Spherical Individual Cell-Based Models
Author: Axel Krinner
Publisher:
Published: 2010
Total Pages: 0
ISBN-13:
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Spherical Individual Cell-Based Models
Author:
Publisher:
Published: 2007
Total Pages:
ISBN-13:
DOWNLOAD EBOOKOver the last decade a huge amount of experimental data on biological systems has been generated by modern high-throughput methods. Aided by bioinformatics, the '-omics' (genomics, transcriptomics, proteomics, metabolomics and interactomics) have listed, quantif ed and analyzed molecular components and interactions on all levels of cellular regulation. However, a comprehensive framework, that does not only list, but links all those components, is still largely missing. The biology-based but highly interdisciplinary field of systems biology aims at such a holistic understanding of complex biological systems covering the length scales from molecules to whole organisms. Spanning the length scales, it has to integrate the data from very different fields and to bring together scientists from those fields. For linking experiments and theory, hypothesis-driven research is an indispensable concept, formulating a cycle of experiment, modeling, model predictions for new experiments and, fi nally, their experimental validation as the start of the new iteration. On the hierarchy of length scales certain unique entities can be identi fied. At the nanometer scale such functional entities are molecules and at the micrometer level these are the cells. Cells can be studied in vitro as independent individuals isolated from an organism, but their interplay and communication in vivo is crucial for tissue function. Control over such regulation mechanisms is therefore a main goal of medical research. The requirements for understanding cellular interplay also illustrate the interdisciplinarity of systems biology, because chemical, physical and biological knowledge is needed simultaneously. Following the notion of cells as the basic units of life, the focus of this thesis are mathematical multi-scale models of multi-cellular systems employing the concept of individual (or agent) based modeling (IBM). This concept accounts for the entity cell and their individuality in function and space. M.
Single-Cell-Based Models in Biology and Medicine
Author: Alexander Anderson
Publisher: Springer Science & Business Media
Published: 2007-08-08
Total Pages: 346
ISBN-13: 376438123X
DOWNLOAD EBOOKAimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.
Single-Cell-Based Models in Biology and Medicine
Author: Alexander Anderson
Publisher: Birkhäuser
Published: 2009-09-03
Total Pages: 349
ISBN-13: 9783764391836
DOWNLOAD EBOOKAimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.
Cell Mechanics
Author: Arnaud Chauvière
Publisher: CRC Press
Published: 2010-01-27
Total Pages: 484
ISBN-13: 1420094556
DOWNLOAD EBOOKUbiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior
A Structured Model for Individual Cell Growth
Author: Sa Van Ho
Publisher:
Published: 1976
Total Pages: 220
ISBN-13:
DOWNLOAD EBOOKModeling and Parameter Estimation for Heterogeneous Cell Populations
Author: Jan Hasenauer
Publisher: Logos Verlag Berlin GmbH
Published: 2013
Total Pages: 143
ISBN-13: 3832533982
DOWNLOAD EBOOKMost of the modeling performed in biology aims at achieving a quantitative description and understanding of the intracellular signaling pathways within a "typical cell". However, in many biologically important situations even genetically identical cell populations show a heterogeneous response. This means that individual members of the cell population behave differently. Such situations require the study of cell-to-cell variability and the development of models for heterogeneous cell populations. The main contribution of this thesis is the development of unifying modeling frameworks for signal transduction and proliferation processes in heterogeneous cell populations. These modeling frameworks allow for the detailed description of individual cells as well as differences between them. In contrast to many existing modeling approaches, the proposed frameworks allow for a direct comparison of model predictions with available data. Beyond this, the proposed population models can be simulated efficiently and, by exploiting the model structures, we are able to develop model-tailored Bayesian parameter estimation methods. These methods enable the calculation of the optimal parameter estimates, as well as the evaluation of the parameter and prediction uncertainties. The proposed tools allow for novel insights in population dynamics, in particular the model-based characterization of population heterogeneity and cellular subgroups. This is illustrated for two different application examples: pro- and anti-apoptotic signaling, which is interesting in the context of cancer therapy, and immune cell proliferation.
