the principal chemical used in the production of phenol and acetone. Cumene is used: as a thinner; as a constituent of some petroleum-based solvents; in gasoline blending, diesel fuel, and high-octane aviation fuel; and as a raw material for peroxides and oxidation catalysts. Because cumene is a good solvent for fats and resins, it has been suggested as a replacement for benzene in many industrial applications. Cumene occurs naturally in petroleum and in a variety of foodstuffs. Cumene was nominated for study because of its high production volume, presence in gasoline and other fuels, potential for human exposure, and lack of existing carcinogenecity test data. Illus.

Boorman's Pathology of the Rat
Boorman's Pathology of the Rat

Author: Andrew W. Suttie

Publisher: Academic Press

Published: 2017-12-01

Total Pages: 750

ISBN-13: 0123914892

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Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

Technical Report on Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Technical Report on Toxicology and Carcinogenesis Studies of Formamide (CAS No. 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Author: R. D. Irwin

Publisher: DIANE Publishing

Published: 2009-02

Total Pages: 174

ISBN-13: 1437908292

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Formamide has a variety of uses, including as a softener for paper, gums, and glues. This report details the study of the effects of formamide on male and female rats and mice to identify potential toxic or cancer-related hazards. Solutions containing formamide in deionized water were deposited directly into the stomachs of male and female rats and mice. Groups of 50 animals received 20, 40, or 80 milligrams of formamide per kilogram body weight 5 days per week for 2 years; groups of animals receiving water alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The only effects observed in male and female rats were lower body weight in animals receiving the highest dose of formamide and a slight increase in bone marrow hyperplasia in male rats. The study concludes that exposure to formamide did not cause cancer in male or female rats, but it did produce hemangiosarcomas in the liver of male mice and may have been related to an increase in liver tumors in female mice. Increased incidence of bone marrow hyperplasia in male rats and testicular mineralization in male mice were also associated with formamide exposure. Illus.