Structure-function Studies on the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
Author: Michael Rostam Bavand
Publisher:
Published: 1993
Total Pages: 328
ISBN-13:
DOWNLOAD EBOOKRead and Download eBook Full
Author: Michael Rostam Bavand
Publisher:
Published: 1993
Total Pages: 328
ISBN-13:
DOWNLOAD EBOOKAuthor: Yvonne Kew
Publisher:
Published: 1997
Total Pages: 304
ISBN-13:
DOWNLOAD EBOOKAuthor: Stuart LeGrice
Publisher: Springer Science & Business Media
Published: 2013-07-23
Total Pages: 358
ISBN-13: 1461472911
DOWNLOAD EBOOKThe Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanisms involved in HIV variability and the development of drug resistance. We hope that these contributions will stimulate interest, and encourage research aimed at the development of novel RT inhibitors. The lack of bona fide RNase H inhibitors with potent antiviral activity provides an example for challenges and opportunities in the field.
Author: Nick Mario Cirino
Publisher:
Published: 1995
Total Pages: 350
ISBN-13:
DOWNLOAD EBOOKAuthor: Justin Cole
Publisher:
Published: 1996
Total Pages: 138
ISBN-13:
DOWNLOAD EBOOKAuthor: Seddon Y. Thomas
Publisher:
Published: 1996
Total Pages: 174
ISBN-13:
DOWNLOAD EBOOKAuthor: Bryan Cullen
Publisher: Oxford University Press
Published: 1993
Total Pages: 220
ISBN-13: 9780199633821
DOWNLOAD EBOOKThe first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author: Emilio Emini
Publisher: Princeton University Press
Published: 2021-04-13
Total Pages: 546
ISBN-13: 0691228833
DOWNLOAD EBOOKThe past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent. These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients. Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Götte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.
Author: Wei Hong Zhang
Publisher:
Published: 1996
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Sabine C. Piller
Publisher:
Published: 1998
Total Pages: 498
ISBN-13:
DOWNLOAD EBOOK