Nitric Oxide in the Kidney
Nitric Oxide in the Kidney

Author: Jennifer M. Sasser

Publisher: Biota Publishing

Published: 2015-05-01

Total Pages: 58

ISBN-13: 1615046674

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Nitric oxide (NO) is a key regulator of various cellular signaling pathways throughout the body and plays an important role in renal function under normal physiological and pathophysiological conditions. NO plays a major role in the regulation of renal hemodynamics, tubuloglomerular feedback, sodium transport in the nephron, pressure natriuresis, and renal fibrosis and injury; moreover, a deficiency in NO is characteristic of chronic kidney disease in both human patients and in experimental animal models. The goal of this book is to highlight the actions of NO within the kidney and its effects on the regulation of renal blood flow and tubular transport.

Lipids and the Kidney
Lipids and the Kidney

Author: William F. Keane

Publisher: Karger Medical and Scientific Publishers

Published: 1997-01-01

Total Pages: 248

ISBN-13: 9783805563895

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During the past decade, experimental and clinical studies have suggested that dyslipidemia may be an important risk factor for the progression of renal disease. This volume explores in great detail recent advances in our understanding of the pathogenesis and treatment of this common complication of progressive renal injury. In the experimental investigations presented, emphasis is placed on specific disturbances of lipids that are seen in progressive renal disease including the effects of oxidatively modified lipoproteins and Lp(a) on various functions of the glomerular cells. Clinical studies have identified dyslipidemia as a risk factor for progressive renal disease in diabetes mellitus, various non-diabetic renal diseases, and most recently in patients with progressive renal allograft loss. An emerging interest in the genetics of dyslipidemia has recently arisen and this topic as it specifically relates to progressive renal disease is discussed. The final section of the book offers new insights into the mechanisms of action of antilipemic therapy used in the treatment of dyslipidemia. This volume should be read by all nephrologists caring for patients with progressive renal disease and by physicians interested in the biology of lipids, diabetes and essential hypertension.

Statin-Associated Muscle Symptoms
Statin-Associated Muscle Symptoms

Author: Paul D. Thompson

Publisher: Springer Nature

Published: 2020-01-25

Total Pages: 191

ISBN-13: 3030333043

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This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.

Uremic Toxins
Uremic Toxins

Author: Severin Ringoir

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 292

ISBN-13: 1468454455

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The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.

Advances in Statin Therapy & Beyond in CVD (ASTC)
Advances in Statin Therapy & Beyond in CVD (ASTC)

Author: HK Chopra

Publisher: Jaypee Brothers Medical Publishers

Published: 2022-03-30

Total Pages: 981

ISBN-13: 9354653936

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CVD, or cardiovascular disease, is a general term that describes a disease of the heart or blood vessels. It is one of the most common causes of death. Statins are a group of medicines that can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol of often referred to as ‘bad cholesterol’, and statins reduce its production in the liver. Having a high level of LDL is potentially dangerous as it can lead to hardening and narrowing of the arteries (NHS). Comprising nearly 1000 pages, this book is a comprehensive guide to the latest advances in statin therapy and its clinical application for cardiovascular disease. Divided into 29 sections, the text begins with clinical aspects of CVD, dyslipidemia (the imbalance of lipids such as cholesterol), and the use of statins for treatment. The next sections provide detailed discussion on the use of statins for different types of CVD, including coronary artery disease, hypertension, heart failure, arrhythmia, stroke, and more. The following chapters cover statin use for other systemic diseases such as obesity, kidney disease, diabetes, ocular disorders, skin conditions and many more. The book concludes with an insight into future therapies, with emphasis on PCSK9 inhibitors, a new treatment for lowering cholesterol in the blood.

Nutritional Management of Renal Disease
Nutritional Management of Renal Disease

Author: Joel D. Kopple

Publisher: Academic Press

Published: 2021-10-08

Total Pages: 1041

ISBN-13: 0128185414

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Nutritional Management of Renal Disease, Fourth Edition, offers in-depth reviews of the metabolic and nutritional disorders prevalent in patients with renal disease and serves as an in-depth reference source concerning nutrition and kidney disease. This classic translational reference provides correct diagnosis - and therefore correct treatment - of renal, metabolic, and nutritional disorders. Nephrologists, diebetologists, endocrinologists, dieticians, and nutritionists depend on a strong understanding of the molecular basis for the disease. This fourth edition includes thorough new case reports, offering expert advice on how to use the latest research and clinical findings in counseling patients about dietary and lifestyle options. Readers gain insight into which treatments, medications, and diets to use based on the history, progression, and genetic make-up of a patient. Includes the latest comprehensive KDOQI clinical practice guidelines for the nutritional management of kidney disease from the National Kidney Foundation and the Academy of Nutrition and Dietetics, covering recommendations for each essential nutrient, as well as for some nonessential nutrients Presents a comprehensive, translational look at all aspects of metabolic and nutritional disorders in one reference Provides a common language for nephrologists, nutritionists, endocrinologists, and other interested physicians to assimilate information and discuss the underlying research and translation of best practices for the nutritional management and prevention of renal disease Saves clinicians and researchers time in quickly accessing the very latest details on nutritional practice as opposed to searching through thousands of journal articles

Network Meta-analysis
Network Meta-analysis

Author: Giuseppe Biondi-Zoccai

Publisher: Nova Science Publishers

Published: 2014

Total Pages: 0

ISBN-13: 9781633210011

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Network meta-analyses and mixed treatment comparisons represent the uppermost level in the evidence hierarchy for decision making, in medicine as well as in other scholarly fields. This book covers the main topics which should be mastered to critically read and interpret as well as, if deemed worthwhile, perform and report independently a network meta-analysis and mixed treatment comparison. The text includes dozens of tables and illustrations to guide visually the reader in understanding the basics as well as the more refined details of network meta-analyses.

Chronic Kidney Disease
Chronic Kidney Disease

Author: National Collaborating Centre for Chronic Conditions (Great Britain)

Publisher: Royal College of Physicians

Published: 2008

Total Pages: 238

ISBN-13: 1860163408

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This guideline presents clear criteria for testing of chronic kidney disease, for suspecting progressive CKD and referring people for specialist assessment.