Structural Interfaces and Attachments in Biology
Structural Interfaces and Attachments in Biology

Author: Stavros Thomopoulos

Publisher: Springer Science & Business Media

Published: 2012-10-05

Total Pages: 385

ISBN-13: 1461433177

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Attachment of dissimilar materials in engineering and surgical practice is a perennial challenge. Bimaterial attachment sites are common locations for injury, repeated injury, and mechanical failure. Nature presents several highly effective solutions to the challenge of bimaterial attachment that differ from those found in engineering practice. Structural Interfaces and Attachments in Biology describes the attachment of dissimilar materials from multiple perspectives. The text will simultaneously elucidate natural bimaterial attachments and outline engineering principles underlying successful attachments to the communities of tissue engineers and surgeons. Included an in-depth analysis of the biology of attachments in the body and mechanisms by which robust attachments are formed, a review of current concepts of attaching dissimilar materials in surgical practice and a discussion of bioengineering approaches that are currently being developed.

Proceedings of the American Society for Composites 2014-Twenty-ninth Technical Conference on Composite Materials
Proceedings of the American Society for Composites 2014-Twenty-ninth Technical Conference on Composite Materials

Author: Hyonny Kim

Publisher: DEStech Publications, Inc

Published: 2014-09-17

Total Pages: 3583

ISBN-13: 1605951242

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New and not previously published U.S. and international research on composite and nanocomposite materialsFocus on health monitoring/diagnosis, multifunctionality, self-healing, crashworthiness, integrated computational materials engineering (ICME), and moreApplications to aircraft, armor, bridges, ships, and civil structures This fully searchable CD-ROM contains 270 original research papers on all phases of composite materials, presented by specialists from universities, NASA and private corporations such as Boeing. The document is divided into the following sections: Aviation Safety and Aircraft Structures; Armor and Protection; Multifunctional Composites; Effects of Defects; Out of Autoclave Processing; Sustainable Processing; Design and Manufacturing; Stability and Postbuckling; Crashworthiness; Impact and Dynamic Response; Natural, Biobased and Green; Integrated Computational Materials Engineering (ICME); Structural Optimization; Uncertainty Quantification; NDE and SHM Monitoring; Progressive Damage Modeling; Molecular Modeling; Marine Composites; Simulation Tools; Interlaminar Properties; Civil Structures; Textiles. The CD-ROM displays figures and illustrations in articles in full color along with a title screen and main menu screen. Each user can link to all papers from the Table of Contents and Author Index and also link to papers and front matter by using the global bookmarks which allow navigation of the entire CD-ROM from every article. Search features on the CD-ROM can be by full text including all key words, article title, author name, and session title. The CD-ROM has Autorun feature for Windows 2000 or higher products and can also be used with Macintosh computers. The CD includes the program for Adobe Acrobat Reader with Search 11.0. One year of technical support is included with your purchase of this product.

Advanced Materials Modelling for Structures
Advanced Materials Modelling for Structures

Author: Holm Altenbach

Publisher: Springer Science & Business Media

Published: 2013-02-05

Total Pages: 365

ISBN-13: 3642351670

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This volume presents the major outcome of the IUTAM symposium on “Advanced Materials Modeling for Structures”. It discusses advances in high temperature materials research, and also to provides a discussion the new horizon of this fundamental field of applied mechanics. The topics cover a large domain of research but place a particular emphasis on multiscale approaches at several length scales applied to non linear and heterogeneous materials. Discussions of new approaches are emphasised from various related disciplines, including metal physics, micromechanics, mathematical and computational mechanics.

Advances in Protein Molecular and Structural Biology Methods
Advances in Protein Molecular and Structural Biology Methods

Author: Timir Tripathi

Publisher: Academic Press

Published: 2022-01-14

Total Pages: 716

ISBN-13: 0323902650

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Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. - Presents a thorough overview of the latest and emerging methods and technologies for protein study - Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy - Includes computational and machine learning methods - Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins

Bioinformatics Challenges at the Interface of Biology and Computer Science
Bioinformatics Challenges at the Interface of Biology and Computer Science

