Magnesium in the Central Nervous System
Magnesium in the Central Nervous System

Author: Robert Vink

Publisher: University of Adelaide Press

Published: 2011

Total Pages: 354

ISBN-13: 0987073052

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The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

First Episode Psychosis
First Episode Psychosis

Author: Katherine J. Aitchison

Publisher: CRC Press

Published: 1999-02-17

Total Pages: 152

ISBN-13: 9781853174353

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The new edition of this popular handbook has been thoroughly updated to include the latest data concerning treatment of first-episode patients. Drawing from their experience, the authors discuss the presentation and assessment of the first psychotic episode and review the appropriate use of antipsychotic agents and psychosocial approaches in effective management.

Curing Bipolar Disorder and Schizophrenia
Curing Bipolar Disorder and Schizophrenia

Author: Doris Denise King

Publisher:

Published: 2009-09

Total Pages: 104

ISBN-13: 9780982485309

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Based on the work and research of the late Dr. John Lee, "Curing Bipolar Disorder and Schizophrenia" explains the importance of hormone balance to mental health and describes what can happen in the brain and body when they don't have the progesterone they need.

Oxford Textbook of Cognitive Neurology and Dementia
Oxford Textbook of Cognitive Neurology and Dementia

Author: Masud Husain

Publisher: Oxford University Press

Published: 2018-10-29

Total Pages: 513

ISBN-13: 0198831080

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This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.

Psychiatric Genetics and Genomics
Psychiatric Genetics and Genomics

Author: Peter McGuffin

Publisher: Oxford University Press

Published: 2004-09-23

Total Pages: 508

ISBN-13: 9780198564867

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From reviews of the hardback:'It is timely to see such an excellent textbook... Aimed at graduate level students, this book is complex enough to be thorough, but clear with enough background to be accessible... the coverage is comprehensive and the flow logical... The text is uniformly well written and achieves a successful integration.' -The Lancet'A good introduction and reference book for professionals interested in psychiatric genetics such as psychiatrists, clinical psychologists and neuroscientists... the book you want to have on your bookshelf to look up material and obtain a complete and balanced picture of the field.' -Psychological MedicineRevised for paperback edition, with new appendicesGenetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations.The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future.The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors.Readership: Psychiatrists, clinical psychologists, geneticists, neuroscientists and neurologists

The Natural History of Mania, Depression, and Schizophrenia
The Natural History of Mania, Depression, and Schizophrenia

Author: George Winokur

Publisher: American Psychiatric Pub

Published: 1996

Total Pages: 396

ISBN-13: 9780880487269

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The Natural History of Mania, Depression, and Schizophrenia takes an unusual look at the course of mental illness, based on data from the Iowa 500 Research Project. This project involved the long-term (30-40 years) follow-up of patients diagnosed with schizophrenia, depression, and bipolar illness. After presenting a history and background of the study, the authors provide fascinating, verbatim interviews with patients at the time of hospital admission in the 1930s and 1940s. Eight of the 15 chapters are dedicated to the modern, systematic follow-up and family study of these patients. Medical students, residents, psychiatrists, social workers, psychologists, ministers, and clinicians are offered an interesting look at what might be expected should treatment not be instituted with such patients. Unlike earlier works that focused on the descriptive aspects of mental illness, this book provides clinicians with a more systematic evaluation of the symptom picture, course and outcome, and family history. It concludes with useful information on the diagnosis and classification of the affective disorders and chronic nonaffective psychoses.

