Methods and Applications of Statistics in Clinical Trials, Volume 2

Methods and Applications of Statistics in Clinical Trials, Volume 2

Author: Narayanaswamy Balakrishnan

Publisher: John Wiley & Sons

Published: 2014-06-16

Total Pages: 953

ISBN-13: 1118595963

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Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features: • Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems • Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index • Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials


Regression Modeling Strategies

Regression Modeling Strategies

Author: Frank E. Harrell

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 583

ISBN-13: 147573462X

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Many texts are excellent sources of knowledge about individual statistical tools, but the art of data analysis is about choosing and using multiple tools. Instead of presenting isolated techniques, this text emphasizes problem solving strategies that address the many issues arising when developing multivariable models using real data and not standard textbook examples. It includes imputation methods for dealing with missing data effectively, methods for dealing with nonlinear relationships and for making the estimation of transformations a formal part of the modeling process, methods for dealing with "too many variables to analyze and not enough observations," and powerful model validation techniques based on the bootstrap. This text realistically deals with model uncertainty and its effects on inference to achieve "safe data mining".


Multivariable Analysis

Multivariable Analysis

Author: Alvan R. Feinstein

Publisher: Yale University Press

Published: 1996-01-01

Total Pages: 644

ISBN-13: 0300062990

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A physician with wide experience in both clinical work and research, Dr. Feinstein succeeds in demystifying arcane vocabulary and unfamiliar mathematics. His book is a roadmap taking the reader from the basics of univariate and bivariate statistics, through methods of converting information into data coded for computers, and on to multivariable statistics. Dr.


The Little SAS Book

The Little SAS Book

Author: Lora D. Delwiche

Publisher: SAS Institute

Published: 2019-10-11

Total Pages: 512

ISBN-13: 1642953431

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A classic that just keeps getting better, The Little SAS Book is essential for anyone learning SAS programming. Lora Delwiche and Susan Slaughter offer a user-friendly approach so that readers can quickly and easily learn the most commonly used features of the SAS language. Each topic is presented in a self-contained, two-page layout complete with examples and graphics. Nearly every section has been revised to ensure that the sixth edition is fully up-to-date. This edition is also interface-independent, written for all SAS programmers whether they use SAS Studio, SAS Enterprise Guide, or the SAS windowing environment. New sections have been added covering PROC SQL, iterative DO loops, DO WHILE and DO UNTIL statements, %DO statements, using variable names with special characters, the ODS EXCEL destination, and the XLSX LIBNAME engine. This title belongs on every SAS programmer's bookshelf. It's a resource not just to get you started, but one you will return to as you continue to improve your programming skills. Learn more about the updates to The Little SAS Book, Sixth Edition here. Reviews for The Little SAS Book, Sixth Edition can be read here.


Practical Handbook of Spatial Statistics

Practical Handbook of Spatial Statistics

Author: Sandra Arlinghaus

Publisher: CRC Press

Published: 2020-08-26

Total Pages: 324

ISBN-13: 1000102017

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The guidance and special techniques provided in this handbook will allow you to understand and use complex spatial statistical techniques. You will learn how to apply proper spatial analysis techniques and why they are generally different from conventional statistical analyses. Clear and concise information on weighting, aggregation effects, sampling, spatial statistics and GIS, and visualization of spatial dependence is provided. Discussions on specific applications using actual data sets fill obvious gaps in the literature, and coverage of critical research frontiers allows readers to explore current areas of active research.


Handbook of Bioequivalence Testing

Handbook of Bioequivalence Testing

Author: Sarfaraz K. Niazi

Publisher: CRC Press

Published: 2014-10-29

Total Pages: 992

ISBN-13: 1482226383

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As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have m