Synthesis of Novel Quorum Sensing Molecules
Author: Lacie Marie Smith
Publisher:
Published: 2005
Total Pages: 28
ISBN-13:
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Author: Lacie Marie Smith
Publisher:
Published: 2005
Total Pages: 28
ISBN-13:
DOWNLOAD EBOOKAuthor: V. Ravishankar Rai
Publisher: CRC Press
Published: 2020-05-04
Total Pages: 407
ISBN-13: 1000051471
DOWNLOAD EBOOKThe book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling
Author: Giuseppina Tommonaro
Publisher: Academic Press
Published: 2019-04-08
Total Pages: 309
ISBN-13: 012814906X
DOWNLOAD EBOOKQuorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology Considers QS as an approach to the discovery of new antibiotics Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications Summarizes key results on QS mechanisms’ molecular basis and fields of application
Author: Marc Andrew Prablek
Publisher:
Published: 2013
Total Pages: 0
ISBN-13:
DOWNLOAD EBOOKAuthor: Margrith Eileen Mattmann
Publisher:
Published: 2010
Total Pages: 333
ISBN-13:
DOWNLOAD EBOOKAuthor: Pallaval Veera Bramhachari
Publisher: Springer
Published: 2019-01-28
Total Pages: 381
ISBN-13: 9811324298
DOWNLOAD EBOOKThis book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.
Author: Vipin Chandra Kalia
Publisher: Springer
Published: 2018-05-30
Total Pages: 473
ISBN-13: 9811090262
DOWNLOAD EBOOKThis book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors. Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.
Author: Vipin Chandra Kalia
Publisher: Springer
Published: 2014-09-29
Total Pages: 383
ISBN-13: 8132219821
DOWNLOAD EBOOKMicrobial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?
Author: Sean Michael Callahan
Publisher:
Published: 1999
Total Pages: 192
ISBN-13:
DOWNLOAD EBOOKIn this study five proteins regulated by quorum sensing are described from the marine bacterium Vibrio fischeri. Each protein is positively regulated by 30C6-HSL and LuxR and negatively regulated at low population density by C8-HSL. Probable LuxR/autoinducer binding sites are found in the promoter regions of the genes encoding each of the proteins. QsrP and RibB are encoded monocistronically, whereas AcfA and QsrV appear to be encoded by a two-gene operon. In competition assays with the parent strain, qsrP and acfA insertion mutants displayed altered colonization phenotypes with the squid symbiotic host. RibB is believed to be an enzyme that catalyzes an initial step of riboflavin synthesis and AcfA is believed to be a pilus subunit protein. The functions of QsrP and QsrV are unknown at this time. Oriented divergently from acfA are open reading frames that code for two putative members of the LysR family of transcriptional regulators. The shared promoter region suggests that transcription of acfA and qsrv may be regulated by one or both of these divergently transcribed proteins. This work defines a quorum-sensing regulon in V. fischeri. A model describing its regulation is presented.
Author: Lindsay Leighton Boone
Publisher:
Published: 2003
Total Pages: 38
ISBN-13:
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