Spheroid Culture in Cancer Research (1991)
Author: Rolf Bjerkvig
Publisher: CRC Press
Published: 2017-11-22
Total Pages: 458
ISBN-13: 135135762X
DOWNLOAD EBOOKSpheroid Culture in Cancer Research describes the various techniques now available for establishing spheroid tissue culture, including spheroid culture from normal tissues and from tumor cell lines. The book also describes how the spheroid system can be used to study interactions between normal and malignant cells. Microenvironmental conditions in spheroids and how this micromilieu may promote cellular heterogeneity and histiotypic structures not observed in corresponding monolayer cultures are discussed. The biological importance of oxygen tension, pH gradients, diffusions of nutrients, and cell-cell communication in spheroids are also examined. The book will be profoundly important to researchers in experimental chemotherapy, radiotherapy, immunotherapy, and hyperthermia.
Simultaneous Mass Transfer and Chemical Reactions in Engineering Science
Author: Bertram K. C. Chan
Publisher: John Wiley & Sons
Published: 2023-02-01
Total Pages: 676
ISBN-13: 3527823514
DOWNLOAD EBOOKSimultaneous Mass Transfer and Chemical Reactions in Engineering Science A comprehensive look at the basic science of diffusional process and mass transfer Mass transfer as a principle is an essential part of numerous unit operations in biomolecular, chemical, and process engineering; crystallization, distillation, and membrane separation processes, for example, use this important method. Given this significance – particularly in engineering design where these processes occur – understanding the design and analysis of such unit operations must begin with a basic understanding of how simultaneous mass transfer and the chemical reactions that influence these occurrences. It is also vital to be aware of the most up-to-date technologies for analyzing and predicting the phenomena. Given the significance of this process, Simultaneous Mass Transfer and Chemical Reactions in Engineering Science is an important resource as it introduces the reader to the complex subject of simultaneous mass transfer with biochemical and chemical reactions and gives them the tools to develop an applicable design. Analyzing the systems of simultaneous mass transfer and reactions is at the core of this book, as all known design approaches are carefully examined and compared. The volume also provides the reader with a working knowledge of the latest technologies – with a special focus on the open-sourced computer programming language R – and how these tools are an essential resource in quantitative assessment in analysis models. Simultaneous Mass Transfer and Chemical Reactions in Engineering Science provides a working knowledge of the latest information on simultaneous mass transfer and reactions by focusing on the analysis of this process, as well as discussing the existence and distinctive quality of the solutions to the Simultaneous Mass Transfer and Chemical Reactions in Engineering Science readers will also find: A theoretical basis of each design model that is carefully stated, compared, and assessed Carefully developed and established Existence and Uniqueness Theorems for a general design model Comprehensive coverage of how the programming language R may be used to analyze models Numerous examples and case studies that provide a working knowledge of simultaneous mass transfer and reactions Simultaneous Mass Transfer and Chemical Reactions in Engineering Science is a useful reference for students in chemical engineering, biotechnology, or chemistry, as well as professional process and chemical engineers.
Contact Problems for Soft, Biological and Bioinspired Materials
Author: Feodor M. Borodich
Publisher: Springer Nature
Published: 2022-04-22
Total Pages: 299
ISBN-13: 3030851753
DOWNLOAD EBOOKThis book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects. Biologists, physicists, researchers applying methods of contact mechanics and researchers testing materials using indentation techniques along with many other applied scientists will find this book a useful addition to their libraries. Moreover, several reviews in this book are written as introductions to several important and rather sophisticated research areas such as depth-sensing indentation, studying of biological cells by AFM probes, mechanics of adhesive contact and contact between viscoelastic (hereditary elastic) solids. The book containing new theoretical models, results of experimental studies and numerical simulations, along with reviews of above mentioned areas of contact mechanics in application to biological systems, would be beneficial for researchers in many areas of biology, medicine, engineering, mechanics and biomimetics.
