Functional Metabolism
Functional Metabolism

Author: Kenneth B. Storey

Publisher: John Wiley & Sons

Published: 2005-02-25

Total Pages: 640

ISBN-13: 0471675571

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Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Prokaryotic Metabolism and Physiology
Prokaryotic Metabolism and Physiology

Author: Byung Hong Kim

Publisher: Cambridge University Press

Published: 2019-05-16

Total Pages: 509

ISBN-13: 1107171733

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Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.

Cellular Energy Metabolism and Its Regulation
Cellular Energy Metabolism and Its Regulation

Author: Daniel E. Atkinson

Publisher:

Published: 1977

Total Pages: 320

ISBN-13:

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Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book dea ...

Neural Regulation of Metabolism
Neural Regulation of Metabolism

Author: Qi Wu

Publisher: Springer

Published: 2018-11-02

Total Pages: 240

ISBN-13: 9811312869

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This book systemically describes the mechanisms underlying the neural regulation of metabolism. Metabolic diseases, including obesity and its associated conditions, currently affect more than 500 million people worldwide. Recent research has shown that the neural regulation of metabolism is a central mechanism that controls metabolic status physiologically and pathophysiologically. The book first introduces the latest studies on the neural and cellular mechanisms of hypothalamic neurons, hypothalamic glial cells, neural circuitries, cellular signaling pathways, and synaptic plasticity in the control of appetite, body weight, feeding-related behaviors and metabolic disorders. It then summarizes the humoral mechanisms by which critical adipocyte-derived hormones and lipoprotein lipase regulate lipid and glucose metabolism, and examines the role of the hypothalamus-sympathetic nerve, a critical nerve pathway from CNS to peripheral nervous system (PNS), in the regulation of metabolism in multiple tissues/organs. Furthermore, the book discusses the functions of adipose tissue in energy metabolism. Lastly, it explores dietary interventions to treat neural diseases and some of the emerging technologies used to study the neural regulation of metabolism. Presenting cutting-edge developments in the neural regulation of metabolism, the book is a valuable reference resource for graduate students and researchers in the field of neuroscience and metabolism.

Bacterial Physiology and Metabolism
Bacterial Physiology and Metabolism

Author: Byung Hong Kim

Publisher: Cambridge University Press

Published: 2008-02-21

Total Pages: 934

ISBN-13: 113946762X

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Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.

Advanced Nutrition and Regulation of Metabolism
Advanced Nutrition and Regulation of Metabolism

Author: Kevin Schalinske

Publisher: Cognella Academic Publishing

Published: 2016-12-31

Total Pages: 212

ISBN-13: 9781516514687

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While written from a nutritional sciences perspective, Advanced Nutrition and Regulation of Metabolism is a reference source that emphasizes regulation of proteins and gene expression. The focus is on the function of nutrients, how function relates to deficiency and its symptoms, how both of these relate to assessment, and how this is achieved during the fed-fasted cycle. After reviewing cell biology and basic biological concepts, the book discusses digestion and absorption, carbohydrates, lipids, proteins, water-soluble vitamins, fat-soluble vitamins, and minerals. Students learn how these are all structured and absorbed, become familiar with the nomenclature, and study their impact on metabolism, as well as other essential biological functions. Each chapter includes specific objectives and outcomes to guide student learning, reflection, discussion, comprehension questions, and an application opportunity. Designed for students who are already familiar with introductory and intermediate nutritional sciences, Advanced Nutrition and Regulation of Metabolism assumes that readers have a background in cell biology, biochemistry, and physiology. The book is well-suited to advanced nutritional sciences courses, as well as some classes in animal science, kinesiology, genetics, and biochemistry. Kevin L. Schalinske earned his Ph.D. in nutritional sciences at the University of Wisconsin, where he also completed a post-doctoral fellowship. Dr. Schalinske is now a professor in the Department of Food Science and Human Nutrition at Iowa State University. His research interests include the impact of nutritional and hormonal factors on folate and methyl group metabolism, particularly as they impact health and disease. He has received funding from numerous sources including the National Institutes of Health, the American Diabetes Association, and the American Heart Association. Dr. Schalinske also serves as an associate editor for The Journal of Nutrition.

Metabolic Engineering
Metabolic Engineering

Author: Jens Nielsen

Publisher: Springer

Published: 2003-07-03

Total Pages: 193

ISBN-13: 3540453008

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Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Neuron Signaling in Metabolic Regulation
Neuron Signaling in Metabolic Regulation

Author: Qingchun Tong

Publisher: CRC Press

Published: 2021-06-07

Total Pages: 330

ISBN-13: 100036691X

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This book focuses on neuron signaling in the regulation of metabolism and body weight, and especially on methods used in these studies. Obesity and related metabolic syndromes have reached epidemic status, but still are no effective strategies for prevention and treatment. Body weight homeostasis is maintained by balanced food intake and energy expenditure, both of which are under the control of brain neurons. In the recent years, significant progress has been made in identifying specific neurons, neural pathways, and non-neuron cells in feeding regulation, as well as in delineating autonomic nervous systems targeting peripheral metabolic tissues in the regulation of energy expenditure and metabolism. This book reviews recent progress on important neuron signaling for body weight and metabolic regulation and the state-of-the-art methods that has been applied in this field, ranging from animal models with neuron-specific manipulations, pharmacology, optogenetics, in vivo Ca2+ imaging, and viral tracing. Readers will be exposed to latest research frontiers on neuron regulation of metabolism. Key Features Explores the role signaling between neurons plays with respect to metabolism Documents how neurotransmitters affect the regulation of feeding Describes various methods and technologies used to study the neuronal control of metabolism Includes contributions from an international team of leading researchers. Related Titles Lim, W. & B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Feltz, A. Physiology of Neurons (ISBN 978-0-8153-4600-5) Zempleni, J. & K. Dakshinamurti, eds. Nutrients and Cell Signaling (ISBN 978-0367-39307-6)

Human Protein Metabolism
Human Protein Metabolism

Author: Stephen Welle

Publisher: Springer Science & Business Media

Published: 1999-07-30

Total Pages: 306

ISBN-13: 9780387987507

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A succinct review of hundreds of studies on the regulation of protein mass and protein turnover in the human body. The book summarizes the biochemistry of protein synthesis and breakdown, and explains the methods that are used to examine protein metabolism in humans, together with their limitations. Chapters review the effects of nutrition, hormones, metabolic substrates, and physical activity, while various topics of clinical interest include cancer, diabetes, tissue injury, pregnancy, renal disease, muscular dystrophies, and other conditions. Normal values are presented for turnover of proteins in the whole body and individual organs, and for turnover of many individual proteins. This is thus a valuable resource for physiologists, nutritionists, and clinicians interested in the regulation of body protein stores in health and disease. For scientists primarily interested in the basic aspects of protein metabolism, it shows how the basic knowledge is being applied to the study of humans.

Bacterial Cellular Metabolic Systems
Bacterial Cellular Metabolic Systems

Author: K. Shimizu

Publisher: Elsevier

Published: 2013-03-26

Total Pages: 497

ISBN-13: 1908818204

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The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. - Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment - Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments - Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system