Redox Signaling and Biomarkers in Ageing
Redox Signaling and Biomarkers in Ageing

Author: Ufuk Çakatay

Publisher: Springer Nature

Published: 2021-12-02

Total Pages: 447

ISBN-13: 3030849651

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This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

Methods in Redox Signaling
Methods in Redox Signaling

Author: Dipak Kumar Das

Publisher:

Published: 2010

Total Pages: 0

ISBN-13: 9781934854068

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Methods in Redox Signaling is the first and only comprehensive handbook on the experimental methods used to study redox signaling. Formerly recognized as destructive mechanisms, reactive oxygen species (ROS) have now been recognized as saviors by protecting the cells through redox signaling. This evolving science involves the pathobiology of various disease processes including cancer, cardiovascular diseases, wound healing, and many other degenerative diseases. Although the concept of reactive oxygen species has been known to some for decades, their potential role in the biological system has only been recognized in recent years. With the identification of these new mechanisms and their potential, the exploration in this area is expanding rapidly and the scientific articles are pouring in. Being relatively young, a vast majority of the mechanisms of redox signaling, especially those related to disease processes still remain unknown. Methods in Redox Signaling provides a valuable tool for the growing number of scientists engaging in the research and investigation involving redox regulation of degenerative diseases.

Redox Signaling and Regulation in Biology and Medicine
Redox Signaling and Regulation in Biology and Medicine

Author: Claus Jacob

Publisher: John Wiley & Sons

Published: 2009-05-06

Total Pages: 514

ISBN-13: 3527627596

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This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

Oxidative Stress and Redox Regulation
Oxidative Stress and Redox Regulation

Author: Ursula Jakob

Publisher: Springer Science & Business Media

Published: 2013-03-15

Total Pages: 488

ISBN-13: 9400757875

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Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.

Oxidative Stress and Redox Signalling in Parkinson’s Disease
Oxidative Stress and Redox Signalling in Parkinson’s Disease

Author: Rodrigo Franco

Publisher: Royal Society of Chemistry

Published: 2017-07-25

Total Pages: 537

ISBN-13: 1782621881

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Parkinson's Disease is the second most common neurodegenerative disorder affecting millions of people worldwide. In order to find neuroprotective strategies, a clear understanding of the mechanisms involved in the dopaminergic death of cells that progresses the disease is needed. Oxidative stress can be defined as an imbalance between the production of reactive species and the ability to detoxify them and their intermediates or by-products. Oxidative damage to lipids, proteins, and DNA has been detected in autopsies from individuals with Parkinson’s Disease and so links can be made between oxidative stress and Parkinson’s Disease pathogenesis. This book provides a thorough review of the mechanisms by which oxidative stress and redox signalling mediate Parkinson’s Disease. Opening chapters bring readers up to speed on basic knowledge regarding oxidative stress and redox signalling, Parkinson’s Disease, and neurodegeneration before the latest advances in this field are explored in detail. Topics covered in the following chapters include the role of mitochondria, dopamine metabolism, metal homeostasis, inflammation, DNA-damage and thiol-signalling. The role of genetics and gene-environment interactions are also explored before final chapters discuss the identification of potential biomarkers for diagnosis and disease progression and the future of redox/antioxidant based therapeutics. Written by recognized experts in the field, this book will be a valuable source of information for postgraduate students and academics, clinicians, toxicologists and risk assessment groups. Importantly, it presents the current research that might later lead to redox or antioxidant – based therapeutics for Parkinson’s disease.

Platelets in Cardiovascular Disease
Platelets in Cardiovascular Disease

Author: Deepak L. Bhatt

Publisher: Imperial College Press

Published: 2008

Total Pages: 235

ISBN-13: 1860948529

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Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine. Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease. Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful. Sample Chapter(s). Chapter 1: Platelet Biology the Role of Platelets in Hemostasis, Thrombosis and Inflammation (274 KB). Contents: Platelet Biology: The Role of Platelets in Hemostasis, Thrombosis and Inflammation (R C Becker); Thromboxane Antagonists (B R Dulin & S R Steinhubl); Glycoprotein IIb/IIIa Inhibitors (S J Lehman et al.); ADP Receptor Antagonists (J Karha & C P Cannon); Monitoring Antiplatelet Therapy (P Harrison & A D Michelson); Platelet Genomics (B K Jefferson et al.); Future Strategies for the Development of Antiplatelet Drugs (R A Harrington). Readership: Physicians: cardiologists, vascular medicine specialists, hematologists; physicians in training: fellows, residents, interns; pharmacists; pharmaceutical industry: scientists, sales representatives.

Redox Homeostasis in Plants
Redox Homeostasis in Plants

Author: Sanjib Kumar Panda

Publisher: Springer

Published: 2019-04-23

Total Pages: 203

ISBN-13: 331995315X

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This book summarizes the latest research results on the role of reactive oxygen species (ROS) in plants, particularly in many abiotic stresses, and their regulation. Redox homeostasis refers to maintaining a balance of oxidised and reduced state of biomolecules in a biological system for all-round sustenance. In a living system, redox reactions contribute to the generation of reactive oxygen species (ROS), which act as signalling molecules for developmental as well as stress-response processes in plants. It is presumed that, being sessile and an aerobe requiring oxygen for mitochondrial energy production, as well as producing oxygen during photosynthesis, the redox homeostasis process is more complex and regulated in plants than in animals. Any imbalance in the homeostasis is mainly compensated for by the production of various ROS molecules, which, though they can cause severe oxidative damage in excess, can also ideally act as signalling molecules.

Cellular Implications Of Redox Signaling
Cellular Implications Of Redox Signaling

Author: Avihai Danon

Publisher: World Scientific

Published: 2003-07-30

Total Pages: 441

ISBN-13: 1783261153

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Redox regulation, like phosphorylation, is a covalent regulatory system that controls many of the normal cellular functions of all living cells and organisms. In addition, it controls how cells respond to stress involving oxidants and free radicals, which underlie many degenerative diseases. This area is undergoing a transition from general knowledge to specific description of the components and mechanisms involved.This invaluable book provides a timely basic description of a field whose relevance to cell biology and degenerative diseases is of the utmost importance. It describes the state of the art, lays the foundations for understanding the reactions involved, and presents the prospects for future developments. It can serve as a basic text for any undergraduate or graduate course that deals with redox regulation, oxidative stress and free radicals under normal and pathological conditions in bacterial, plant and animal cells.

Endothelium and Cardiovascular Diseases
Endothelium and Cardiovascular Diseases

Author: Protasio L. Da Luz

Publisher: Academic Press

Published: 2018-02-03

Total Pages: 760

ISBN-13: 0128125519

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Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. - Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information - Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress - Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes