Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition

Revisiting Seed and Soil: A New Approach to Target Hibernating Dormant Tumor Cells, 2nd edition

Author: Dalit Barkan

Publisher: Frontiers Media SA

Published: 2023-03-07

Total Pages: 158

ISBN-13: 2832512542

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Metastasis is the major cause of mortality in cancer patients. Metastases can be present at the time of diagnosis or can occur years or decades after the removal of the primary tumor and treatment. This long latency in the manifestation of recurrent metastatic disease is explained clinically by the persistence of quiescent tumor cells that disseminated early in the course of the disease from the primary tumor to select distant organs. These residing disseminated tumor cells (DTCs) at distant organs lay dormant and asymptomatic until reawakened to form overt metastases. Importantly, the quiescent nature of these “hibernating” DTCs facilitates their resistance to conventional therapies that target actively dividing tumor cells. Therefore, unraveling the biology of dormancy and reactivation of the residing DTCs to life-threatening lesions is of utmost importance in order to develop new therapeutic strategies to prevent the recurrent metastatic disease from ever emerging or to better treat these recurrent cancers. The mechanisms underlying the biology of tumor dormancy and their reactivation to overt metastases are just beginning to emerge thanks to a growing appreciation of the potentially chronic nature of some cancers and the development of experimental model systems for their study. In this Research Topic, we will follow the journey of circulating tumor cells (CTCs) dispatching from the primary site until their successful lodging into a new and foreign site to become DTCs. We will explore the intrinsic mechanisms along with microenvironmental cues and niches that they encounter during their journey that may dictate their fate.


Medical and Veterinary Entomology

Medical and Veterinary Entomology

Author: Gary R. Mullen

Publisher: Academic Press

Published: 2009-04-22

Total Pages: 646

ISBN-13: 0080919693

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Medical and Veterinary Entomology, Second Edition, has been fully updated and revised to provide the latest information on developments in entomology relating to public health and veterinary importance. Each chapter is structured with the student in mind, organized by the major headings of Taxonomy, Morphology, Life History, Behavior and Ecology, Public Health and Veterinary Importance, and Prevention and Control. This second edition includes separate chapters devoted to each of the taxonomic groups of insects and arachnids of medical or veterinary concern, including spiders, scorpions, mites, and ticks. Internationally recognized editors Mullen and Durden include extensive coverage of both medical and veterinary entomological importance. This book is designed for teaching and research faculty in medical and veterinary schools that provide a course in vector borne diseases and medical entomology; parasitologists, entomologists, and government scientists responsible for oversight and monitoring of insect vector borne diseases; and medical and veterinary school libraries and libraries at institutions with strong programs in entomology. Follows in the tradition of Herm's Medical and Veterinary Entomology The latest information on developments in entomology relating to public health and veterinary importance Two separate indexes for enhanced searchability: Taxonomic and Subject New to this edition: Three new chapters Morphological Adaptations of Parasitic Arthropods Forensic Entomology Molecular Tools in Medical and Veterinary Entomology 1700 word glossary Appendix of Arthropod-Related Viruses of Medical-Veterinary Importance Numerous new full-color images, illustrations and maps throughout


Intermountain Alfalfa Management

Intermountain Alfalfa Management

Author: Steve B. Orloff

Publisher: UCANR Publications

Published: 1997-06-01

Total Pages: 152

ISBN-13: 9781879906242

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This comprehensive guide for western alfalfa growers brings together the most current information and recommendations in nearly all areas of alfalfa management, including stand establishment, fertilization, irrigation, pest management, and harvesting


Edible Insects

Edible Insects

Author: Arnold van Huis

Publisher: Bright Sparks

Published: 2013

Total Pages: 0

ISBN-13: 9789251075951

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Edible insects have always been a part of human diets, but in some societies there remains a degree of disdain and disgust for their consumption. Although the majority of consumed insects are gathered in forest habitats, mass-rearing systems are being developed in many countries. Insects offer a significant opportunity to merge traditional knowledge and modern science to improve human food security worldwide. This publication describes the contribution of insects to food security and examines future prospects for raising insects at a commercial scale to improve food and feed production, diversify diets, and support livelihoods in both developing and developed countries. It shows the many traditional and potential new uses of insects for direct human consumption and the opportunities for and constraints to farming them for food and feed. It examines the body of research on issues such as insect nutrition and food safety, the use of insects as animal feed, and the processing and preservation of insects and their products. It highlights the need to develop a regulatory framework to govern the use of insects for food security. And it presents case studies and examples from around the world. Edible insects are a promising alternative to the conventional production of meat, either for direct human consumption or for indirect use as feedstock. To fully realise this potential, much work needs to be done by a wide range of stakeholders. This publication will boost awareness of the many valuable roles that insects play in sustaining nature and human life, and it will stimulate debate on the expansion of the use of insects as food and feed.


Insect Diapause

Insect Diapause

Author: David L. Denlinger

Publisher: Cambridge University Press

Published: 2022-02-03

Total Pages: 465

ISBN-13: 1108755186

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Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation of seasonal changes and enactment of mechanisms for bringing development to a halt and then reinitiating it when the inimical season is past. The dormant state of diapause serves to bridge the unfavourable seasons, and its timing provides a powerful mechanism for synchronizing insect development. This book explores how seasonal signals are monitored and used by insects to enact specific molecular pathways that generate the diapause phenotype. The broad perspective offered here scales from the ecological to the molecular and thus provides a comprehensive view of this exciting and vibrant research field, offering insights on topics ranging from pest management, evolution, speciation, climate change and disease transmission, to human health, as well as analogies with other forms of invertebrate dormancy and mammalian hibernation.


