Hormones in Lipoprotein Metabolism
Hormones in Lipoprotein Metabolism

Author: Armin Steinmetz

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 311

ISBN-13: 3642848559

DOWNLOAD EBOOK

An intimate relation between hormones and lipoprotein metabolism has been known for a long time especially from hormone-deficiency or -overproduction syndromes. The mechanisms through which hormones influence lipid metabolism have become a field of major interest in sci ence. The more we learn about cellular hormonal actions the better we understand regulatory processes and phenomena occuring in patients. The present book summarizes data discussed at an International Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism". It was an attempt to pull together knowledge in basic science from the mode of action of hormones all the way to clinical appearance of hor monal disorders involving lipoprotein metabolism. Thus data on molec ular biology, on hormonal regulation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are discussed together with the large field of oral contraceptive use, postmenopausal estrogen sub stitution, lipid disorders in diabetes mellitus, in thyroid dysfunction, in adrenal insufficiency and in glucocorticoid application. We are aware of the fact that such an overview cannot be complete but should serve as a collection of data and ideas for those interested in hormonal regulation of lipid metabolism. We thank all authors for taking an extra effort in writing up their presentations and thus making this edition possible. We also thank Bristol-Myers-Squibb for generous support of the meeting and of the final publication. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A.

Hormonal Regulation of Cholesterol Homeostasis
Hormonal Regulation of Cholesterol Homeostasis

Author: Zhuo Mao

Publisher:

Published: 2018

Total Pages:

ISBN-13:

DOWNLOAD EBOOK

Cholesterol homeostasis is tightly regulated by a group of endocrine hormones under physiological conditions. Hormonal dysregulation is often associated with disturbed cholesterol homeostasis, resulting in many clinical disorders including atherosclerosis, fatty liver and metabolic syndrome. Circulating hormones regulate cholesterol metabolism by altering levels of relative genes either through their interactions with nuclear receptors or by interfering with bile acid signaling pathways. A better understanding of hormonal regulation of cholesterol metabolism would improve our likelihood of identifying effective and selective targets for the intervention of disturbed cholesterol. In this review, we discuss selected hormones critical for the cholesterol balance, including thyroid hormone, sex hormones, growth hormone, glucagon and irisin. We focus our discussion on the most recent advance in clinical epidemiology, animal mechanistic studies and the clinical application.

The Biology of Cholesterol and Related Steroids
The Biology of Cholesterol and Related Steroids

Author: N. B. Myant

Publisher: Butterworth-Heinemann

Published: 2014-04-24

Total Pages: 925

ISBN-13: 148328123X

DOWNLOAD EBOOK

The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of cholesterol metabolism and sterols in biological membranes. The book also reviews cholesterol synthesis in animal tissues, sterol metabolism in isolated cells, and epidemiology of the plasma cholesterol. Discussions focus on selection of statistical populations, genetic influences, regulation of sterol synthesis, general aspects of sterol metabolism, and removal of cell cholesterol in vivo. The publication is a dependable source of data for biochemists and readers interested in the biology of cholesterol and steroids.

Hormones and Atherosclerosis
Hormones and Atherosclerosis

Author: Gregory Pincus

Publisher: Academic Press

Published: 2013-10-22

Total Pages: 501

ISBN-13: 1483270645

DOWNLOAD EBOOK

Hormones and Atherosclerosis covers the proceedings of the conference held in Brighton, Utah on March 11-14, 1958. The book focuses on the role of hormones in atherosclerosis, as well as cholesterol metabolism and biosynthesis, lipogenesis, and lipid transport. The selection first discusses the biosynthesis of cholesterol and aspects of the biosynthesis of cholesterol from mevalonic acid. Discussions focus on components of liver homogenates and coenzymes required for squalene and sterol synthesis from mevalonic acid and preservation of enzymes and microsomes. The text also ponders on the formation and metabolism of bile acids under different conditions and thyroid function, thyroxine analogs, and cholesterol metabolism in rats and rabbits. The book elaborates on the comparison of the participations of fibroblasts and reticuloendothelial cells in the synthesis and metabolism of cortisol and cholesterol and control of aortal lipid metabolism and lipid movement by hormones and vitamins. The manuscript also examines the influence of estrogens on lipids and atherosclerosis in experimental animals and the effect of adrenals, pituitary, liver, and mucopolysaccharides on blood lipids. The selection is a dependable reference for readers interested in the relationship of hormones and atherosclerosis.

Regulation of Fatty Acid and Glycerolipid Metabolism
Regulation of Fatty Acid and Glycerolipid Metabolism

Author: Raymond Dils

Publisher: Elsevier

Published: 2014-05-18

Total Pages: 129

ISBN-13: 1483148769

DOWNLOAD EBOOK

Regulation of Fatty Acid and Glycerolipid Metabolism is a compilation of papers presented during the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. The book deals with the regulation of enzyme activity and the turnover that results from fatty acid metabolism, lipid metabolism in membranes, and disturbed fatty acid metabolism. One study presented in the book shows that cellular fatty acid synthetase levels are significantly decreased by different medium and long chain fatty acids in Candida lypolytica, a kind of yeast. The book also examines the serious incidence of increase in the rate of conversion of glucose to fatty acids when white adipose tissues from rats are exposed to insulin. The selection addresses this increase as an important example of acute hormonal regulation of fatty acid synthesis in mammalian tissues. The text also describes the enzyme adaptation to nutritional and hormonal changes and the role of lipids in membrane fusion. The book presents other studies regarding the incidence of vascular, dietary, and congenital factors on fatty acid metabolism in adipose tissue and liver that are conducted in rats. Another study suggests that hyperinsulinemia is a key factor in the development of the obesity syndrome. Microbiologists, microchemists, and laboratory researchers and scientists dealing with fat metabolism will appreciate this book.