Summary of the Workshop on Information Needs to Address Childrens Cancer Risk
Summary of the Workshop on Information Needs to Address Childrens Cancer Risk

Author: Barry Leonard

Publisher:

Published: 2000-11-01

Total Pages: 190

ISBN-13: 9780756728649

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Report of a workshop held March 30-31, 2000. It focused on a discussion of children's cancer risk (CCR) assessment & related data needs to address issues that were raised during public review of the Agency's 1999 Draft Revised Guidelines for Carcinogen Risk. These issues include: characterizing the ideal data set to address CCR; & proposed approaches to using available data in the absence of ideal data set. The Workshop focused on four topic areas: Current & Proposed Approaches to Assessing CCR; Enhanced Use of Test Data Related to CCR; Future Directions for Toxicological Testing to Address CCR; & Epidemiological/Molecular Epidemiology Information to Address CCR. Charts & tables.

Science and Decisions
Science and Decisions

Author: National Research Council

Publisher: National Academies Press

Published: 2009-03-24

Total Pages: 422

ISBN-13: 0309120462

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Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Issues in Risk Assessment
Issues in Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 1993-02-01

Total Pages: 375

ISBN-13: 0309047862

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The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.