This revised and updated second edition contains multiple microscopic illustrations of all diagnostic entities and ancillary techniques, providing a comprehensive, authoritative guide to all aspects of serous effusions. It now includes the many new antibodies which have been tested since the previous edition, as well as a discussion on next-generation sequencing and molecularly targeted therapy. Section one covers diagnosis for benign and malignant effusions while section two discusses biology, therapy, and prognosis highlighting clinical approaches that may be of value. Serous Effusions provides an indispensable guide to all aspects of current practice for cytopathologists, cytotechnicians, pathologists, clinicians and researchers in training and practice.
This book is the culmination of an international effort to bring consistency and diagnostic efficiency to effusion cytology for the sake of patient care. The authors recognize special challenges in serous fluid cytopathology, such as reporting the presence of Mullerian epithelium in peritoneal fluids. What is an appropriate serous fluid volume to ensure adequacy? How should mesothelial proliferations be reported and is it appropriate to make an interpretation of malignant mesothelioma? How specific should a report be regarding the origin and subtyping of tumors found in serous fluids? What are the appropriate quality monitors for this specimen type? Special chapters on considerations for peritoneal washings, cytopreparatory techniques, mesothelioma and quality management are included to address these issues. The text contains literature reviews that elucidate existing evidence in support of current practices and recommendations. Expert opinions on where evidence was lacking, the most common practices were adopted by consensus, and where there was no commonality, are employed. Written by experts in the field, The International System for Serous Fluid Cytopathology serves as a collaborative effort between the International Academy of Cytology and the American Society for Cytopathology and calls upon participation of the international cytopathology and oncology communities to contribute to the development of a truly international system for reporting serous fluid cytology
Cytologic diagnosis by examination of exfoliated cells in serous cavity fluids is one of the most challenging areas in clinical cytopathology. Almost 20% of the effusions examined are directly or indirectly related to the presence of malignant disease, with carcinoma of the lung as the most common underlying culprit. This volume published in the Essentials in Cytopathology book series will fulfill the need for an easy-to-use and authoritative synopsis of site specific topics in cytopathology. These guide books fit into the lab coat pocket, ideal for portability and quick reference. Each volume is heavily illustrated with a full color art program, while the text follows a user-friendly outline format.
It is hoped that this book may serve two purposes. felt that the resulting increase in size and expense of First it is intended for use at the bench. to help solve the book would not be justified. some of the problems of cell identification which The material was collected over many years and puzzle not only beginners. but even experienced we cannot individually acknowledge the great contri observers in the field of cytological diagnosis. Sec bution made by technical staff of the clinical cytology ondly we have reviewed the most significant previous laboratories who assisted the two authors to prepare publications. particularly those of the past 20 years. and stain the sl ides. Most of the electron micrographs so as to provide a source of reference. were made by or with the assistance of the late Denis Cytological diagnosis should not be isolated from W. Jerrome. and we are also grateful to Dr David histopathology. and many readers will regret the lack Ferguson for further help and advice with these. All of the immunocytochemical stains were done by Dr of cyto-histological correlation in our choice of photographs. Cells centrifuged out of suspension in Anna Ghosh. and Drs David Mason and Kevin Gatter pathological fluids bear very little resemblance to kindly commented on that part of the manuscript. their counterparts in tissue sections.
Cytology is a unique subspecialty in anatomic pathology, and plays a critical role in the diagnosis of a variety of benign and malignant lesions by using minimally invasive procedures, such as fine needle aspiration, brushing, washing and lavage. Cytology not only provides an accurate diagnosis of the lesion based on the cytomorphological evaluation at cellular level, but also provides material for molecular characterization of a tumor for targeted therapy. In the era of personalized medicine, cytology has continued to grow and evolve as an important diagnostic tool. For example, some types of procedures are routinely used, diagnostic criteria have become more refined, and certain terminology has been changed based on current WHO classifications. Therefore, it is necessary to update our knowledge and terminology in cytology. In this volume, we have retained the quality and the clarity of the series, and like the other volumes, this volume aims to be concise and comprehensive yet clinically relevant to daily practice. Although this volume is written by multiple authors, all chapters follow a similar format: brief introduction of the specific organ/system (including types of specimens and techniques to obtain samples), description of normal findings, and a practice approach to diagnose benign and malignant lesions. In each chapter, the key cytomorphological feature and main differential diagnoses of the lesion are summarized in a concise table. Images in each chapter are instructive and clearly represent findings. Where necessary, we have also illustrated the important ancillary tests, such as flow cytometry, immunohistochemistry and molecular analysis, which are crucial for an accurate diagnosis and targeted therapy. The updated knowledge, including key cytomorphological features, current terminology and molecular diagnostic tests, is the highlight of this volume.
This new reference examines specimen processing of effusion fluids, detailing the steps needed to obtain more accurate diagnoses while avoiding common pitfalls. A methodical, algorithmic approach to the evaluation and interpretation of specimens enables you to establish a definitive diagnosis in these often difficult cases. User-friendly features - combined with extensive tables and algorithms - facilitate ease of interpretation, and highlighted information makes the most essential concepts easy to reference quickly. Avoid potential errors in diagnosis with a full chapter that offers expert approaches to specimen collection and processing. Arrive at more accurate diagnoses with the aid of step-by-step algorithms plus hundreds of illustrations - including multiple images for each phenomenon representing a broad range of stains and magnifications. Achieve optimal diagnostic certainty by viewing correlations between Pap, Diff-Quick (Romanowsky), and immunocytochemical stain for every type of serous effusion. Recognize the difference in cell samples yielded after washing the serous cavity with saline or balanced salt solution versus effusion fluid. Understand the advantages and disadvantages of Pap stains versus Diff-Quick stains in FNA evaluations. Remain up to date with the latest technologies such as liquid based cytology (SurePathTM) and ThinPrepTM. Easily apply principles to real-life practice by reviewing detailed histories. Quickly locate the guidance you need with a color-coded chapter system. Focus on the most important points with user-friendly highlighted boxes.
Cytopathology provides a wide-ranging overview of the microscopic study of normal and abnormal cells, showing how current visualization methods are used to study cell structure, and how early detection of abnormal cell pathology can lead to timely clinical interventions.
With portable, hand-carried ultrasound devices being more frequently implemented in medicine today, Point-of-Care Ultrasound will be a welcome resource for any physician or health care practitioner looking to further their knowledge and skills in point-of-care ultrasound. This comprehensive, portable handbook offers an easy-access format that provides comprehensive, non-specialty-specific guidance on this ever-evolving technology. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Access all the facts with focused chapters covering a diverse range of topics, as well as case-based examples that include ultrasound scans. Understand the pearls and pitfalls of point-of-care ultrasound through contributions from experts at more than 30 institutions. View techniques more clearly than ever before. Illustrations and photos include transducer position, cross-sectional anatomy, ultrasound cross sections, and ultrasound images.
