Reward- and aversion-related processing in the brain: translational evidence for separate and shared circuits
Reward- and aversion-related processing in the brain: translational evidence for separate and shared circuits

Author: Dave J. Hayes

Publisher: Frontiers Media SA

Published: 2016-05-18

Total Pages: 183

ISBN-13: 2889198367

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Affective brain circuits underpin our moods and emotions. Appetitive and aversive stimuli from our exteroceptive and interoceptive worlds play a key role in the activity of these circuits, but we still do not know precisely how to characterize these so-called reward-related and aversion-related systems. Moreover, we do we yet understand how they interact anatomically or functionally. The aim of the current project was to gather some translational evidence to help clarify the role of such circuits. A multi-dimensional problem in its own right, the book contains 14 works from authors exploring these questions at many levels, from the cellular to the cognitive-behavioural, and from both experimental and conceptual viewpoints. The editorial which introduces the book provides brief summaries of each perspective (Hayes, Northoff, Greenshaw, 2015). While questions of how to accurately define affect- and emotion-related concepts at the psychological level are far from answered, here we have attempted to provide some insight into the brain-based underpinnings of such processes. The near future will undoubtedly involve making new inroads and will require the joint efforts of behavioural, brain-based, and philosophical perspectives to do so.

Pleasures of the Brain
Pleasures of the Brain

Author: Morten L. Kringelbach

Publisher: Oxford University Press, USA

Published: 2010

Total Pages: 352

ISBN-13: 0195331028

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Pleasure is fundamental to well-being and the quality of life, but until recently, was barely explored by science. Current research on pleasure has brought about ground-breaking developments on several fronts, and new data on pleasure and the brain have begun to converge from many disparate fields. The time is ripe to present these important findings in a single volume, and so Morten Kringelbach and Kent Berridge have brought together the leading researchers to provides a comprehensive review of our current scientific understanding of pleasure. The authors present their latest neuroscientific research into pleasure, describing studies on the brain's role in pleasure and reward in animals and humans, including brain mechanisms, neuroimaging data, and psychological analyses, as well as how their findings have been applied to clinical problems, such as depression and other disorders of hedonic well-being. To clarify the differences between their views, the researchers also provide short answers to a set of fundamental questions about pleasure and its relation to the brain. This book is intended to serve as both a starting point for readers new to the field, and as a reference for more experienced graduate students and scientists from fields such as neuroscience, psychology, psychiatry, neurology, and neurosurgery.

The Molecular Basis of Drug Addiction
The Molecular Basis of Drug Addiction

Author: Shafiqur Rahman

Publisher: Academic Press

Published: 2016-01-28

Total Pages: 279

ISBN-13: 0128038683

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This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction. - Contains contributions from leading authorities - Informs and updates on all the latest developments in the field

Culture, Mind, and Brain
Culture, Mind, and Brain

Author: Laurence J. Kirmayer

Publisher: Cambridge University Press

Published: 2020-09-24

Total Pages: 683

ISBN-13: 1108580572

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Recent neuroscience research makes it clear that human biology is cultural biology - we develop and live our lives in socially constructed worlds that vary widely in their structure values, and institutions. This integrative volume brings together interdisciplinary perspectives from the human, social, and biological sciences to explore culture, mind, and brain interactions and their impact on personal and societal issues. Contributors provide a fresh look at emerging concepts, models, and applications of the co-constitution of culture, mind, and brain. Chapters survey the latest theoretical and methodological insights alongside the challenges in this area, and describe how these new ideas are being applied in the sciences, humanities, arts, mental health, and everyday life. Readers will gain new appreciation of the ways in which our unique biology and cultural diversity shape behavior and experience, and our ongoing adaptation to a constantly changing world.

The Pleasure Center
The Pleasure Center

Author: Morten L. Kringelbach

Publisher: Oxford University Press

Published: 2009

Total Pages: 300

ISBN-13: 0195322851

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Many people believe that pleasure and desire are obstacles to reasonable and intelligent behavior. In The Pleasure Center, Morten Kringelbach reveals that what we desire, what pleases us--in fact, our most base, animalistic tendencies--are actually very important sources of information. They motivate us for a good reason. And understanding that reason, taking that reason into account, and harnessing and directing that reason, can make us much more rational and effective people. In exploring the many facets of pleasure, desire and emotion, Kringelbach takes us through the whole spectrum of human experience, such as how emotion fuels our interest in things, allowing us to pay attention and learn. He investigates the reward systems of the brain and sheds light on some of the most interesting new discoveries about pleasure and desire. Kringelbach concludes that if we understand and accept how pleasure and desire arise in the complex interaction between the brain's activity and our own experiences, we can discover what helps us enjoy life, enabling us to make better decisions and, ultimately, lead happier lives.

