Aptamers Selected by Cell-SELEX for Theranostics
Aptamers Selected by Cell-SELEX for Theranostics

Author: Weihong Tan

Publisher: Springer

Published: 2015-03-02

Total Pages: 352

ISBN-13: 3662462265

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This edited volume describes cell-SELEX as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, aptamers can be effectively used in theranostics, bioanalysis, environment detection and biomedical studies. The book gathers reviews that reflect the latest advances in the field of aptamers and consists in fourteen chapters demonstrating essential examples of these aptamers and aptamer-nanomaterial assemblies, depending on the types of applications and biological systems. It also includes a separate chapter on the utilization of aptamers in real clinics and what will be required to achieve this significant goal. The book will be both appealing and useful to a broad audience, including biologists, bioscientists, and clinicians whose interests range from chemistry and biomedical engineering to cell and molecular biology and biotechnology. Weihong Tan is a Distinguished Professor of Chemistry and Biomedical Engineering at Hunan University, China and also a University of Florida Distinguished Professor and V.T. and Louis Jackson Professor of Chemistry at the University of Florida, USA. Xiaohong Fang is a Professor at the Institute of Chemistry, Chinese Academy of Sciences, China.

Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques
Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques

Author: James P. Landers

Publisher: CRC Press

Published: 2007-12-18

Total Pages: 1598

ISBN-13: 1420004956

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Now in its third edition, this bestselling work continues to offer state-of-the-art information on the development and employment of capillary electrophoresis. With special emphasis on microseparations and microfluidics, it features new chapters describing the use of microchip electrophoresis and associated microtechniques, with a focus on the extraordinary breadth of work undertaken to expand CE methodologies in recent years. Enhanced by contributions from leading international experts, the Handbook of Capillary and Microchip Electrophoresis and Associated Microtechniques, Third Edition remains a seminal reference for the chemistry, biology, and engineering fields.

Aptamers for Analytical Applications
Aptamers for Analytical Applications

Author: Yiyang Dong

Publisher: John Wiley & Sons

Published: 2019-02-11

Total Pages: 426

ISBN-13: 3527342672

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An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.

Aptasensors for Food Safety
Aptasensors for Food Safety

Author: Raju Khan

Publisher: CRC Press

Published: 2024-10-04

Total Pages: 547

ISBN-13: 1040118607

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This reference book provides updated knowledge on fundamentals and applications of aptasensors in food science. It discusses aptamer selection strategies including Systematic Evolution of Ligands through EXponential enrichment (SELEX), Capture SELEX, Cell SELEX, and GO SELEX strategies for aptasensor design involving well-studied and newly emerged nanomaterials, food analysis focusing on its safety, aptasensing techniques relevant to detection of food pathogens, pesticides, veterinary drug residues, toxins, heavy metals, allergens, and future perspectives of aptamers in food science and technology. The book focuses on recent developments in aptasensors and their use in detection of contaminants in food. The book is an excellent resource for R&D organizations dedicated to the development of biosensors in general and aptasensors in particular for the detection of environmental contaminants in the food supply chain. Also, the contents of the book will be useful to researchers, postgraduate students, analytical chemists, food scientists, and regulatory authorities.

Handbook of Smart Materials in Analytical Chemistry
Handbook of Smart Materials in Analytical Chemistry

Author: Miguel de la Guardia

Publisher: John Wiley & Sons

Published: 2019-01-24

Total Pages: 996

ISBN-13: 1119422590

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A comprehensive guide to smart materials and how they are used in sample preparation, analytical processes, and applications This comprehensive, two-volume handbook provides detailed information on the present state of new materials tailored for selective sample preparation and the legal frame and environmental side effects of the use of smart materials for sample preparation in analytical chemistry, as well as their use in the analytical processes and applications. It covers both methodological and applied analytical aspects, relating to the development and application of new materials for solid-phase extraction (SPE) and solid-phase microextraction (SPME), their use in the different steps and techniques of the analytical process, and their application in specific fields such as water, food, air, pharmaceuticals, clinical sciences and forensics. Every chapter in Handbook of Smart Materials in Analytical Chemistry is written by experts in the field to provide a comprehensive picture of the present state of this key area of analytical sciences and to summarize current applications and research literature in a critical way. Volume 1 covers New Materials for Sample Preparation and Analysis. Volume 2 handles Analytical Processes and Applications. Focuses on the development and applications of smart materials in analytical chemistry Covers both, methodological and applied analytical aspects, for the development of new materials and their use in the different steps and techniques of the analytical process and their application in specific fields Features applications in key areas including water, air, environment, pharma, food, forensic, and clinical Presents the available tools for the use of new materials suitable to aid recognition process to the sample preparation and analysis A key resource for analytical chemists, applied laboratories, and instrument companies Handbook of Smart Materials in Analytical Chemistry, 2V Set is an excellent reference book for specialists and advanced students in the areas of analytical chemistry, including both research and application environments.

Aptamers Engineered Nanocarriers for Cancer Therapy
Aptamers Engineered Nanocarriers for Cancer Therapy

Author: Prashant Kesharwani

Publisher: Woodhead Publishing

Published: 2022-09-25

Total Pages: 558

ISBN-13: 0323855768

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Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers – such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy. - Reviews the mechanisms behind multi-drug resistance (MDR) in cancer and how aptamer-mediated novel therapeutic agents and strategies can facilitate MDR reversal - Covers a range of aptamers engineered nanostructures, including PLGA nanoparticles, silica nanoparticles, quantum dots, nucleic acid aptamers, and more - Discusses the challenges associated with using aptamers as cancer therapeutics and how this translates into clinical use

Rapid Antigen Testing
Rapid Antigen Testing

Author: Laura Anfossi

Publisher: BoD – Books on Demand

Published: 2023-10-04

Total Pages: 178

ISBN-13: 1837695687

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Rapid antigen tests became popular during the COVID-19 pandemic as affordable diagnostic tools to help control the spread of infection, thanks to their cost-effectiveness and simplicity of use. These features enabled their widespread employment at point-of-care, even in those countries where access to care is still limited. The advantages of this diagnostic approach have been demonstrated in practical applications and have envisaged their utilization in other diagnostic fields in which access to prevention is beneficial, such as in the fight against neglected diseases and cancer. As such, the need to further improve the performance of rapid antigen assays is urgent. At the same time, the replacement of natural bioligands with synthetic ones to increase sustainability is likely to support the future development of the technique. The boundaries of applications of rapid antigen tests are still expanding towards several fields, beyond clinical diagnostics to food safety, forensics, and veterinary testing. This book provides a comprehensive overview of rapid antigen testing, discussing both its benefits and limitations.