Stages and Pathways of Drug Involvement
Stages and Pathways of Drug Involvement

Author: Denise Bystryn Kandel

Publisher: Cambridge University Press

Published: 2002-03-04

Total Pages: 404

ISBN-13: 9780521789691

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(Publisher-supplied data) This book represents the first systematic discussion of the Gateway Hypothesis, a developmental hypothesis formulated to model how adolescents initiate and progress in the use of various drugs. In the United States, this progression proceeds from the use of tobacco or alcohol to the use of marijuana and other illicit drugs. This volume presents a critical overview of what is currently known about the Gateway Hypothesis. The authors of the chapters explore the hypothesis from various perspectives ranging from developmental social psychology to prevention and intervention science, animal models, neurobiology and analytical methodology. This volume is original and unique in its purview, covering a broad view of the Gateway Hypothesis. The juxtaposition of epidemiological, intervention, animal and neurobiological studies represents a new stage in the evolution of drug research, in which epidemiology and biology inform one another in the understanding of drug abuse.

Pathways of Addiction
Pathways of Addiction

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1996-11-01

Total Pages: 330

ISBN-13: 0309055334

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Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

Improving and Accelerating Therapeutic Development for Nervous System Disorders
Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2014-02-06

Total Pages: 107

ISBN-13: 0309292492

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Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Pathways to Recovery and Desistance
Pathways to Recovery and Desistance

Author: David Best

Publisher: Policy Press

Published: 2019-09-04

Total Pages: 232

ISBN-13: 144734930X

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Available Open Access under CC-BY-NC licence. This is the first book that uses the latest research evidence to build guidance on community-based rehabilitation with the aim of challenging stigma and marginalisation. The case studies discussed, and a strengths-based approach, emphasize the importance of long-term recovery and the role that communities and peers play in the process. Best examines effective methods for community growth, offers sustainable ways of promoting social inclusion and puts forward a new drug strategy and a new reform policy for prisons.

Anxiety and Substance Use Disorders
Anxiety and Substance Use Disorders

Author: Sherry H. Stewart

Publisher: Springer Science & Business Media

Published: 2007-12-03

Total Pages: 280

ISBN-13: 0387742905

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Disorders of anxiety and substance use are, for some reason, rarely treated in an integrated fashion by professionals. This timely volume addresses this glaring omission with dispatches from the frontlines of research and treatment. Thirty-four international experts offer findings, theories, and intervention strategies for this common form of dual disorder, across a range of substances and of anxiety disorders, to give the reader comprehensive knowledge in a practical format.

TIP 35: Enhancing Motivation for Change in Substance Use Disorder Treatment (Updated 2019)
TIP 35: Enhancing Motivation for Change in Substance Use Disorder Treatment (Updated 2019)

Author: U.S. Department of Health and Human Services

Publisher: Lulu.com

Published: 2019-11-19

Total Pages: 208

ISBN-13: 1794755136

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Motivation is key to substance use behavior change. Counselors can support clients' movement toward positive changes in their substance use by identifying and enhancing motivation that already exists. Motivational approaches are based on the principles of person-centered counseling. Counselors' use of empathy, not authority and power, is key to enhancing clients' motivation to change. Clients are experts in their own recovery from SUDs. Counselors should engage them in collaborative partnerships. Ambivalence about change is normal. Resistance to change is an expression of ambivalence about change, not a client trait or characteristic. Confrontational approaches increase client resistance and discord in the counseling relationship. Motivational approaches explore ambivalence in a nonjudgmental and compassionate way.

Facing Addiction in America
Facing Addiction in America

Author: Office of the Surgeon General

Publisher: Createspace Independent Publishing Platform

Published: 2017-08-15

Total Pages: 420

ISBN-13: 9781974580620

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All across the United States, individuals, families, communities, and health care systems are struggling to cope with substance use, misuse, and substance use disorders. Substance misuse and substance use disorders have devastating effects, disrupt the future plans of too many young people, and all too often, end lives prematurely and tragically. Substance misuse is a major public health challenge and a priority for our nation to address. The effects of substance use are cumulative and costly for our society, placing burdens on workplaces, the health care system, families, states, and communities. The Report discusses opportunities to bring substance use disorder treatment and mainstream health care systems into alignment so that they can address a person's overall health, rather than a substance misuse or a physical health condition alone or in isolation. It also provides suggestions and recommendations for action that everyone-individuals, families, community leaders, law enforcement, health care professionals, policymakers, and researchers-can take to prevent substance misuse and reduce its consequences.

Introduction to Basics of Pharmacology and Toxicology
Introduction to Basics of Pharmacology and Toxicology

Author: Gerard Marshall Raj

Publisher: Springer Nature

Published: 2019-11-16

Total Pages: 410

ISBN-13: 9813297794

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This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.