Guide for the Care and Use of Laboratory Animals

Guide for the Care and Use of Laboratory Animals

Author: National Research Council

Publisher: National Academies Press

Published: 2011-01-27

Total Pages: 246

ISBN-13: 0309154006

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A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.


Use of Laboratory Animals in Biomedical and Behavioral Research

Use of Laboratory Animals in Biomedical and Behavioral Research

Author: National Research Council

Publisher: National Academies Press

Published: 1988-02-01

Total Pages: 113

ISBN-13: 0309038391

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Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.


Genetics and the Behavior of Domestic Animals

Genetics and the Behavior of Domestic Animals

Author: Temple Grandin

Publisher: Academic Press

Published: 2013-04-22

Total Pages: 496

ISBN-13: 0124055087

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Behavior is shaped by both genetics and experience--nature and nurture. This book synthesizes research from behavioral genetics and animal and veterinary science, bridging the gap between these fields. The objective is to show that principles of behavioral genetics have practical applications to agricultural and companion animals. The continuing domestication of animals is a complex process whose myriad impacts on animal behavior are commonly under-appreciated. Genetic factors play a significant role in both species-specific behaviors and behavioral differences exhibited by individuals in the same species. Leading authorities explore the impact of increased intensities of selection on domestic animal behavior. Rodents, cattle, pigs, sheep, horses, herding and guard dogs, and poultry are all included in these discussions of genetics and behavior, making this book useful to veterinarians, livestock producers, laboratory animal researchers and technicians, animal trainers and breeders, and any researcher interested in animal behavior. - Includes four new chapters on dog and fox behavior, pig behavior, the effects of domestication and horse behavior - Synthesizes research from behavioral genetics, animal science, and veterinary literature - Broaches fields of behavior genetics and behavioral research - Includes practical applications of principles discovered by behavioral genetics researchers - Covers many species ranging from pigs, dogs, foxes, rodents, cattle, horses, and cats


Laboratory Animal Medicine

Laboratory Animal Medicine

Author: Lynn C. Anderson

Publisher: Academic Press

Published: 2002-06-20

Total Pages: 1345

ISBN-13: 008053533X

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A volume in the American College of Laboratory Animal Medicine series, this second edition has over 40% new material, including the addition of six new topics and many others that are completely rewritten. The book comprehensively covers the biological and disease aspects of laboratory animal medicine while examining other aspects such as the biohazards associated with the use of animal experimentation and factors complicating the bioethics of animal research.


The Laboratory Mouse

The Laboratory Mouse

Author: Hans Hedrich

Publisher: Academic Press

Published: 2012-06-14

Total Pages: 869

ISBN-13: 012382009X

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The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. - Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research - Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology - Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries


Principles of Animal Research for Graduate and Undergraduate Students

Principles of Animal Research for Graduate and Undergraduate Students

Author: Mark A. Suckow

Publisher: Academic Press

Published: 2016-11-16

Total Pages: 288

ISBN-13: 012802366X

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Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher's education. - Provides background material for students to understand the broader backdrop against which animal research is undertaken - Includes ethical and regulatory information - Covers commonly used animal models and the process to choose a model for biomedical research


Introduction to Laboratory Animal Science and Technology

Introduction to Laboratory Animal Science and Technology

Author: J. K. Inglis

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 351

ISBN-13: 1483279774

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Introduction to Laboratory Animal Science and Technology discusses the principles involved in the healthy maintenance of animals in the laboratory or animal house. This book is divided into eight six units of study of the physical requirements of animals, physiological data, and techniques of husbandry, followed by summary data capsules and recommended further reading. After an overview of the laboratory animals, this book goes on dealing with various aspects of animal care, including their accommodation, health care routine, and animal health and hygiene. The next chapters examine the components of animal diet, the biological aspects of animal reproduction, breeding and heredity. The final chapter emphasizes the legal requirements concerning anesthesia, laboratory procedures, and the issue of euthanasia. This book will prove useful to laboratory technicians, students, students, researchers, and the general public who are concerned for animals and their use in laboratory work.


The Design of Animal Experiments

The Design of Animal Experiments

Author: Michael Festing

Publisher: SAGE Publications Limited

Published: 2016-12-14

Total Pages: 0

ISBN-13: 9781473974630

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Where there is no alternative to the use of animals in biomedical research, it is important that experiments are well designed and correctly analysed in order to minimise pain and maximize the chance of getting scientifically valid results. Experiments that use too few animals may fail to pick up biologically important effects, while those who use them incorrectly or wastefully may get invalid results while subjecting the animals to unnecessary pain, distress or lasting harm. The Design of Animal Experiments is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively and/or to improve their ability to communicate with professional statisticians when necessary. It covers all randomised controlled experimental designs likely to be needed in laboratory animal research, with worked examples showing how they can be statistically analysed. It suggests the more widespread use of randomised block designs and shows how both males and females can be included in an experiment without the need to increase the total number of animals by using factorial designs. It also includes guidance on the choice of experimental animals. The book covers the learning outcomes of Module 10 and part (ii) of Module 11 of education and training under Directive 2010/63/EU.


Background Lesions in Laboratory Animals E-Book

Background Lesions in Laboratory Animals E-Book

Author: Elizabeth Fiona McInnes

Publisher: Elsevier Health Sciences

Published: 2011-10-24

Total Pages: 141

ISBN-13: 0702049247

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Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. - over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits - a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals - a chapter on common artifacts that may be observed in histological glass slides - extensive references to each lesion described - aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies