An exploration of the interrelated fields of design of experiments and sequential analysis with emphasis on the nature of theoretical statistics and how this relates to the philosophy and practice of statistics.
This book serves well as an introduction into the more theoretical aspects of the use of spline models. It develops a theory and practice for the estimation of functions from noisy data on functionals. The simplest example is the estimation of a smooth curve, given noisy observations on a finite number of its values. The estimate is a polynomial smoothing spline. By placing this smoothing problem in the setting of reproducing kernel Hilbert spaces, a theory is developed which includes univariate smoothing splines, thin plate splines in d dimensions, splines on the sphere, additive splines, and interaction splines in a single framework. A straightforward generalization allows the theory to encompass the very important area of (Tikhonov) regularization methods for ill-posed inverse problems. Convergence properties, data based smoothing parameter selection, confidence intervals, and numerical methods are established which are appropriate to a wide variety of problems which fall within this framework. Methods for including side conditions and other prior information in solving ill-posed inverse problems are included. Data which involves samples of random variables with Gaussian, Poisson, binomial, and other distributions are treated in a unified optimization context. Experimental design questions, i.e., which functionals should be observed, are studied in a general context. Extensions to distributed parameter system identification problems are made by considering implicitly defined functionals.
A concise survey of the current state of knowledge in 1972 about solving elliptic boundary-value eigenvalue problems with the help of a computer. This volume provides a case study in scientific computing?the art of utilizing physical intuition, mathematical theorems and algorithms, and modern computer technology to construct and explore realistic models of problems arising in the natural sciences and engineering.
This book uses fundamental ideas in dynamical systems to answer questions of a biologic nature, in particular, questions about the behavior of populations given a relatively few hypotheses about the nature of their growth and interaction. The principal subject treated is that of coexistence under certain parameter ranges, while asymptotic methods are used to show competitive exclusion in other parameter ranges. Finally, some problems in genetics are posed and analyzed as problems in nonlinear ordinary differential equations.