Systemic Fibroinflammatory Disorders
Systemic Fibroinflammatory Disorders

Author: Augusto Vaglio

Publisher: Springer

Published: 2017-01-09

Total Pages: 248

ISBN-13: 331941349X

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This book provides detailed information on the nosology, pathology, pathogenesis, clinical presentation, diagnosis and treatment of fibro-inflammatory disorders, rare diseases that often display systemic organ involvement. Among the conditions considered are IgG4-related disease, sclerosing cholangitis, Hashimoto’s and Riedel’s thyroiditis, retroperitoneal fibrosis/chronic periaortitis, mediastinal fibrosis, Erdheim-Chester disease, gadolinium-induced fibrosis, and sclerosing mesenteritis. This group of entities is still poorly defined and is characterized by the common denominator of chronic inflammatory infiltrate admixed with abundant fibrosis. IgG4-related disease is the prototypical example. Systemic Fibroinflammatory Disorders is the first book to draw together information on these conditions. As these diseases often require an interdisciplinary approach, the book is addressed to specialists of different disciplines, especially internists, rheumatologists, nephrologists, clinical immunologists, and hematologists.

IgG4-Related Sclerosing Cholangitis
IgG4-Related Sclerosing Cholangitis

Author: Terumi Kamisawa

Publisher: Springer

Published: 2018-07-31

Total Pages: 141

ISBN-13: 9811045488

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This book aims to raise awareness of IgG4-related sclerosing cholangitis among practicing physicians and to equip readers with a sound understanding of the principles of diagnosis and treatment. Clinical, serological, and histopathological features are clearly described and imaging appearances on all relevant modalities are illustrated, covering the bile duct and other involved organs. Differential diagnosis from other diseases, including primary sclerosing cholangitis and cholangiocarcinoma, is precisely explained. Information is then presented on all significant current and emerging therapeutic strategies, including steroids, immunosuppressive drugs, and rituximab. Finally, attention is drawn to significant prognostic features. While IgG4-related sclerosing cholangitis is now a widely acknowledged condition, most practitioners are still liable to misdiagnose it owing to a lack of familiarity with its presenting features. This book should help to rectify the situation and will be an asset for all who may encounter the disease in clinical practice.

IgG4-Related Kidney Disease
IgG4-Related Kidney Disease

Author: Takao Saito

Publisher: Springer

Published: 2016-11-09

Total Pages: 298

ISBN-13: 4431556877

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This book offers a detailed review of the pathological and imaging features, diagnosis and treatment of IgG4-Related Kidney Disease (IgG4-RKD). IgG4-related disease (IgG4-RD), which is characterized by an elevated serum IgG4 level and infiltration of systemic organs by IgG4 positive plasma cells, is a newly recognized systemic disease. Diverse renal manifestations including specific tubulointerstitial nephritis, membranous nephropathy, and tumor-like urological diseases extending to the pelvis and urinary tract in IgG4-RD have been reported and are recently attracting attention as IgG4-RKD. In this book, leading researchers in the field present the latest insights into the broad spectrum of IgG4-RKD characteristics. In addition, they provide a detailed explanation of the pathology of IgG4-RKD including comparisons between the kidney and other affected organs, such as the lacrimal, salivary glands and pancreas in the histopathological section. IgG4-Related Kidney Disease will have a major impact on future immunological and nephrological studies and offers a useful resource not only for nephrologists but also general physicians and investigators in related fields.

