Targeting Development

Targeting Development

Author: Richard Black

Publisher: Routledge

Published: 2003-11-20

Total Pages: 484

ISBN-13: 1134410794

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The Millennium Development Goals accepted by the UN in 2000 are, along with the targets set by the OECD in 1996 the subject of this expertly written book. Is development achievable in the time frames given? How useful were the goals in the first place? How far have we come in solving the aching problems of the developing world? These questions and


Targeting Development

Targeting Development

Author: Richard Black

Publisher: Routledge

Published: 2003-11-20

Total Pages: 385

ISBN-13: 1134410808

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The Millennium Development Goals accepted by the UN in 2000 are, along with the targets set by the OECD in 1996 the subject of this expertly written book. Is development achievable in the time frames given? How useful were the goals in the first place? How far have we come in solving the aching problems of the developing world? These questions and more and asked and answered. This impressive collection featuring an array of respected contributors and a preface from Mark Malloch Brown of the UNDP, will be required reading among development economists and those interested in development studies more generally. Perhaps more importantly, the lessons learned from this book shall need to be understood and acted upon by policy makers at both national and international levels.


Improving and Accelerating Therapeutic Development for Nervous System Disorders

Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2014-02-06

Total Pages: 107

ISBN-13: 0309292492

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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.


Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Author: Alexandru Mihai Grumezescu

Publisher: William Andrew

Published: 2018-05-21

Total Pages: 838

ISBN-13: 0128136901

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Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. - Shows how the use of nanomaterials can help target a drug to specific tissues and cells - Explores the development of stimuli-responsive drug delivery systems - Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy


Molecular Targeting in Oncology

Molecular Targeting in Oncology

Author: Howard L. Kaufman

Publisher: Springer Science & Business Media

Published: 2007-12-26

Total Pages: 719

ISBN-13: 1597453374

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This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.


Development of the Nervous System

Development of the Nervous System

Author: Dan H. Sanes

Publisher: Elsevier

Published: 2005-11-02

Total Pages: 388

ISBN-13: 0080472494

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Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the First Edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the First Edition have all been redone and colorized to so that the entire text is in full color. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology. - Updates information including all the new developments made in the field since the first edition - Now in full color throughout, with the original, artist-rendered drawings from the first edition completely redone, revised, colorized, and updated


Disease Control Priorities in Developing Countries

Disease Control Priorities in Developing Countries

Author: Dean T. Jamison

Publisher: World Bank Publications

Published: 2006-04-02

Total Pages: 1449

ISBN-13: 0821361805

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Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.


Posttraumatic Growth

Posttraumatic Growth

Author: Richard G. Tedeschi

Publisher: Routledge

Published: 2018-06-12

Total Pages: 420

ISBN-13: 131552743X

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Posttraumatic Growth reworks and overhauls the seminal 2006 Handbook of Posttraumatic Growth. It provides a wide range of answers to questions concerning knowledge of posttraumatic growth (PTG) theory, its synthesis and contrast with other theories and models, and its applications in diverse settings. The book starts with an overview of the history, components, and outcomes of PTG. Next, chapters review quantitative, qualitative, and cross-cultural research on PTG, including in relation to cognitive function, identity formation, cross-national and gender differences, and similarities and differences between adults and children. The final section shows readers how to facilitate optimal outcomes with PTG at the level of the individual, the group, the community, and society.