The Potato Crop

The Potato Crop

Author: Hugo Campos

Publisher: Springer Nature

Published: 2019-12-03

Total Pages: 524

ISBN-13: 3030286835

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This book is open access under a CC BY 4.0 license. This book provides a fresh, updated and science-based perspective on the current status and prospects of the diverse array of topics related to the potato, and was written by distinguished scientists with hands-on global experience in research aspects related to potato. The potato is the third most important global food crop in terms of consumption. Being the only vegetatively propagated species among the world’s main five staple crops creates both issues and opportunities for the potato: on the one hand, this constrains the speed of its geographic expansion and its options for international commercialization and distribution when compared with commodity crops such as maize, wheat or rice. On the other, it provides an effective insulation against speculation and unforeseen spikes in commodity prices, since the potato does not represent a good traded on global markets. These two factors highlight the underappreciated and underrated role of the potato as a dependable nutrition security crop, one that can mitigate turmoil in world food supply and demand and political instability in some developing countries. Increasingly, the global role of the potato has expanded from a profitable crop in developing countries to a crop providing income and nutrition security in developing ones. This book will appeal to academics and students of crop sciences, but also policy makers and other stakeholders involved in the potato and its contribution to humankind’s food security.


Bio-Inspired Innovation and National Security

Bio-Inspired Innovation and National Security

Author: National Defense University

Publisher: NDU Press

Published: 2010-10

Total Pages: 356

ISBN-13: 1780390408

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Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.


Staying with the Trouble

Staying with the Trouble

Author: Donna J. Haraway

Publisher: Duke University Press

Published: 2016-08-25

Total Pages: 228

ISBN-13: 0822373785

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In the midst of spiraling ecological devastation, multispecies feminist theorist Donna J. Haraway offers provocative new ways to reconfigure our relations to the earth and all its inhabitants. She eschews referring to our current epoch as the Anthropocene, preferring to conceptualize it as what she calls the Chthulucene, as it more aptly and fully describes our epoch as one in which the human and nonhuman are inextricably linked in tentacular practices. The Chthulucene, Haraway explains, requires sym-poiesis, or making-with, rather than auto-poiesis, or self-making. Learning to stay with the trouble of living and dying together on a damaged earth will prove more conducive to the kind of thinking that would provide the means to building more livable futures. Theoretically and methodologically driven by the signifier SF—string figures, science fact, science fiction, speculative feminism, speculative fabulation, so far—Staying with the Trouble further cements Haraway's reputation as one of the most daring and original thinkers of our time.


Beta maritima

Beta maritima

Author: enrico biancardi

Publisher: Springer Science & Business Media

Published: 2011-12-07

Total Pages: 305

ISBN-13: 1461408415

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Along the undisturbed shores, especially of the Mediterranean Sea and the European North Atlantic Ocean, is a quite widespread plant called Beta maritima by botanists, or more commonly sea beet. Nothing, for the inexperienced observer's eye, distinguishes it from surrounding wild vegetation. Despite its inconspicuous and nearly invisible flowers, the plant has had and will have invaluable economic and scientific importance. Indeed, according to Linnè, it is considered "the progenitor of the beet crops possibly born from Beta maritima in some foreign country". Recent molecular research confirmed this lineage. Selection applied after domestication has created many cultivated types with different destinations. The wild plant always has been harvested and used both for food and as a medicinal herb. Sea beet crosses easily with the cultivated types. This facilitates the transmission of genetic traits lost during domestication, which selection processes aimed only at features immediately useful to farmers and consumers may have depleted. Indeed, as with several crop wild relatives, Beta maritima has been successfully used to improve cultivated beet’s genetic resistances against many diseases and pests. In fact, sugar beet cultivation currently would be impossible in many countries without the recovery of traits preserved in the wild germplasm. Dr. Enrico Biancardi graduated from Bologna University. From 1977 until 2009, he was involved in sugar beet breeding activity by the Istituto Sperimentale per le Colture Industriali (ISCI) formerly Stazione Sperimentale di Bieticoltura (Rovigo, Italy), where he released rhizomania and cercospora resistant germplasm and collected seeds of Mediterranean sea beet populations as a genetic resource for breeding and ex situ conservation. Retired since 2009, he still collaborates with several working breeders, in particular, at the USDA Agricultural Research Stations, at the Chinese Academy of Agricultural Science (CAAS), and at the Athens University (AUA). He has edited books, books chapters and authored more than 150 papers. Dr. Lee Panella is a plant breeder and geneticist with the USDA-ARS at Fort Collins, Colorado. He earned his B.S. in Crop and Soil Science from Michigan State University, an M.S. in Plant Breeding from Texas A&M University, and a Ph.D. in genetics from the University of California at Davis. His research focus is developing disease resistant germplasm using sugar beet wild relatives. He is chairman of the USDA-ARS Sugar Beet Crop Germplasm Committee and has collected and worked extensively with sea beet. Dr. Robert T. Lewellen was raised on a ranch in Eastern Oregon and obtained a B.S. in Crop Science from Oregon State University followed by a Ph.D. from Montana State University in Genetics. From 1966 to 2008 he was a research geneticist for the USDA-ARS at Salinas, California, where he studied the genetics of sugar beet and as a plant breeder, often used sea beet as a genetic source to produce many pest and disease resistant sugar beet germplasm and parental lines, while authoring more than 100 publications.