Neurological, Psychiatric, and Developmental Disorders
Neurological, Psychiatric, and Developmental Disorders

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2001-01-01

Total Pages: 458

ISBN-13: 0309170931

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Brain disordersâ€"neurological, psychiatric, and developmentalâ€"now affect at least 250 million people in the developing world, and this number is expected to rise as life expectancy increases. Yet public and private health systems in developing countries have paid relatively little attention to brain disorders. The negative attitudes, prejudice, and stigma that often surround many of these disorders have contributed to this neglect. Lacking proper diagnosis and treatment, millions of individual lives are lost to disability and death. Such conditions exact both personal and economic costs on families, communities, and nations. The report describes the causes and risk factors associated with brain disorders. It focuses on six representative brain disorders that are prevalent in developing countries: developmental disabilities, epilepsy, schizophrenia, bipolar disorder, depression, and stroke. The report makes detailed recommendations of ways to reduce the toll exacted by these six disorders. In broader strokes, the report also proposes six major strategies toward reducing the overall burden of brain disorders in the developing world.

Hidden Valley Road
Hidden Valley Road

Author: Robert Kolker

Publisher: Anchor

Published: 2020-04-07

Total Pages: 427

ISBN-13: 0385543778

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#1 NEW YORK TIMES BESTSELLER • OPRAH’S BOOK CLUB PICK • ONE OF GQ's TOP 50 BOOKS OF LITERARY JOURNALISM IN THE 21st CENTURY • The heartrending story of a midcentury American family with twelve children, six of them diagnosed with schizophrenia, that became science's great hope in the quest to understand the disease. "Reads like a medical detective journey and sheds light on a topic so many of us face: mental illness." —Oprah Winfrey Don and Mimi Galvin seemed to be living the American dream. After World War II, Don's work with the Air Force brought them to Colorado, where their twelve children perfectly spanned the baby boom: the oldest born in 1945, the youngest in 1965. In those years, there was an established script for a family like the Galvins--aspiration, hard work, upward mobility, domestic harmony--and they worked hard to play their parts. But behind the scenes was a different story: psychological breakdown, sudden shocking violence, hidden abuse. By the mid-1970s, six of the ten Galvin boys, one after another, were diagnosed as schizophrenic. How could all this happen to one family? What took place inside the house on Hidden Valley Road was so extraordinary that the Galvins became one of the first families to be studied by the National Institute of Mental Health. Their story offers a shadow history of the science of schizophrenia, from the era of institutionalization, lobotomy, and the schizophrenogenic mother to the search for genetic markers for the disease, always amid profound disagreements about the nature of the illness itself. And unbeknownst to the Galvins, samples of their DNA informed decades of genetic research that continues today, offering paths to treatment, prediction, and even eradication of the disease for future generations. With clarity and compassion, bestselling and award-winning author Robert Kolker uncovers one family's unforgettable legacy of suffering, love, and hope.

Schizophrenia Is a Misdiagnosis
Schizophrenia Is a Misdiagnosis

Author: C. Raymond Lake

Publisher: Springer Science & Business Media

Published: 2012-03-21

Total Pages: 442

ISBN-13: 1461418704

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Schizophrenia is the most widely known and feared mental illness worldwide, yet a rapidly growing literature from a broad spectrum of basic and clinical disciplines, especially epidemiology and molecular genetics, suggests that schizophrenia is the same condition as a psychotic bipolar disorder and does not exist as a separate disease. The goal is to document and interpret these data to justify eliminating the diagnosis of schizophrenia from the nomenclature. The author reviews the changing diagnostic concepts of schizophrenia and bipolar disorder with a historical perspective to clarify how the current conflict over explanations for psychosis has arisen. That two disorders, schizophrenia and bipolar, known as the Kraepelinian dichotomy, account for the functional psychoses has been a cornerstone of Psychiatry for over 100 years, but is questioned because of substantial similarities and overlap between these two disorders. Literature in the field demonstrates that psychotic patients are frequently misdiagnosed as suffering from the disease called schizophrenia when they suffer from a psychotic mood disorder. Such patients, their families, and their caretakers suffer significant disadvantages from the misdiagnosis. Psychotic patients misdiagnosed with schizophrenia receive substandard care regarding their medications, thus allowing their bipolar conditions to worsen. Other adverse effects are substantial and will be included. Liability for medical malpractice is of critical importance for the mental health professionals who make the majority of the diagnoses of schizophrenia. The concept put forward in this work will have a discipline-altering impact.