Dementia and Normal Aging
Dementia and Normal Aging

Author: Felicia A. Huppert

Publisher: Cambridge University Press

Published: 1994-06-30

Total Pages: 596

ISBN-13: 9780521413930

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Age has been identified as the strongest risk factor for Alzheimer's disease, and is also strongly associated with vascular dementia. With this relationship in mind, this book looks upon the challenge of dementia as establishing its true relationship with normal aging. The traditional disease model of dementia may have obscured important clues about many underlying causes and features of dementia. In this book, experts and pioneers in the fields of aging and dementia make an important contribution to the understanding of dementia by reappraising the latest research in the light of the continuum model. Evidence for and against numerous models of dementia are discussed with particular relevance to the relationship between Alzheimer's and normal aging. Ranging from molecular genetics and fundamental neurobiology to issues of diagnosis and the provision of services, this is a challenging work in its breadth and level of argument, which has far reaching implications for the study of dementia, and indeed of the mind itself. As a review of current thinking and research it will serve as an essential text for clinicians and scientific investigators.

Plaques and Tangles
Plaques and Tangles

Author: Nicola Wilson

Publisher: Faber & Faber

Published: 2015-10-22

Total Pages: 134

ISBN-13: 0571328970

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I do not accept there is anything wrong with me. Days before her wedding Megan discovers she has a 50-50 chance of developing early onset Alzheimer's. Years later she's offered a genetic test. But if she's got the gene does she really want to know? Megan, 21. Megan, 47. Megan, 32. Megan, 27. One woman lurches through time while her young family deal with the consequences. I can't think. But I still feel. And most of the time I feel scared. Scared because it's too soon. I haven't finished yet. Plaques and Tangles by Nicola Wilson premiered at the Royal Court Theatre, London, in October 2015.

Magnesium in the Central Nervous System
Magnesium in the Central Nervous System

Author: Robert Vink

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 354

ISBN-13: 0987073052

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The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Ageing and Dementia
Ageing and Dementia

Author: Kurt Jellinger

Publisher: Springer Science & Business Media

Published: 2002-08-20

Total Pages: 400

ISBN-13: 9783211837979

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Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.

The Problem of Alzheimer's
The Problem of Alzheimer's

Author: Jason Karlawish

Publisher: St. Martin's Press

Published: 2021-02-23

Total Pages: 269

ISBN-13: 1250218748

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A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

Molecular Pathology of Alzheimer's Disease
Molecular Pathology of Alzheimer's Disease

Author: Rudy Castellani

Publisher: Biota Publishing

Published: 2013-10-01

Total Pages: 93

ISBN-13: 1615046399

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Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders
The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders

Author: David F. Cechetto

Publisher: Academic Press

Published: 2016-10-14

Total Pages: 342

ISBN-13: 0128019565

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The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer's Disease, Parkinson's, addiction, and cardiovascular dysregulation. Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value. - Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvement - Presents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentally - Provides expert commentary and a perspective on future trends at the end of each chapter - Addresses translational advances and promising therapeutic options - Includes references to key articles for additional detailed study

Pathobiology of Alzheimer's Disease
Pathobiology of Alzheimer's Disease

Author:

Publisher: Elsevier

Published: 1995-10-17

Total Pages: 273

ISBN-13: 0080538495

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Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.* * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text

The Biology of Human Longevity
The Biology of Human Longevity

Author: Caleb E. Finch

Publisher: Elsevier

Published: 2010-07-28

Total Pages: 640

ISBN-13: 0080545947

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Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. - Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists - Provides a novel synthesis of existing ideas about the biology of longevity and aging - Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

The Neuropathology of Dementia
The Neuropathology of Dementia

Author: Margaret M. Esiri

Publisher: Cambridge University Press

Published: 2004-07-22

Total Pages: 600

ISBN-13: 9780521819152

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Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia. New material includes: Three entirely new chapters on neuroimaging, molecular diagnostics, and transgenic models. Two chapters on tauopathies under new authorship. A chapter under new authorship on synucleinopathies, which includes multiple system atrophy.