Silicon-mediated Transformations of Functional Groups
Silicon-mediated Transformations of Functional Groups

Author: Helmut Vorbrueggen

Publisher: John Wiley & Sons

Published: 2006-03-06

Total Pages: 378

ISBN-13: 3527605924

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In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbrüggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis. Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods. The compact form and clear structure of this monograph make this a long-awaited ready reference. From the contents: Introduction * Techniques of Preparative Silylations-Desilylations * Preparation and Properties of Siliconoxy-Leaving Groups * Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide * Reactions of Aldehydes and Ketones * Reactions of Alcohols, Ethers and Epoxides * Reaction of N-O Systems * Reactions of S-O and Se-O Systems * Cyclizations and Ring Enlargements * Base and Acid-Catalyzed as well as Thermal Eliminations of Trimethylsilanol. Peterson Reactions * Formation of Carbon-Phosphorous Double- and Triple Bonds * Reductions and Oxidations * Dehydration-Activation as well as Silylation of Inorganic and Organic Salts and Metalorganic Compounds * Formation of Polymers

Comprehensive Organic Functional Group Transformations
Comprehensive Organic Functional Group Transformations

Author: Alan R. Katritzky

Publisher: Elsevier

Published: 1995

Total Pages: 1452

ISBN-13: 9780080423227

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This Volume covers the formation of carbon-carbon single-, double- and triple bonds by substitution and addition reactions as well as by various rearrangements. The formation of carbon-carbon multiple bonds by elimination and condensation procedures is fully documented. In addition the synthesis of carbon-hydrogen bonds principally by substitution and addition reactions is featured as is the preparation of a wide variety of carbon-centred anions, cations and radicals.

Comprehensive Organic Functional Group Transformations II
Comprehensive Organic Functional Group Transformations II

Author:

Publisher: Elsevier

Published: 2004-12-16

Total Pages: 9196

ISBN-13: 0080523471

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Comprehensive Organic Functional Group Transformations II (COFGT-II) will provide the first point of entry to the literature for all scientists interested in chemical transformations. Presenting the vast subject of organic synthesis in terms of the introduction and interconversion of all known functional groups, COFGT-II provides a unique information source documenting all methods of efficiently performing a particular transformation. Organised by the functional group formed, COFGT-II consists of 144 specialist reviews, written by leading scientists who evaluate and summarise the methods available for each functional group transformation. Also available online via ScienceDirect – featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com. By systematically treating each functional group in turn the work also identifies what is not known, thus pointing the way to new research areas Follows the systematic layout of the successful 1995 COFGT reference work, based on the arrangement and bonding of hetero-atoms around a central carbon atom The work will save researchers valuable time in their research as each chapter is written by experts who have critically read and reviewed the literature and presented the best methods of forming every known functional group

Reagents for Silicon-Mediated Organic Synthesis
Reagents for Silicon-Mediated Organic Synthesis

Author: Philip L. Fuchs

Publisher: John Wiley & Sons

Published: 2013-05-30

Total Pages: 816

ISBN-13: 1118636139

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Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry. For the selection the Editor focussed on three key syntheticapproaches with the greatest impact: 1. Use of silicon as a 'temporary tether' by unifying a reactivepair of functional groups and taking advantage of theirtemplate-biased intramolecular cyclization. 2. The specific use of the silane functionality as a heterot-butyl group, often colloquially referred to as the use ofsilicon as a 'fat proton'. 3. The use of the Brook rearrangement as an 'anion relaystratagem'. A new feature in this Handbook is the reagent finder, analphabetically organized lookup table arranged by organicfunctionality and specific structure of the silicon atom to whichit is bound.

Silicon in Organic Synthesis
Silicon in Organic Synthesis

Author: Ernest W. Colvin

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 361

ISBN-13: 148314223X

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Silicon in Organic Synthesis provides an introduction to the organic chemistry of silicon. This book places particular emphasis on the concept of silicon as a "ferryman, mediating the transformation of one wholly organic molecule into another. The book begins by reviewing the discovery and development of organosilicon compounds. This is followed by separate chapters on the physical properties of organosilicon compounds; the preparation of a-metallated organosilanes, which play a key role in preparative organosilicon chemistry; migration/rearrangement reactions of silicon; the preparation and chemistry of vinylsilanes, allylsilanes, arylsilanes, and organosilyl metallic compounds. Subsequent chapters cover the synthesis of compounds such as alkene, alkynylsilanes, allenylsilanes, silylketenes, alkyl silyl ethers, acyloxysilanes, and silyl enol ethers. This book aims to serve as a timely introduction to organic chemistry for students and practitioners of synthetic organic chemistry, as well as provide a source of useful information and possibly of new ideas to those already experienced in the area.

Name Reactions of Functional Group Transformations
Name Reactions of Functional Group Transformations

Author: Jie Jack Li

Publisher: John Wiley & Sons

Published: 2007-07-09

Total Pages: 768

ISBN-13: 9780470176504

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This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions.

Environmental Soil Properties and Behaviour
Environmental Soil Properties and Behaviour

Author: Raymond N. Yong

Publisher: CRC Press

Published: 2012-03-05

Total Pages: 458

ISBN-13: 1439845298

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From bridges and tunnels to nuclear waste repositories, structures require that soils maintain their design engineering properties if the structures are to reach their projected life spans. The same is true for earth dams, levees, buffers, barriers for landfills, and other structures that use soils as engineered materials. Yet soil, a natural resource, continues to change as a result of natural and anthropogenic stresses. As the discipline of soil properties and behaviours matures, new tools and techniques are making it possible to study these properties and behaviours in more depth. What Happens to Soil Under Weathering, Aging, and Chemical Stress? Environmental Soil Properties and Behaviour examines changes in soil properties and behaviour caused by short- and long-term stresses from anthropogenic activities and environmental forces. Introducing new concepts of soil behaviour, soil maturation, and soil functionality, it integrates soil physics, soil chemistry, and soil mechanics as vital factors in soil engineering. The book focuses on environmental soil behaviour, with particular attention to two main inter-related groups of soil–environment issues. The first is the use of soil as an environmental tool for management and containment of toxic and hazardous waste materials. The second is the impact of ageing and weathering processes and soil contamination on the properties and behaviour of soils, especially those used in geotechnical and geoenvironmental engineering projects. A Transdisciplinary Look at Soil-Changing Processes To determine short- and long-term soil quality and soil functionality, the authors emphasize the need to be aware of the nature of the stressors involved as well as the kinds of soil-changing processes that are evoked. This book takes a first step toward a much-needed transdisciplinary effort to develop a broader and deeper understanding of what happens to soil and how we can determine and quantify the effect of biogeochemical processes. It offers a timely resource for the study of soil properties and behaviours, effects of environmental changes, and remediation of contaminated soil.

Mesoporous Silica Nanoparticles
Mesoporous Silica Nanoparticles

Author: Sachin Namdeo Kothawade

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2024-11-18

Total Pages: 410

ISBN-13: 3111338495

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Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.