Written in a clear and understandable manner, this book provides a comprehensive, yet non-mathematical, treatment of the topic, covering the basic principles of symmetry and the important spectroscopic techniques used to probe molecular structure. The chapters are extensively illustrated and deal with such topics as symmetry elements, operations and descriptors, symmetry guidelines, high-fidelity pseudosymmetry, crystallographic symmetry, molecular gears, and experimental techniques, including X-ray crystallography and NMR spectroscopy. As an additional feature, 3D animations of most of the structures and molecules covered are available online at wiley.com. As a result, chemists learn how to understand and predict molecular structures and reactivity. Authored by a renowned expert with numerous publications and an excellent track record in research and teaching, this is a useful source for graduate students and researchers working in the field of organic synthesis, physical chemistry, biochemistry, and crystallography, while equally serving as supplementary reading for courses on stereochemistry, organic synthesis, or crystallography.
An overview of the importance and consequences of asymmetry from molecules to the macroscopic world As scientists have become more capable of probing the structure of three-dimensional objects at the molecular level, the need to understand the concept and the consequences of mirror-image asymmetry—chirality—has increased enormously. Written at an introductory level, Mirror-Image Asymmetry provides an overview of the importance and effects of asymmetry from the atomic and molecular world of physics and chemistry to the organisms and structures that we see and use in our everyday life. The reader will develop a broad appreciation of three-dimensional asymmetry from the microscopic molecular world to the macroscopic world of handedness, automobile driving, windmills, sports, and similar phenomena. The book features: An introduction to basic definitions and the nomenclature of asymmetric and dissymmetric molecules Up-to-date examples of the importance and consequences of asymmetry in modern drug applications, current theories of the origin of asymmetry in nature, and examples of molecular asymmetry in smell, taste, and insect communication Many illustrations, chemical structures, and photographs that enable the reader to connect the actual asymmetrical structures to the different phenomena that depend on structural asymmetry In the 150 years since Louis Pasteur discovered asymmetry in molecular structures, scientists have made great progress in understanding how interactions between chiral molecules influence biochemical processes. This knowledge is leading to very sophisticated asymmetric synthetic techniques that have greatly benefitted many research groups especially those in the pharmaceutical industry. This guide to the role of molecular and macroscopic chirality will inspire students and scientists in chemistry, biology, physics, and drug discovery.
This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.
This book provides an interdisciplinary review of one of the great unsolved mysteries that has fascinated scientists for over 150 years: the origin of chirality in biomolecules. It was Pasteur who first initiated the search for a deterministic theory to explain the 'handedness' of biomolecules. His theory, that a 'dissimetric' force was involved, was correct in essence but he never saw the fruits of his labour. Current thinking tells us that asymmetry in the universe has its origins in the forces that unfolded after the Big Bang and, more specifically, the weak force. Being 'left handed', the weak force imprinted its signature on the evolving Universe. However, at the molecular level, the weak force does not provide a straightforward explanation of biomolecular homochirality. In fact, it is yet to be proved beyond doubt that a causal link exists at all. Many alternative theories have been put forward, some of them resting on solid ground, but all lacking definitive experimental evidence to back them up. Some postulate that the handedness of molecules in the biosphere arose by chance but this is hard to test. Others rely on discovering life on similar planets and making comparisons with Earth. Alternative theories have emerged from a range of backgrounds including geology, biology, chemistry, physics and astronomy. Current advances in fields as diverse as space exploration, prebiotic chemistry and high-energy physics may help to provide an answer. Important pieces of information will come from observations at the two frontiers of science: outer space and the subatomic world. Observation of distant planets, galaxies, and even actual sampling of celestial objects from beyond the solar system are projects currently underway. At the other end of the spectrum, there are experiments that study the elemental properties of matter, such as symmetry, and interactions with the fundamental forces. All these efforts will render their fruits soon. This volume unifies all the theories of the origin of biomolecular homochirality together in one source. The various chapters focus on chance mechanisms, physical forces such as the 'weakinteraction', fluid dynamics, amplification of chirality, the organic contents of meteorites and comets and, finally, the physical view of an intrinsically asymmetric universe. This complete, interdisciplinary review of an intriguing subject condenses a large and disparate range of contributions from journals in almost every scientific field. The various theories have been organized, interrelated and explained in a unified way. One of the book's strengths is its extensive use of graphic material to aid understanding the many subjects covered. It is fundamental, comprehensive and structured to be accessible for educational purposes.
Almost all theories of fundamental interactions are nowadays based on the gauge concept. Starting with the historical example of quantum electrodynamics, we have been led to the successful unified gauge theory of weak and electromagnetic interactions, and finally to a non abelian gauge theory of strong interactions with the notion of permanently confined quarks. The. early theoretical work on gauge theories was devoted to proofs of renormalizability, investigation of short distance behaviour, the discovery of asymptotic freedom, etc . . , aspects which were accessible to tools extrapolated from renormalised perturbation theory. The second phase of the subject is concerned with the problem of quark confinement which necessitates a non-perturbative understanding of gauge theories. This phase has so far been marked by the introduc tion of ideas from geometry, topology and statistical mechanics in particular the theory of phase transitions. The 1979 Cargese Institute on "Recent Developments on Gauge Theories" was devoted to a thorough discussion of these non-perturbative, global aspects of non-abelian gauge theories. In the lectures and seminars reproduced in this volume the reader wilf find detailed reports on most of the important developments of recent times on non perturbative gauge fields by some of the leading experts and innovators in this field. Aside from lectures on gauge fields proper, there were lectures on gauge field concepts in condensed matter physics and lectures by mathematicians on global aspects of the calculus of variations, its relation to geometry and topology, and related topics.
