Studies on Radiation-induced Chimeras
Studies on Radiation-induced Chimeras

Author: L. J. Cole

Publisher:

Published: 1962

Total Pages: 26

ISBN-13:

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The present experiments are concerned with the attempt to prevent or ameliorate the occurrence of secondary disease deaths in irradiated mice bearing foreign bone marrow grafts; in addition, certain aspects of graft-to-host tolerance in early radiation chimeras have been investigated. It is concluded that specific graft-to-host tolerance may develop relatively early in radiation chimeras, that it is possible to prevent or eliminate secondary disease in homologous radiation chimeras by suitable preirradiation of the marrow donors, and by injection into the chimeras of specific isoantiserum directed against the marrow donor. (Author).

Late Effects Studies on Radiation-induced Homologous Mouse Chimeras
Late Effects Studies on Radiation-induced Homologous Mouse Chimeras

Author: W. E. Davis

Publisher:

Published: 1962

Total Pages: 34

ISBN-13:

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In studies on lymphoid cell chimerism and homograft tolerance in long-lived homologous radiation chimeras, data were collected on life span, and on leukemia and other lesions. The chimeras were hybrid mice (10 - 12 weeks old) exposed to 880 rad of X radiation and injected with bone marrow cells from C3H donors. Out of 119 mice, 65% were dead by age 32 weeks, with symptoms of second ry disease evident in the great majority. Relatively few deaths occurred between 32 and 75 weeks, and the maximum life span was 105 weeks. Histopathological data were obtained from many of these long-lived chimeras. There was an 80% incidence of glomerulosclerosis of moderate to severe degree, and a 20% incidence of arteriolarsclerosis in t e kidney and spleen. Leukemias were observed in 5 out of 54 homologous chimeras. Also, two leukemias occurred in 13 chimeras (15%) which had been injected with lymphoid cells obtained from other long-lived homologous chimeras. The possibility of a causal relationship between s condary disease and the increased incidence of leukemia is briefly discussed. (Author).

Plant Chimeras
Plant Chimeras

Author: Richard A. E. Tilney-Bassett

Publisher: Cambridge University Press

Published: 1991-10-03

Total Pages: 208

ISBN-13: 9780521427876

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This book, which was originally published in 1986, introduces the reader to the main steps in the analysis of chimeras, explains their structural and developmental basis, and the ways of classifying and manipulating them. The twelve chapters separate types of chimeras according to their origin - by grafting or polyploidy; their structure - sectorial or periclinal; or according to the varied parts of the plant most affected - tubers, leaves, flowers or fruit. Throughout the book care is taken to distinguish between the activity of the growing-point in determining chimera structure, and the role of gene expression in determining appearance. Examples of the experimental uses of chimeras are given and of the valuable role they can play in studying fundamental questions of anatomical development; the disadvantages of chimeras in mutation breeding are discussed too.

Hereditary Effects of Radiation
Hereditary Effects of Radiation

Author: United Nations. Scientific Committee on the Effects of Atomic Radiation

Publisher: The Committee

Published: 2001

Total Pages: 166

ISBN-13:

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The 2001 report completed a comprehensive review of the risks to offspring following parental exposure to radiation. The review included an evaluation of those diseases which have both hereditary and environmental components. The major finding is that the total hereditary risk to the first generation following radiation is less than one tenth of the risk of fatal carcinogenesis following irrradiation. The Committee concluded that a sounder basis now exists for estimating the hereditary risks of radiation exposure. This is due to advances in molecular genetics, and in the evaluation of multifactorial diseases, such as coronary heart disease.

Journal
Journal

Author: National Cancer Institute (U.S.)

Publisher:

Published: 1971

Total Pages: 736

ISBN-13:

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Biotechnologies for Plant Mutation Breeding
Biotechnologies for Plant Mutation Breeding

Author: Joanna Jankowicz-Cieslak

Publisher: Springer

Published: 2016-12-08

Total Pages: 343

ISBN-13: 3319450212

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This book is open access under a CC BY-NC 2.5 license. This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.

Health Risks from Exposure to Low Levels of Ionizing Radiation
Health Risks from Exposure to Low Levels of Ionizing Radiation

Author: Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Publisher: National Academies Press

Published: 2006-03-23

Total Pages: 422

ISBN-13: 0309133343

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This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.