Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. - Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers - Covers disease groups and ancillary information about techniques, resources and consequences - Follows a structured blueprint, ensuring essential chapters items are not overlooked
Gender Law and Policy, Fourth Edition, by Katharine T. Bartlett, Deborah L. Rhode, Joanna L. Grossman, Deborah L. Brake, and Frank Rudy Cooper provides the theoretical frameworks, legal cases, and policy background necessary for analyzing a broad range of gender issues in the law. It is an ideal text for undergraduate courses in Women’s Studies, Political Science, and other fields focusing on gender law and policy, including Women and the Law and Gender Law and Policy. This text features lucid introductions in each chapter that illuminate the issues significant to each topic, alternative theoretical perspectives that facilitate open-minded problem-solving, and incisive commentary by leading scholars and policymakers. Timely coverage of foundational and cutting-edge issues includes constitutional law, employment law, Title IX and education (including sports), family law, sexual harassment, sexual violence, pornography, prostitution, global trafficking, LGBT issues, and women’s sexual and reproductive health. Features of the Fourth Edition: Organized in five chapters focusing on different theoretical frameworks to enable students to grasp different conceptualizations of equality and justice. Introductory chapter with a broad overview of the theoretical frameworks, as well as the adjacent critical theories with the most relevance to the study of gender and law—intersectionality, queer theory, and masculinities studies. Includes more than 200 “Putting Theory into Practice” Problems, most based on real-life, unresolved problems, to keep a consistent, stimulating focus on the relationship between theory and practice. Coverage of latest developments in the field, including Supreme Court decisions on abortion and LGBT discrimination. Features boxed definitions of terms and explanations of the legal process that are important for understanding the cases and a glossary where students can look up unfamiliar terms and concepts. Provides timelines and charts for graphic enhancement of important information. Offers clear introductions to each chapter, subject matter, and lead case, along with reading questions, so that students can focus on the implications of the law rather than figure out the content of the law. Tailors cases to undergraduate use, almost entirely omitting procedural issues but preserving detailed facts necessary for analysis. New or enhanced coverage of the #MeToo movement, reproductive justice, campus sexual assault, trans athlete bans, and intimate partner violence. Professors and students will benefit from: Adaptation of the best-selling law school gender and law textbook for undergraduate use for courses in gender, law, and policy. Intersperses theoretical and practice materials: excerpted legal cases, statutes, and law review articles form an ongoing dialogue within the book to stimulate thought and discussion. Provides complete, up-to-date coverage of conventional “women and the law” issues, including constitutional law, employment law, affirmative action, sexual harassment, reproductive rights, domestic violence, Title IX, and poverty and race, along with analysis of cutting-edge issues relating to LGBTQ and nonbinary individuals.
"This is the colorful and dramatic biography of two of America's most controversial entrepreneurs: Moses Louis Annenberg, 'the racing wire king, ' who built his fortune in racketeering, invested it in publishing, and lost much of it in the biggest tax evasion case in United States history; and his son, Walter, launcher of TV Guide and Seventeen magazines and former ambassador to Great Britain."--Jacket.
Traditionally, cognition and emotion are seen as separate domains that are independent at best and in competition at worst. The French scientist and philosopher Blaise Pascal (1623-1662) famously said “Le coeur a ses raisons que la raison ne connaît point” (The heart has its reasons that reason does not know). Over the last century, however, psychologists and neuroscientists have increasingly appreciated their very strong reciprocal connections and interactions. Initially this was demonstrated in cognitive functions such as attention, learning and memory, and decision making. For instance, an emotional stimulus captures attention (e.g., Anderson & Phelps, 2001). Likewise, emotional stimuli are better learned and remembered than neutral ones (e.g., McGaugh, 1990) and they can provide strong incentives to bias decision making (Bechara et al., 1997). In more recent years, cognitive control has also been found to be intimately intertwined with emotion. This is consistent with an approach that considers cognitive control as an adaptive learning process (Braver & Cohen, 1999), reinforcement learning in particular (Holroyd & Coles, 2002; Verguts & Notebaert, 2009). From this perspective, cognitive control is not a cool encapsulated executive function, but instead involves rapidly calculating the value of situational, contextual, and action cues (Rushworth & Behrens, 2008) for the purpose of adapting the cognitive system toward future optimal performance. A wide array of research has shed light on cognitive control and its interactions with affect or motivation. Behaviorally, important phenomena include how people respond to difficult stimuli (e.g., incongruent stimuli, task switches), negative feedback, or errors and how this influences subsequent task processing. Neurally, an important target structure has been the anterior cingulate cortex (ACC) and its connections to traditional “emotional” (e.g., amygdala) and “cognitive” areas (e.g., (pre)motor cortex, dorsolateral prefrontal cortex). ACC seems to play a predominant role in integrating distant effects from remote cognitive and emotion systems in order to guide and optimize behavior. The current special issue focuses on the bi-directional link between emotion and cognitive control. We invite studies that investigate the influence from emotion on cognitive control, or vice versa, the influence of cognitive control on emotion. Contributions can be of different types: We welcome empirical contributions (behavioral or neuroscientific) but also computational modeling, theory, or review papers. By bringing together researchers from the traditionally separated domains, we hope to further stimulate the crosstalk between emotion and cognitive control, and thus to deepen our understanding of both.
Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on artificial intelligence (AI), its link to precision medicine (PM), and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as AI has gained significant attention during the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems have enabled the generation of large datasets, making autoimmunity an ideal target for AI and precision medicine. More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large datasets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. - Allows the readers to gain an overview on precision medicine for autoimmune diseases leveraging AI solutions - Provides background, milestone and examples of precision medicine - Outlines the paradigm shift towards precision medicine driven by value-based systems - Discusses future applications of precision medicine research using AI - Other aspects covered in the book include regulatory insights, data analytics and visualization, types of biomarkers as well as the role of the patient in precision medicine
This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.
Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. - Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics - Features chapter contributions from leaders in the field - Consolidates fundamental concepts and current practices of precision medicine in one convenient resource
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
Practitioners are increasingly adopting a personalised medicine approach to individually tailored patient care, especially disease diagnosis and treatment with the use of biomarkers. However, development and implementation of such approaches to chronic disease prevention need further investigation and concerted efforts for proper use in healthcare systems. This book provides high-quality, multidisciplinary knowledge from research in personalised medicine, specifically personalised prevention of chronic disease. It addresses different perspectives of prevention in the field, and is the outcome of a four-year work of the Personalized prevention of Chronic Disease (PRECeDI) Consortium, a multi-disciplinary and multi-professional team of experts. The Consortium jointly agreed to document and address the five aspects or domains of personalised medicine and prevention as individual chapters: Identification of biomarkers for the prevention of chronic disease Evaluation of predictive genomic applications Ethico-legal and policy issues surrounding personalised medicine Roles and responsibilities of stakeholders in informing healthy individuals on their genome: a sociotechnical analysis Identification of organisational models for the provision of predictive genomic applications The book focuses on the Consortium's recommendations that are derived from each of these domains based on up-to-date evidence and research that the authors write, follow, and systematically organise and report. Personalisation of health care is, eventually, a driver of innovation in research and healthcare systems. With this SpringerBrief on Personalised Health Care: Fostering Precision Medicine Advancements for Gaining Population Health Impact, the Consortium provides further evidence of the clinical validity and utility of personalised medicine with special emphasis on the prevention of chronic diseases. The book is a useful resource for policy makers, industry and healthcare professionals, scientists, technology-sector professionals, investors, citizens, and private companies that need proper advice to realise the potential of personalised medicine.
