This issue of Surgical Oncology Clinics of North America, Guest Edited by John M. Kane III, MD, is devoted to Sarcomas. Articles in this issue include: Prognostic Factors and Staging for Soft Tissue Sarcomas; Margin Status and Local Recurrence: Correlation or Causation?; Systemic Chemotherapy in the Adjuvant and Clinical Metastatic Setting; Pulmonary Metastasectomy; Regional Therapy for Advanced Extremity Sarcomas; Current Approaches to Retroperitoneal Sarcomas; Updates on the Management of Gastrointestinal Stromal Tumors (GIST); Soft Tissue Sarcoma: Immunologic Implications; Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: What is it?; Modern Surgical Therapy: Limb Salvage and the Role of Amputation; Adjuvant Radiation Therapy: and Preoperative, Postoperative, or Not at All.
Steven A. Rosenberg, MD In the past two decades significant progress has quality of life. The use of local radiation therapy has occurred, in the management of patients with mus- had a profound impact on the ability to achieve local loskeletal cancers, that has improved both the survival control. Cooperation between surgeons and radiation and the quality of life of afflicted patients. Changes in therapists often results in the tailoring of surgical p- the management of these patients have mirrored cedures to maximize the combined application of these trends in the entire field of oncology. two effective treatment modalities. Although impact on The most significant change has been improvement overall survival has not been demonstrated due to the in the surgical techniques for the resection of musculo- addition of radiation therapy, important advances in skeletal cancers based on a detailed understanding of improving the quality of life of patients receiving this the anatomic features of each particular tumor site, as combined-modality treatment have been evident. well as an appreciation of the natural biology that affects A third change impacting on the survival of patients the local spread of these tumors. The current volume of with musculoskeletal cancers has been the aggressive Musculoskeletal Cancer Surgery: Treatment of Sarcomas and resection of metastatic deposits.
This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Chandrajit P. Raut, is devoted to Sarcomas. Dr. Raut has assembled expert authors to review the following topics: Sarcoma: Histologic Subtypes and Changes in the Recent WHO Classification; Distinguishing Radiologic Characteristics of Sarcoma Histologic Subtypes; Extremity Soft Tissue Sarcoma: Tailoring Resection to Histologic Subtype; Retroperitoneal Sarcoma: Fact, Opinion, and Controversy; Breast Sarcoma; Management of Sarcoma Metastases to the Lung; Gastrointestinal Stromal Tumor; Liposarcoma: Surgical Management and Future Targeted Therapy; Myxofibrosarcoma; Malignant Peripheral Nerve Sheath Tumor; Desmoid Fibromatosis: Evolving Treatment Standards; Dermatofibrosarcoma Protuberans: Surgery v. Mohs; Radiation Therapy: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, IORT, and Brachytherapy; Chemotherapy: Does Neoadjuvant or Adjuvant Therapy Improve Outcomes?; and more!
In this issue of Surgical Oncology Clinics, guest editors Drs. Chandrajit P. Raut and Alessandro Gronchi bring their considerable expertise to the topic of Sarcoma. Top experts in the field provide articles on management of common types of sarcoma, as well as drug trials, WHO updates, and clinical trials. - Contains 15 relevant, practice-oriented topics including relevant trials update in sarcomas and GIST: what surgeons should know; management of retroperitoneal/mesenteric liposarcoma; management of solitary fibrous tumors; management of skin sarcomas (AS, LMS, DFSP, AFX); management of leiomyosarcoma; and more. - Provides in-depth clinical reviews on sarcoma, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Michael I. D'Angelica, is devoted to Management of Metastatic Liver Tumors. Dr. D'Angelica has assembled expert authors to review the following topics: Surgical management of liver metastases of colorectal cancer; Surgical management of liver metastases of breast cancer; Surgical management of liver metastases of neuroendocrine tumors; Surgical management of liver metastases of sarcoma (including GIST); Surgical management of liver metastases of gynecologic cancers; Surgical management of liver metastases of genitourinary cancers; Surgical management of liver metastases of uveal and dermal melanoma; Is there a role for locoregional therapies for non-colorectal GI malignancies?; Intra-arterial chemotherapy for liver metastases; External beam radiation for liver metastases; Isolated hepatic perfusion for liver metastases; Debate: Improvements in systemic therapies for liver metastases will soon render locoregional treatments obsolete; Debate: Improvements in systemic therapies for liver metastases will increase the role of locoregional treatments; and more!
Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.
This book aims to compile an expert text on the multidisciplinary approach to treating sarcoma at a sarcoma centre. Separate chapters and sections highlight the specialist diagnostic and therapeutic approaches employed in treating bone and soft tissue sarcoma. This comprehensive book covers sarcoma and its management across specialties. It brings together the experience of the editor at a major centre for sarcoma management in Australia along with chapter contributions from various experts on the topic. The real-life, pragmatic approach is a distillation of the evidence and intends to make much of what is written translatable. This book serves as a reference for managing this tumour type and as an indispensable guide for daily use across the spectrum of providers.
This issue of Surgical Oncology Clinics of North America, guest edited by Drs. Usman Ahmad and Sudish Murthy, is devoted to Emerging Therapies in Thoracic Malignancies. Drs. Ahmad and Murthy has assembled expert authors to review the following topics: Mediastinal Germ Cell Tumors: Updates in Diagnosis and Management; Multidisciplinary Evaluation and Management of Early Stage Esophageal Cancer; Evaluation of Risk for Thoracic Surgery; Mesothelioma: Updates in Staging and Management; Chest Wall Sarcoma: When and Who to Resect and How to Reconstruct; Management of Locally Advanced Esophageal Cancer; Locally Advanced Lung Cancer and Salvage Resections; Siewert III Adenocarcinoma: Still Searching for the Right Treatment Combination; Current Indications for Pulmonary Metastasectomy; Lung Cancer Screening; Thymic Malignancies: Updates in Treatment and Staging; Intra-operative Detection and Assessment of Lung Nodules; Targeted Therapies, Immunotherapy and T-Cell Therapy in Lung Cancer; and more!
This volume is a comprehensive guide to the diagnosis and treatment of benign and malignant tumors of the bone and soft tissues. Coverage includes: general issues in diagnosis, staging, surgery, radiation therapy, chemotherapy, and the psychological aspects of patient management. Focus is placed on benign bone tumors, malignant bone tumors, soft-tissue tumors, and carcinoma metastatic to bone. The sections on malignant bone tumors and carcinoma metastatic to bone include detailed guidelines for surgical treatment in each anatomic site. Special features include: considerations for management of malignant bone tumors in growing children; and discussions on the biology and complications of prosthetic and allograft reconstruction.
Sarcomas: Evidence-Based Diagnosisand Management is the most comprehensive clinical reference on sarcomas available to oncologists and trainees. Presenting a compilation of the current knowledge of specific soft tissue and bone sarcomas, this accessible resource on diagnosis and management is the most practical in the market. Led by the world’s foremost sarcomas experts in medical oncology, surgical oncology, radiation oncology, gynecologic oncology, orthopedic surgery, radiology, and pathology, the book addresses the general principles of each major medical discipline, provides details on each major sarcoma subtype, and presents the evidence for standard frontline, adjuvant, and novel treatment approaches such as immunotherapy, cellular therapies, and more. The book begins with general principles of diagnosis and management for each discipline in the field, covering specialties from medical oncology to radiology. Following the chapters on general principles, are chapters characterizing the most prevalent subtypes of sarcoma including their estimated incidence, common presenting symptoms, diagnostic approach, radiographic features and essential imaging, key diagnostic features, molecular characteristics, approaches to treatment, recommended follow up, the metastatic potential as well as evidence-based therapeutic approaches. Each chapter ends with a summary of caveats, clinical pearls, pitfalls, and solutions as well as a case study from the clinician’s point of view. The book ends with chapters focusing on new approaches to treatment and the development of therapeutics to combat sarcoma using immunotherapy, cellular therapy, and interventional radiology. Numerous tables and disease-based images support the text and provide key information for quick reference. Presenting detailed evidence and authoritative clinical guidance throughout, Sarcomas is a “one-stop” guide for any clinician diagnosing, treating, or managing patients suffering from these heterogenous diseases. Key Features: Provides the standards of care and evidence base for treatment of each major sarcoma subtype Covers all new treatment paradigms and FDA approvals Includes numerous quick reference tables and high-quality color images Presents over 20 practical case studies from leading clinicians in the field