Author: Teresa K. Attwood

Publisher: John Wiley & Sons

Published: 2016-07-27

Total Pages: 424

ISBN-13: 1119243440

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This innovative book provides a completely fresh exploration of bioinformatics, investigating its complex interrelationship with biology and computer science. It approaches bioinformatics from a unique perspective, highlighting interdisciplinary gaps that often trap the unwary. The book considers how the need for biological databases drove the evolution of bioinformatics; it reviews bioinformatics basics (including database formats, data-types and current analysis methods), and examines key topics in computer science (including data-structures, identifiers and algorithms), reflecting on their use and abuse in bioinformatics. Bringing these disciplines together, this book is an essential read for those who wish to better understand the challenges for bioinformatics at the interface of biology and computer science, and how to bridge the gaps. It will be an invaluable resource for advanced undergraduate and postgraduate students, and for lecturers, researchers and professionals with an interest in this fascinating, fast-moving discipline and the knotty problems that surround it.

Chemical Probes in Biology Science at the Interface of Chemistry, Biology and Medicine
Chemical Probes in Biology Science at the Interface of Chemistry, Biology and Medicine

Author: Manfred P. Schneider

Publisher: Springer Science & Business Media

Published: 2003-11-30

Total Pages: 424

ISBN-13: 9781402017704

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The field of Bio-organic Chemistry or Chemical Biology, as it it also called, constitutes a highly interdisciplinary branch of chemistry, beyond the traditional pathways in which chemists and biologists have been working in the past. The topics covered in this book include inter alia: anticancer agents, antioxidants, chemotaxis, carbohydrates, DNA detection and delivery, enzyme structure, enzyme assisted syntheses, fluorescent probes, gene therapy, genomics, inositol phospholipids, inositol phosphates, multivalent ligands, organic syntheses, oxidative stress, photoaffinity labeling techniques, natural products - syntheses and biological activities, phospholipases, proteomics, receptors such as tyrosine kinases, signal transduction phenomena, x-ray crystallography and many more. The book represents an excellent survey of the current stete of the art in an exciting area of interdisciplinary science and supplies an incentive for increased cooperation in Science at the Interface of Chemistry, Biology and Medicine.

Catalyzing Inquiry at the Interface of Computing and Biology
Catalyzing Inquiry at the Interface of Computing and Biology

Author: National Research Council

Publisher: National Academies Press

Published: 2006-01-01

Total Pages: 469

ISBN-13: 030909612X

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Advances in computer science and technology and in biology over the last several years have opened up the possibility for computing to help answer fundamental questions in biology and for biology to help with new approaches to computing. Making the most of the research opportunities at the interface of computing and biology requires the active participation of people from both fields. While past attempts have been made in this direction, circumstances today appear to be much more favorable for progress. To help take advantage of these opportunities, this study was requested of the NRC by the National Science Foundation, the Department of Defense, the National Institutes of Health, and the Department of Energy. The report provides the basis for establishing cross-disciplinary collaboration between biology and computing including an analysis of potential impediments and strategies for overcoming them. The report also presents a wealth of examples that should encourage students in the biological sciences to look for ways to enable them to be more effective users of computing in their studies.

Structural Biology in Drug Discovery
Structural Biology in Drug Discovery

Author: Jean-Paul Renaud

Publisher: John Wiley & Sons

Published: 2020-01-09

Total Pages: 1437

ISBN-13: 1118900502

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With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

The Biology - Chemistry Interface
The Biology - Chemistry Interface

Author: Raymond Cooper

Publisher: CRC Press

Published: 1999-07-22

Total Pages: 508

ISBN-13: 0824746775

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A tribute to the pioneering scientific work of Professor Koji Nakanishi, whose studies of natural products have effaced some of the conventional boundaries between biology and chemistry. It discusses an array of chromatographic separation methods and determination of structures on a microscale, analyzes bioassay-directed fractionation and other means of isolating biologically active compounds from plants and other sources, covers vital enzymes isolated from marine organisms such as algae, and more.

Structural Genomics and High Throughput Structural Biology
Structural Genomics and High Throughput Structural Biology

Author: Michael Sundstrom

Publisher: CRC Press

Published: 2005-08-23

Total Pages: 304

ISBN-13: 0849361435

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Researchers in structural genomics continue to search for biochemical and cellular functions of proteins as well as the ways in which proteins assemble into functional pathways and networks using either experimental or computational approaches. Based on the experience of leading international experts, Structural Genomics and High Throughput Stru