Chronic Pain and Addiction
Chronic Pain and Addiction

Author: Michael R. Clark

Publisher: Karger Medical and Scientific Publishers

Published: 2011-01-01

Total Pages: 171

ISBN-13: 3805597258

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The relationship between chronic pain and addiction Patients with chronic pain understandably seek relief from their distress and discomfort, but many medications that alleviate pain are potentially addictive, and most chronic pain conditions only have a temporary response to opiate analgesic drugs. This volume reviews the fundamental topics that underlie the complex relationships of this controversial domain. The authors review behavioral models and practical methods for understanding and treating chronic pain and addiction including methods to formulate patients with complex comorbidity and screen patients with chronic pain for addictive liability. Finally, the authors describe the current findings from clinical and basic science that illuminate the role of opiates, cannabinoids and ketamine in the treatment of chronic pain. Up to date and comprehensive, this book is relevant to all professionals engaged in the care of patients with chronic pain or addiction and all others interested in these contemporary issues, particularly non-clinicians seeking clarity in the controversy over the best approach to patients with chronic pain.

The Spontaneous Brain
The Spontaneous Brain

Author: Georg Northoff

Publisher: MIT Press

Published: 2024-08-06

Total Pages: 533

ISBN-13: 0262552825

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An argument for a Copernican revolution in our consideration of mental features—a shift in which the world-brain problem supersedes the mind-body problem. Philosophers have long debated the mind-body problem—whether to attribute such mental features as consciousness to mind or to body. Meanwhile, neuroscientists search for empirical answers, seeking neural correlates for consciousness, self, and free will. In this book, Georg Northoff does not propose new solutions to the mind-body problem; instead, he questions the problem itself, arguing that it is an empirically, ontologically, and conceptually implausible way to address the existence and reality of mental features. We are better off, he contends, by addressing consciousness and other mental features in terms of the relationship between world and brain; philosophers should consider the world-brain problem rather than the mind-body problem. This calls for a Copernican shift in vantage point—from within the mind or brain to beyond the brain—in our consideration of mental features. Northoff, a neuroscientist, psychiatrist, and philosopher, explains that empirical evidence suggests that the brain's spontaneous activity and its spatiotemporal structure are central to aligning and integrating the brain within the world. This spatiotemporal structure allows the brain to extend beyond itself into body and world, creating the “world-brain relation” that is central to mental features. Northoff makes his argument in empirical, ontological, and epistemic-methodological terms. He discusses current models of the brain and applies these models to recent data on neuronal features underlying consciousness and proposes the world-brain relation as the ontological predisposition for consciousness.

Impulsivity and Compulsivity
Impulsivity and Compulsivity

Author: John M. Oldham

Publisher: American Psychiatric Pub

Published: 1996

Total Pages: 314

ISBN-13: 9780880486767

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Traditionally, impulsive and compulsive behaviors have been categorized as fundamentally distinct. However, patients often exhibit both of these behaviors. This common comorbidity has sparked renewed interest in the factors contributing to the disorders in which these behaviors are prominent. Impulsivity and Compulsivity applies a provocative spectrum model to this psychopathology. The spectrum model is consistent with a dimensional model for psychopathology and considers the dynamic interaction of biopsychosocial forces in the development of impulsive and compulsive disorders. In this important work on impulsive/compulsive psychopathology, leading researchers and clinicians share their expertise on the phenomenological, biological, psychodynamic, and treatment aspects of these disorders. Differential diagnosis, comorbidity of the impulsive-compulsive spectrum of disorders, and assessment by the seven-factor model of temperament and character are discussed. Chapters are also dedicated to the antianxiety function of impulsivity and compulsivity, defense mechanisms in impulsive disorders versus obsessive-compulsive disorders, and the unique aspects of psychotherapy with impulsive and compulsive patients. Clinical researchers and clinicians will be enlightened by this exceptional work. The information provided is supplemented with clinical vignettes, and the final chapter provides a synthetic summary that offers a unified, dynamic approach to impulsive and compulsive behavior.

Drugs, Addiction, and the Brain
Drugs, Addiction, and the Brain

Author: George F. Koob

Publisher: Academic Press

Published: 2014-07-12

Total Pages: 351

ISBN-13: 0123869595

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Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain. - Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle - Actual data figures from original sources illustrating key concepts and findings - Introduction to basic neuropharmacology terms and concepts - Introduction to numerous animal models used to study diverse aspects of drug use. - Thorough review of extant work on the neurobiology of addiction

Salience Network of the Human Brain
Salience Network of the Human Brain

Author: Lucina Q. Uddin

Publisher: Academic Press

Published: 2016-08-24

Total Pages: 48

ISBN-13: 0128045949

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Salience Network of the Human Brain focuses on the multiple sources of stimuli that compete for our attention, providing interesting discussions on how the relative salience—importance or prominence—of each of these inputs determines which ones we choose to focus on for more in-depth processing. The salience network is a collection of regions of the brain that select which stimuli are deserving of our attention. The network has key nodes in the insular cortex and is critical for detecting behaviorally relevant stimuli and for coordinating the brain's neural resources in response to these stimuli. The insular cortex is a complex and multipurpose structure that plays a role in numerous cognitive functions related to perception, emotion, and interpersonal experience—and the failure of this network to function properly can lead to numerous neuropsychiatric disorders, including autism spectrum disorder, psychosis, and dementia. - Presents the only publication available that summarizes our understanding of the salience network in one resource - Authored by a leading research on this important aspect of attention - Focuses on the multiple sources of stimuli that compete for our attention, providing interesting discussions on how the relative salience—importance or prominence—of each of these inputs determines which ones we choose to focus on for more in-depth processing