Comparative Biochemistry of Parasites
Comparative Biochemistry of Parasites

Author: H Van den Bossche

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 533

ISBN-13: 0323146880

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Comparative Biochemistry of Parasites contains the proceedings of an international symposium organized by the Janssen Research Foundation and held at Janssen Pharmaceutica in Belgium on September 1-3, 1971. The symposium reviewed progress in the understanding of the physiology and biochemistry of parasites such as protozoa and helminths. Organized into 34 chapters, this volume begins with an overview of early research on parasite biochemistry before turning to a discussion of antischistosomal drugs and their biochemical effects on parasites. The reader is then introduced to the biochemistry of carbohydrates in nematodes and cestodes; neurotransmitters in trematodes; pharmacological aspects and biochemical effects of tetramisole; the mechanism of action of berenil (Diminazene) and related compounds; and dihydrofolate reductases in parasitic protozoa and helminths. Other chapters focus on the loss of fatty acid biosynthesis in flatworms, the cytochrome system in Kinetoplastidae, oxidative phosphorylation in Moniezia mitochondria, and the role of non-heme iron in cestode respiration. Scientists, particularly physiologists and biochemists, will find this book an invaluable source of information on parasite physiology and biochemistry.

Genetic Recombination
Genetic Recombination

Author: Alan S. Waldman

Publisher: Springer Science & Business Media

Published: 2008-02-03

Total Pages: 259

ISBN-13: 1592597610

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Genetic recombination, in the broadest sense, can be defined as any process in which DNA sequences interact and undergo a transfer of information, producing new “recombinant” sequences that contain information from each of the original molecules. All organisms have the ability to carry out recombination, and this striking universality speaks to the essential role recombination plays in a variety of biological processes fundamentally important to the maintenance of life. Such processes include DNA repair, regulation of gene expression, disease etiology, meiotic chromosome segregation, and evolution. One important aspect of recombination is that it typically occurs only between sequences that display a high degree of sequence identity. The stringent requirement for homology helps to ensure that, under normal circumstances, a cell is protected from deleterious rearrangements since a swap of genetic information between two nearly identical sequences is not expected to dramatically alter a genome. Recombination between dissimilar sequences, which does happen on occasion, may have such harmful consequences as chromosomal translocations, deletions, or inversions. For many organisms, it is also important that recombination rates are not too high lest the genome become destabilized. Curiously, certain organisms, such as the trypanosome parasite, actually use a high rate of recombination at a particular locus in order to switch antigen expression continually and evade the host immune system effectively.

Advances in Parasitology
Advances in Parasitology

Author:

Publisher: Elsevier

Published: 2003-09-25

Total Pages: 220

ISBN-13: 0080471943

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First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Now edited by J.R. Baker, R. Muller, and D. Rollinson, and supported by an international editorial board, Advances in Parasitology includes medical studies on parasites of major influence, such as typanosomiasis and scabies, and reviews of more traditional areas, such as zoology, taxonomy, and life history. Eclectic volumes are supplemented by thematic volumes on such topics as Remote Sensing and Geographical Information Systems in Epidemiology.* Second in the ISI Parasitology List in 2001* Enjoys an Impact Factor of 4.097* Series encompasses over 35 years of parasitology coverage

Progress in Polyamine Research
Progress in Polyamine Research

Author: V. Zappia

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 755

ISBN-13: 1468456377

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This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.

Microfluidics for Single-Cell Analysis
Microfluidics for Single-Cell Analysis

Author: Jin-Ming Lin

Publisher: Springer Nature

Published: 2019-08-28

Total Pages: 263

ISBN-13: 9813297298

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This book summarizes the various microfluidic-based approaches for single-cell capture, isolation, manipulation, culture and observation, lysis, and analysis. Single-cell analysis reveals the heterogeneities in morphology, functions, composition, and genetic performance of seemingly identical cells, and advances in single-cell analysis can overcome the difficulties arising due to cell heterogeneity in the diagnostics for a targeted model of disease. This book provides a detailed review of the state-of-the-art techniques presenting the pros and cons of each of these methods. It also offers lessons learned and tips from front-line investigators to help researchers overcome bottlenecks in their own studies. Highlighting a number of techniques, such as microfluidic droplet techniques, combined microfluidics-mass-spectrometry systems, and nanochannel sampling, it describes in detail a new microfluidic chip-based live single-cell extractor (LSCE) developed in the editor’s laboratory, which opens up new avenues to use open microfluidics in single-cell extraction, single-cell mass spectrometric analysis, single-cell adhesion analysis and subcellular operations. Serving as both an elementary introduction and advanced guidebook, this book interests and inspires scholars and students who are currently studying or wish to study microfluidics-based cell analysis methods.

Advances in Insect Physiology
Advances in Insect Physiology

Author:

Publisher: Academic Press

Published: 2009-10-13

Total Pages: 363

ISBN-13: 0080888739

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This latest volume in this series contains articles on the physiology of human and animal disease vectors. The papers in this special issue give rise to key themes for the future and make progress towards answering such questions as:How do insect vectors of disease find their animal hosts?Once a host is located, how do insects deploy their intricate mouthparts and the extraordinary complexities of salivary chemistry to secure a blood meal? - Contributions from the leading researchers in entomology - Discusses the physiological diversity in insects - Includes in-depth reviews with valuable information for a variety of entomology disciplines

The African Trypanosomes
The African Trypanosomes

Author: Samuel J. Black

Publisher: Springer Science & Business Media

Published: 2006-04-11

Total Pages: 185

ISBN-13: 0306468948

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African trypanosomes are tsetse-transmitted protozoa that inhabit the extracellular compartment of host blood. They cause fatal sleeping sickness in people, and Nagana, a wasting and generally fatal disease, in cattle. While trypanosomes are most common to Africa (about 30% of Africa's cattle graze on the fringe of the tsetse habitat), some species have spread beyond its boarders to Asia, the Middle East and South America. The African Trypanosomes, volume one of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.

International Review of Cytology
International Review of Cytology

Author: Kwang W. Jeon

Publisher: Elsevier

Published: 2005-07-25

Total Pages: 366

ISBN-13: 0080457797

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International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address Plastid RNA polymerases, promoters, and transcription regulators in higher plants; Maintenance of Golgi Apparatus Structure in the Face of Continuous Protein Recycling to the ER: Making Ends Meet; Nucleocytoplasmic trafficking in plant cells; Building in vitro models of organs; Mitrochondria-drived organelles in protists and fungi; The flagellum of trypanosomes; and Regulation of growth and differentiation in Dictyostelium.