"This book makes cancer understandable to a wide audience by combining science with humor, while accurately capturing the current state of knowledge in this rapidly changing field of medicine"--
A brilliant virtuoso of violence, Richard Marcinko rose through Navy ranks to create and command one of this country's most elite and classified counterterrorist units, SEAL TEAM SIX. Now this thirty-year veteran recounts the secret missions and Special Warfare madness of his worldwide military career—and the riveting truth about the top-secret Navy SEALs. Marcinko was almost inhumanly tough, and proved it on hair-raising missions across Vietnam and a war-torn world: blowing up supply junks, charging through minefields, jumping at 19,000 feet with a chute that wouldn't open, fighting hand-to-hand in a hellhole jungle. For the Pentagon, he organized the Navy's first counterterrorist unit: the legendary SEAL TEAM SIX, which went on classified missions from Central America to the Middle East, the North Sea, Africa and beyond. Then Marcinko was tapped to create Red Cell, a dirty-dozen team of the military's most accomplished and decorated counterterrorists. Their unbelievable job was to test the defenses of the Navy's most secure facilities and installations. The result was predictable: all hell broke loose. Here is the hero who saw beyond the blood to ultimate justice—and the decorated warrior who became such a maverick that the Navy brass wanted his head on a pole, and for a time, got it. Richard Marcinko—ROGUE WARRIOR.
Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured. Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation. This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.
This new edition of Introducing Pharmacology remains an accessible and relevant introduction for nursing and healthcare students who are new to pharmacology, as well anyone looking to refresh their knowledge of the subject. Focused and engaging, the text balances accessibility with depth. Coverage of anatomy and physiology as well as pathophysiology helps to relate the subject to practical realities and makes this text stand out. It includes: Concise explanations of how drugs work in the human body. Explains the underlying physiology and pathophysiology necessary for an understanding of the action of drugs. All of the common drug groups that practitioners are likely to encounter in clinical practice. New to this edition: Additional chapter on cancer and anti-cancer drugs. New sections, including general anaesthetics, hay-fever and prescribing for special groups such as children, pregnant women and the elderly. Updated to include the latest UK prescribing guidelines. New case-studies, relating pharmacological theory to clinical practice. Inclusion of a new glossary of key terms and definitions.
Winner of the National Sporting Club's prestigious British Rugby Book of the Year Award for 2008, Ripley's World transforms and redefines the genre of the sports autobiography. In a moving and intimate memoir, Andy Ripley, England rugby icon and victorious British Lion, television Superstar and world rowing champion, reflects on a life of sporting achievement and confronts his most powerful and dangerous challenge yet - his diagnosis with prostate cancer. Told with typical candour and courage, it is an absorbing and inspirational story.
This book constitutes the refereed proceedings of the 7th International Conference on Mathematical Methods, Models, and Architectures for Computer Network Security, MMM-ACNS 2017, held in Warsaw, Poland, in August 2017. The 12 revised full papers, 13 revised short presentations, and 3 invited papers were carefully reviewed and selected from a total of 40 submissions. The papers are organized in topical sections on Critical Infrastructure Protection and Visualization; Security and Resilience of Network Systems; Adaptive Security; Anti-malware Techniques: Detection, Analysis, Prevention; Security of Emerging Technologies; Applied Cryptography; New Ideas and Paradigms for Security.
This book provides a comprehensive overview of the latest research and standardization progress towards the 5th generation (5G) of mobile communications technology and beyond. It covers a wide range of topics from 5G use cases and their requirements, to spectrum, 5G end-to-end (E2E) system architecture including core network (CN), transport network (TN) and radio access network (RAN) architecture, network slicing, security and network management. It further dives into the detailed functional design and the evaluation of different 5G concepts, and provides details on planned trials and pre-commercial deployments across the globe. While the book naturally captures the latest agreements in 3rd Generation Partnership Project (3GPP) New Radio (NR) Release 15, it goes significantly beyond this by describing the likely developments towards the final 5G system that will ultimately utilize a wide range of spectrum bands, address all envisioned 5G use cases, and meet or exceed the International Mobile Telecommunications (IMT) requirements for the year 2020 and beyond (IMT-2020). 5G System Design: Architectural and Functional Considerations and Long Term Research is based on the knowledge and consensus from 158 leading researchers and standardization experts from 54 companies or institutes around the globe, representing key mobile network operators, network vendors, academic institutions and regional bodies for 5G. Different from earlier books on 5G, it does not focus on single 5G technology components, but describes the full 5G system design from E2E architecture to detailed functional design, including details on 5G performance, implementation and roll-out.
Understanding Cancer is a brand new undergraduate textbook for students without prior training in biology that integrates an introduction to cancer medicine with descriptions of the biological processes that go wrong to cause cancer’s onset and progression. It also highlights the human side of cancer with stories of patients and loved ones touched by the disease, dealing with diagnosis, treatment, and the prospect of death as well as the broader societal aspects of cancer and its prevention. Key discoveries that have improved our understanding of cancer are presented in sidebars. In spite of this diversity, the book maintains precision and simplicity in describing what is and is not known about cancer, describing the strengths and limitations of current treatments
From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
This book completely and thoroughly covers every trick known about Subtotals in Excel. You will learn: How to get your data ready for subtotals, Adding Subtotals, Showing only the Subtotals, Sorting Subtotals, Formatting Subtotals, Subtotal Tricks, Subtotal Troubleshooting, Using the SUBTOTAL function without using the Subtotal command, using AGGREGATE, Creating Subtotals with VBA, Replacing Subtotals with Power Query.