Diseases of the Brain, Head and Neck, Spine 2020–2023
Diseases of the Brain, Head and Neck, Spine 2020–2023

Author: Juerg Hodler

Publisher: Springer Nature

Published: 2020-02-14

Total Pages: 252

ISBN-13: 303038490X

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This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae
The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

Author: Rainer Straub, MD

Publisher: Academic Press

Published: 2015-04-21

Total Pages: 390

ISBN-13: 9780128033210

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Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting - cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation-related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory Contains color figures and tables that explain the field to newcomers

Histiocytic Disorders
Histiocytic Disorders

Author: Oussama Abla

Publisher: Springer

Published: 2017-11-17

Total Pages: 391

ISBN-13: 3319596322

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This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses. Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Rare and Interesting Cases in Pulmonary Medicine
Rare and Interesting Cases in Pulmonary Medicine

Author: Ali Ataya

Publisher: Academic Press

Published: 2017-02-01

Total Pages: 246

ISBN-13: 0128097671

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Rare and Interesting Cases in Pulmonary Medicine provides a look into the uncommon diseases encountered in the field of pulmonary medicine. Using a case-based approach, the book provides clinical scenarios that include relevant accompanying radiology and pathology. Also included are frequently asked questions for each area, as well as a diagnosis and summary, presenting the reader with the most high yield information on each topic. Appropriate for medical students, residents, fellows, and physicians interested in pulmonary medicine, the case-based approach to each topic allows accessibility to the uncommon diseases of the field while also highlighting high yield and important points. Provides case-based approaches to the uncommon diseases of pulmonary medicine, including supporting radiology and pathology Includes uncommon case studies, providing relevant references for further reading and research opportunities Presents related topics with accompanying clinical pearls for direct application in the field

Cardiovascular Pathology
Cardiovascular Pathology

Author: L. Maximilian Buja

Publisher: Academic Press

Published: 2015-11-11

Total Pages: 833

ISBN-13: 0128004592

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Cardiovascular Pathology, Fourth Edition, provides users with a comprehensive overview that encompasses its examination, cardiac structure, both normal and physiologically altered, and a multitude of abnormalities. This updated edition offers current views on interventions, both medical and surgical, and the pathology related to them. Congenital heart disease and its pathobiology are covered in some depth, as are vasculitis and neoplasias. Each section has been revised to reflect new discoveries in clinical and molecular pathology, with new chapters updated and written with a practical approach, especially with regards to the discussion of pathophysiology. New chapters reflect recent technological advances with cardiac devices, transplants, genetics, and immunology. Each chapter is highly illustrated and covers contemporary aspects of the disease processes, including a section on the role of molecular diagnostics and cytogenetics as specifically related to cardiovascular pathology. Customers buy the Print + Electronic product together! Serves as a contemporary, all-inclusive guide to cardiovascular pathology for clinicians and researchers, as well as clinical residents and fellows of pathology, cardiology, cardiac surgery, and internal medicine Offers new organization of each chapter to enable uniformity for learning and reference: Definition, Epidemiology, Clinical Presentation, Pathogenesis/Genetics, Light and Electron Microscopy/Immunohistochemistry, Differential Diagnosis, Treatment and Potential Complications Features six new chapters and expanded coverage of the normal heart and blood vessels, cardiovascular devices, congenital heart disease, tropical and infectious cardiac disease, and forensic pathology of the cardiovascular system Contains 400+ full color illustrations and an online image collection facilitate research, study, and lecture slide creation

Clinical Oral Medicine and Pathology
Clinical Oral Medicine and Pathology

Author: Jean M. Bruch

Publisher: Springer Science & Business Media

Published: 2009-11-11

Total Pages: 176

ISBN-13: 1603275207

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Clinical Oral Medicine and Pathology, is a clinically relevant and accessible resource for health care professionals that truly bridges the worlds of dentistry and medicine. This handbook of oral medicine and oral pathology serves as a highly readable guide for diagnosis and treatment of commonly encountered oral conditions. The volume is organized by grouping clinical entities under easily recognizable, diagnostically related headings and subheadings and allows the busy clinician to quickly reference and identify a lesion of interest. Concise descriptions of each entity provide background information and treatment recommendations while including specific guidelines on diagnosis, management, and follow-up. The authors of this text both have extensive training in the fields of oral pathology, dentistry, oral surgery and otolaryngology, and provide a comprehensive approach to the practice of oral medicine for all those who are likely to encounter diseases of the oral cavity in their daily practice.