An essential book to understanding whether the new miracle cure is good science or simply too good to be true American taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system -- before it's too late.
An antidote to mathematical rigor mortis, teaching how to guess answers without needing a proof or an exact calculation. In problem solving, as in street fighting, rules are for fools: do whatever works—don't just stand there! Yet we often fear an unjustified leap even though it may land us on a correct result. Traditional mathematics teaching is largely about solving exactly stated problems exactly, yet life often hands us partly defined problems needing only moderately accurate solutions. This engaging book is an antidote to the rigor mortis brought on by too much mathematical rigor, teaching us how to guess answers without needing a proof or an exact calculation. In Street-Fighting Mathematics, Sanjoy Mahajan builds, sharpens, and demonstrates tools for educated guessing and down-and-dirty, opportunistic problem solving across diverse fields of knowledge—from mathematics to management. Mahajan describes six tools: dimensional analysis, easy cases, lumping, picture proofs, successive approximation, and reasoning by analogy. Illustrating each tool with numerous examples, he carefully separates the tool—the general principle—from the particular application so that the reader can most easily grasp the tool itself to use on problems of particular interest. Street-Fighting Mathematics grew out of a short course taught by the author at MIT for students ranging from first-year undergraduates to graduate students ready for careers in physics, mathematics, management, electrical engineering, computer science, and biology. They benefited from an approach that avoided rigor and taught them how to use mathematics to solve real problems. Street-Fighting Mathematics will appear in print and online under a Creative Commons Noncommercial Share Alike license.
A postmortem X-ray of a male homicide victim reveals a bullet lodged next to his spine. That he was shot is clear. How recently? is what death investigators must determine. The answer: the absence of scar tissue surrounding the bullet proves the victim had been recently shot. And while the average person may find tattoos to be creative and aesthetic, to the trained death investigator, they can actually be the key to aiding in the eventual identification of a body. They say the dead can't speak. But in the fascinating field of forensic pathology, the deceased can tell an elaborate story, especially when death investigators know what clues to look for. The first volume in the new Forensic Pathology Atlases: Causes of Death Series, this book takes an in-depth look at the determination of the time of death, postmortem changes, and identification. In TIME OF DEATH, DECOMPOSITION AND IDENTIFICATION, you'll learn through the extensive use of photographs and discussion how estimating the time of death can rarely be accomplished with scientific accuracy. You'll learn about the numerous changes the body undergoes after death, and how positive and probable identifications are made. For death investigators, law enforcement officers, attorneys, and anyone else involved in forensic death cases, TIME OF DEATH, DECOMPOSITION AND IDENTIFICATION is a "must have" resource.
Opposing views on the merits of formal rational choice approaches as they have been applied to international security studies. Formal theories and rational choice methods have become increasingly prominent in most social sciences in the past few decades. Proponents of formal theoretical approaches argue that these methods are more scientific and sophisticated than other approaches, and that formal methods have already generated significant theoretical progress. As more and more social scientists adopt formal theoretical approaches, critics have argued that these methods are flawed and that they should not become dominant in most social-science disciplines. Rational Choice and Security Studies presents opposing views on the merits of formal rational choice approaches as they have been applied in the subfield of international security studies. This volume includes Stephen Walt's article "Rigor or Rigor Mortis? Rational Choice and Security Studies," critical replies from prominent political scientists, and Walt's rejoinder to his critics. Walt argues that formal approaches have not led to creative new theoretical explanations, that they lack empirical support, and that they have contributed little to the analysis of important contemporary security problems. In their replies, proponents of rational choice approaches emphasize that formal methods are essential for achieving theoretical consistency and precision.
Forensic Medicine encompasses all areas in which medicine and law interact. This book covers diverse aspects of forensic medicine including forensic pathology, traumatology and violent death, sudden and unexpected death, clinical forensic medicine, toxicology, traffic medicine, identification, haemogenetics and medical law. A knowledge of all these subdisciplines is necessary in order to solve routine as well as more unusual cases. Taking a comprehensive approach the book m.oves beyond a focus on forensic pathology to include clinical forensic medicine and forensic toxicology. All aspects of forensic medicine are covered to meet the specialist needs of daily casework. Aspects of routine analysis and quality control are addressed in each chapter. The book provides coverage of the latest developments in forensic molecular biology, forensic toxicology, molecular pathology and immunohistochemistry. A must-have reference for every specialist in the field this book is set to become the bench-mark for the international forensic medical community.
The fate of the human body after death is a subject that has fascinated enquirers, both in the scientific and legal realms for millennia. However, objective research into the causes and nature of human decomposition has only taken place in the last two centuries, and quantitative measurement of the process as a means of estimating the time of death has only recently been attempted. The substantial literature concerning this research has been published in numerous scientific journals since the beginning of the nineteenth century. Human Body Decomposition expands on the current literature to include the evolving research on estimating the time of death. This volume details the process of decomposition to include early period after death when the body cools to ambient temperature, and when the body begins to putrefy. This process is significant because the estimation of the time of death becomes increasingly more difficult when the body begins to putrefy.Human Body Decomposition compiles a chronological account of research into the estimation of the time since death in human bodies found decomposed in order that researchers in the subject field can concentrate their thoughts and build on what has been achieved in the past. - Provides concise details of research, over the last 200 years, of estimating the time of death in decomposed bodies. - Covers methods of research into human decomposition in the stages of body cooling to ambient temperature and the later stages of autolysis, putrefaction and skeletonisation. - Includes a detailed account of recent research and future concepts. - Concludes with an account of the difficulties which future research into human decomposition will encounter.
Muscle and Meat Biochemistry teaches the different concepts and topics under the eponymous subject. The book covers the gross and detailed composition and structure of muscles and the relationship of the nervous system with the muscular system; muscle cell differentiation and growth; proteins of the thick filament; and the molecular structure and enzymatic activity of myosin. The text also discusses the proteins found in the thin filament - actin, troponin, and myosin; skeletal muscle growth; protein metabolism; and fiber types. The book also encompasses cardiac and smooth muscle; sarcoplasmic proteins; the connective tissues - collagen, elastin, and ground substance; and the postmortem changes during conversion of muscle to meat. The text is recommended for advanced undergraduate and graduate students, as well as for scientists who would like to know more about muscle biology, muscle physiology, and meat science.
Forensic medicine covers an amazing range of different subjects and no single individual can expect to be an expert in all of them. The Oxford Handbook of Forensic Medicine provides comprehensive coverage of all areas within this complex discipline. Written for specialists and non-specialists alike, it will appeal to practising forensic scientists, as well as lawyers, police officers, and forensic science students. It shows how forensic medicine has been used in specific cases enabling the reader to apply their knowledge in real life. A detailed glossary of medical terms helps those without medical training to understand medical reports and practices. This easily-portable guide is essential reading for the busy clinical forensic doctor or nurse, and others working at the interface between medicine and law.
One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science.
Estimation of the Time Since Death remains the foremost authoritative book on scientifically calculating the estimated time of death postmortem. Building on the success of previous editions which covered the early postmortem period, this new edition also covers the later postmortem period including putrefactive changes, entomology, and postmortem r