A comprehensive discussion of group theory in the context of molecular and crystal symmetry, this book covers both point-group and space-group symmetries. - Provides a comprehensive discussion of group theory in the context of molecular and crystal symmetry - Covers both point-group and space-group symmetries - Includes tutorial solutions
Ch. 1. Ingredients of the standard model. 1.1. Strong interaction - QCD. 1.2. Electroweak theory. 1.3. CKM mass matrix -- ch. 2. Symmetries and wave functions. 2.1. Why is symmetry important? 2.2. Symmetry current. 2.3. SU(2). 2.4. SU(3). 2.5. Multi-particle states. 2.6. Product-states. 2.7. Quark model wave functions -- ch. 3. Chiral symmetry. 3.1. Lorentz group and chiral fermions. 3.2. Chiral group. 3.3. Spontaneous breaking of chiral symmetry -- ch. 4. The sigma model. 4.1. Linear sigma model. 4.2. Non-linear sigma model. 4.3. Fermion field -- ch. 5. Chiral bag model. 5.1. The MIT bag model. 5.2. The little bag model. 5.3. The Skyrme model. 5.4. The chiral bag model. 5.5. Chiral casimir effects. 5.6. The edgehog solution -- ch. 6. Nucleon properties. 6.1. Semiclassical method. 6.2. Isospin rotation of the hedgehog solution. 6.3. Axial properties. 6.4. Non-rigid quantization of the skyrmion. 6.5. Electromagnetic properties. 6.6. Chiral bag with vector mesons -- ch. 7. Large-Nc baryons. 7.1. Introduction. 7.2. General counting rules. 7.3. Counting rules for solitons. 7.4. Large-Nc algebra for baryons. 7.5. Finite Nc. 7.6. Other representations and gA -- ch. 8. Excited baryons. 8.1. Systematics in baryon masses. 8.2. Quarks in a deformed oscillator potential. 8.3. Electromagnetic transitions.
The authors, world-renowned scientists, have already produced a dozen books on symmetry for professionals as well as lay persons, for grownups as well as children, in English, Russian, German, Hungarian, and Swedish languages. They provide this attractive account of symmetry in few words and many oOe1/4OCO as many as 650 oOe1/4OCO images in full color from the most diverse corners of our globe. An encounter with this book will open up a whole new experience for the reader, who will never look at the world with the same eyes as before."
The elucidation of reaction mechanisms generally requires the carefully designed control of molecular symmetry to distinguish between the many possible reaction pathways. Making and Breaking Symmetry in Chemistry emphasises the crucial role played by symmetry in modern synthetic chemistry. After discussion of a number of famous classical experiments, the advances brought about by the introduction of new techniques, in particular NMR spectroscopy, are exemplified in numerous cases taken from the recent literature. Experimental verification of many of the predictions made in Woodward and Hoffmann's explication of the Conservation of Orbital Symmetry are described. Applications that involve the breaking of molecular symmetry to resolve these and other mechanistic problems in organic, inorganic and organometallic chemistry are presented in the first sections of the book, together with many examples of the detection of hitherto hidden rearrangement processes. Subsequently, under the aegis of making molecular symmetry, examples of the preparation of highly symmetrical molecules found in the organic, organometallic or inorganic domains are discussed. These include Platonic hydrocarbons or boranes, tetrahedranes, cubanes, prismanes, dodecahedrane, fullerene fragments such as corannulene, sumanene or semibuckminsterfullerene, and other systems of unusual geometries or bonding characteristics (Möbius strips, molecular brakes and gears, Chauvin's carbomers, Fitjer's rotanes, persubstituted rings, metal-metal multiple bonds, etc.). The text also contains vignettes of many of the scientists who made these major advances, as well as short sections that briefly summarise key features of important topics that underpin the more descriptive material. These include some aspects of chirality, NMR spectroscopy, and the use of isotopic substitution to break molecular symmetry. A brief appendix on point group symmetry and nomenclature is also helpfully provided.
The applications of topological techniques for understanding molecular structures have become increasingly important over the past thirty years. In this topology text, the reader will learn about knot theory, 3-dimensional manifolds, and the topology of embedded graphs, while learning the role these play in understanding molecular structures. Most of the results that are described in the text are motivated by questions asked by chemists or molecular biologists, though the results themselves often go beyond answering the original question asked. There is no specific mathematical or chemical prerequisite; all the relevant background is provided. The text is enhanced by nearly 200 illustrations and more than 100 exercises. Reading this fascinating book, undergraduate mathematics students can escape the world of pure abstract theory and enter that of real molecules, while chemists and biologists will find simple, clear but rigorous definitions of mathematical concepts they handle intuitively in their work.
