Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study)
Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study)

Author: D. A. Casciano

Publisher: DIANE Publishing

Published: 2008-10

Total Pages: 242

ISBN-13: 1437900739

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Genistein is an isoflavone that occurs in soy products incl. soy-based infant formulas. It is known as ¿environmental estrogens¿ which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. Studies were conducted on 3 such chemicals to see if exposure to such chemicals could have any effect on animals¿ reproductive systems or development of cancers. Rats were exposed to genistein for part or all of the study period and examined at the end of 2 years. Exposure to Genistein for 2 years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to Genistein for shorter durations was also assoc. with increased rates of pituitary gland and mammary gland tumors. Ill.

Nutraceuticals
Nutraceuticals

Author: Ramesh C Gupta

Publisher: Academic Press

Published: 2021-01-27

Total Pages: 1397

ISBN-13: 0128212462

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Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that is currently known about nutraceuticals and their potential toxic effects. The book introduces readers to nutraceuticals, herbal medicines, Ayurvedic medicines, prebiotics, probiotics, adaptogens, and their uses and specific applications. This essential reference discusses the mechanism of action for the judicious use of these nutraceuticals and the best tools for their evaluation before detailing the safety and toxicity of nutraceuticals and interactions with other therapeutic drugs. Finally, and crucially, regulatory aspects from around the world are covered. Completely revised and updated, this updated edition provides toxicologists, pharmacologists, pharmaceutical scientists, and those interested in medicinal plants and natural products with a comprehensive overview of the most effective tools upon which to evaluate the safety and toxicity of nutraceuticals, prebiotics, probiotics and alternative medicines. - Presents a completely revised and updated resource on the impact of nutraceuticals and various disease states such as diabetes and ophthalmic and dermal diseases - Grants an overview of the current state-of-the-science of nutraceuticals, their use and applications, and known adverse effects - Provides effective tools to evaluate the potential toxicity of any nutraceutical - Includes details of regulatory issues as written by international experts

Pharmacotherapeutic Botanicals for Cancer Chemoprevention
Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author: Manish Kumar

Publisher: Springer Nature

Published: 2020-07-20

Total Pages: 344

ISBN-13: 9811559996

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The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Inflammation, Oxidative Stress, and Cancer
Inflammation, Oxidative Stress, and Cancer

Author: Ah-Ng Tony Kong

Publisher: CRC Press

Published: 2016-04-19

Total Pages: 631

ISBN-13: 1466503718

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Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and

Challenges in Endocrine Disruptor Toxicology and Risk Assessment
Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Author: Alberto Mantovani

Publisher: Royal Society of Chemistry

Published: 2020-12-08

Total Pages: 539

ISBN-13: 1839160837

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Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Phytomicronutriments
Phytomicronutriments

Author: IFN

Publisher: Lavoisier

Published: 2012-04-20

Total Pages: 410

ISBN-13: 274306417X

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Cet ouvrage répond aux questionnements scientifiques posés sur les effets biologiques des phytomicronutriments (polyphénols, phytostérols, caroténoïdes, glucosinolates…), dans le double contexte de transition nutritionnelle et du vieillissement de la population, et dans le cadre du rôle potentiel de notre alimentation dans la gestion de notre santé. Fruit d'un travail collectif initié par l'Institut français pour la nutrition (IFN) Les phytomicronutriments présente : - une classification des différentes familles de phytomicronutriments, - les principaux facteurs de variation impactant sur les quantités ingérées et sur leur biodisponibilité, car les effets santé des phytomicronutriments dépendent de leurs niveaux de consommation et de leur biodisponibilité, - leur fonctionnalité puis leur impact dans des populations spécifiques (femmes ménopausées, sportifs et personnes âgées), - les bénéfices/risques de quelques classes de molécules, les plus étudiées : phyto-oestrogènes, phytostérols et caroténoïdes, - une illustration de la composition en phytomicronutriments dans des menus types et la possibilité de les repérer dans les aliments sur la base de la couleur de ces derniers. Cet ouvrage s'adresse aux scientifiques, aux professionnels de l'industrie alimentaire, aux professionnels de la santé, aux enseignants et aux étudiants dans le domaine de la nutrition et de la santé.