The Development of the Sarcoplasmic Reticulum
The Development of the Sarcoplasmic Reticulum

Author: Anthony Martonosi

Publisher: CRC Press

Published: 2003-09-02

Total Pages: 707

ISBN-13: 0203305019

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Sarcoplasmic reticulum is a form of endoplasmic reticulum found in large quantities in mature muscle cells. Anthony Martonosi presents general information about the development and function of the sarcoplasmic reticulum within a framework of contemporary research on the molecular biology of biosynthetic and signaling processes. Focusing on the development of the sarcoplasmic reticulum, Martonosi demonstrates the regulatory functions that control the production of its molecular components and investigates the interaction of these lipid and protein molecules with the myogenic, neurogenic and hormonal stimuli present in developing muscle cells. Martonosi provides extensive experimental support throughout the book.

Sarcoplasmic Reticulum
Sarcoplasmic Reticulum

Author: Rigers Bakiu

Publisher: Nova Science Publishers

Published: 2015

Total Pages: 0

ISBN-13: 9781634828390

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Muscle cells, including cardiomyocytes, contain a specialized smooth endoplasmic reticulum (ER), sarcoplasmic reticulum (SR) calcium ions (Ca2+) release and reuptake by the sarcoplasmic reticulum trigger the contraction and relaxation of the myofibrils, respectively. This book examines the control and modulation of the SR and how this may vary among skeletal and cardiac muscle without bypassing the smooth muscle. It presents new and exciting work in this area and identifies promising new research directions. Furthermore, it considers the advances in this relatively unexplored field, offering new insights into the role of SR communication with other organelles and the new concepts about ER stress. Generally, this scientific book brings together contributions from key workersboth in basic and clinical sciences whose studies range from physiological to pathological and molecular to whole animal. In this book, the authors provide insights into the evolution of SR design and function.

Functional Ultrastructure
Functional Ultrastructure

Author: Margit Pavelka

Publisher: Springer Science & Business Media

Published: 2010-07-16

Total Pages: 366

ISBN-13: 3211993908

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The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.

Structure and Function of Sarcoplasmic Reticulum
Structure and Function of Sarcoplasmic Reticulum

Author: Sidney Fleischer

Publisher: Academic Press

Published: 2013-10-22

Total Pages: 636

ISBN-13: 1483277445

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Structure and Function of Sarcoplasmic Reticulum is a compendium of papers from an International Conference on Sarcoplasmic Reticulum held in Japan on November 1-4, 1982. Section I is a review of sarcoplasmic reticulum including the "discovery" of the relaxing factor, the calcium binding of relaxing factor, as well as phosphate transfer and calcium transport coupling. Section II involves the chemistry and structure of the calcium pump protein in sarcoplasmic reticulum. One paper describes the role of protein-lipid interactions in the organization and function of biomembranes. Section III considers the kinetics and thermodynamics of the calcium pumping mechanism, particularly the binding of ligands to calcium ATPase of the sarcoplasmic reticulum, as well as the conformational changes of the sarcoplasmic reticulum Ca-ATPase induced by substrate binding and phosphorylation. A paper gives the results of several experimental techniques in substrates binding assays employing millipore filters and a thermostated filtration apparatus. Section IV describes the calcium ions release process such as rapid and reversible actions, while Section V discusses the regulation of calcium ions uptake and release in the ion channel vesicles. This book can be helpful for researchers in biophysical engineering, pharmacologists, and scientists in the fields of biochemistry and biophysics.

Role of the Sarcoplasmic Reticulum in Smooth Muscle
Role of the Sarcoplasmic Reticulum in Smooth Muscle

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

Published: 2003-07-07

Total Pages: 296

ISBN-13: 0470852933

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Smooth muscle contraction is a vital component of the functioning of blood vessels, the uterus, airways and the bladder. Its malfunction can lead to serious pathological conditions, such as hypertension and pre-term labour. The calcium ion plays a central role in smooth muscle function, increasing in concentration for contraction and decreasing for relaxation. Calcium entry into the cell is facilitated by the sarcoplasmic reticulum (SR). This book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of the SR and how this may vary among smooth muscle types. Potential therapeutic implications are also discussed. Discusses new and exciting work in this area and identifies promising new research directions. Considers the advances in this relatively unexplored field, offering new insights into the role of the SR muscle. Brings together contributions from key workers, both in basic and clinical science, whose studies range from physiological to pathological and molecular to whole animal.

Biochemistry of Smooth Muscle Contraction
Biochemistry of Smooth Muscle Contraction

Author: Michael Barany

Publisher: Elsevier

Published: 1996-01-04

Total Pages: 455

ISBN-13: 0080527892

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This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.

Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle
Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle

Author: George B. Frank

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 450

ISBN-13: 1461533627

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The Third International Symposium on Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle, organized by George Frank, C. Paul Bianchi, and Henk E. DJ. ter Keurs, was held in Banff Centre, Banff, Alberta, Canada during June 26 to June 30, 1991. The theme of these symposia has been to recognize the similarities and dissimilarities of excitation-contraction coupling in skeletal, cardiac, and smooth muscle. Cross fertilization of concepts of excitation-contraction coupling in these three types of muscle has occurred since the early studies in the late fifties and early sixties on skeletal muscle. Investigators in each field meet only at specialized symposia which exclude investigators in the other fields. The purpose of the symposia has been to bring together international investigators studying excitation-contraction coupling in skeletal, cardiac, and smooth muscle so that we may learn from each other and hence provide a more global concept of excitation-contraction. The Third International Symposia has accomplished its objective as we recognize that calcium channels of the sarcolemma and the sarcoplasmic reticulum play key essential roles in excitation-contraction coupling in all three types of muscles. In skeletal muscle the recognition that E-C coupling consists of two parallel mechanisms, one dependent upon a dihydropyridine voltage-sensitive sensors coupled to calcium release from the terminal cisternae via the ryanodine sensitive channel in the foot structure of the triad.