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Author: Angela Mastronuzzi
Publisher: Frontiers Media SA
Published: 2021-05-03
Total Pages: 123
ISBN-13: 2889667146
DOWNLOAD EBOOKWe would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.
Author: Nathaniel H. Robin
Publisher: Elsevier Health Sciences
Published: 2017-08-22
Total Pages: 135
ISBN-13: 0323495966
DOWNLOAD EBOOKGet a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. - Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counsellors - Highlights examples of syndromes that present in childhood and increase susceptibility to cancer - Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer - Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples - Consolidates today's available information and guidance in this timely area into one convenient resource - Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. - Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. - Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. - Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. - Consolidates today's available information and guidance in this timely area into one convenient resource.
Author: Presidential Commission for the Study of Bioethical Issues
Publisher: CreateSpace
Published: 2015-03-11
Total Pages: 156
ISBN-13: 9781508807643
DOWNLOAD EBOOKAnticipate and Communicate is the Bioethics Commission's sixth major report. In this report the Bioethics Commission offers specific recommendations for the management of incidental and secondary findings in clinical, research and direct-to-consumer settings. Emerging medical technologies, changing cost structures, and evolving medical practice make the likelihood of discovering incidental and secondary findings across contexts a growing certainty. Such findings can be lifesaving, but also can lead to uncertainty and distress if they are unexpected or identify conditions for which no effective treatment is available.
Author: Katrin Scheinemann
Publisher: Springer
Published: 2015-03-26
Total Pages: 322
ISBN-13: 149391541X
DOWNLOAD EBOOK“The editors...have done an outstanding job of presenting...complex information in a lucid manner – this book is a must-read for the global community of aspiring students and neuro-oncology practitioners.” Amar Gajjar, MD in the Foreword This is a succinct introduction to pediatric neuro-oncology. It summarizes the key advances in molecular biology that have helped transform this rapidly evolving field and provides up-to-date coverage of major and emerging treatment modalities as well as supportive care. Separate chapters present each kind of pediatric brain cancer and its diagnosis and treatment. As more children survive brain cancer, the importance of quality of life issues and helping survivors to cope with the neuropsychological impact and long-term effects of current therapies has come into sharper focus; these topics are also addressed in the book, as are palliative care and pediatric neuro-oncology in countries with limited resources. The book is aimed at trainees and practitioners who seek an up-to-date text in pediatric neuro-oncology that is both comprehensive and concise.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
Published: 2021-09-09
Total Pages:
ISBN-13: 9780309683494
DOWNLOAD EBOOKSince the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Author: Hans D. Ochs
Publisher:
Published: 2007
Total Pages: 745
ISBN-13: 019514774X
DOWNLOAD EBOOKThe second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Author: Rosalind A. Eeles
Publisher: John Wiley & Sons
Published: 2018-08-15
Total Pages: 514
ISBN-13: 1118991060
DOWNLOAD EBOOKWinner of the Council Chair's Choice Award at the 2019 British Medical Association Awards. Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques
Author: B.A. Ponder
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 222
ISBN-13: 9401106770
DOWNLOAD EBOOKIt has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Author: Stephan D. Voss
Publisher: Springer
Published: 2019-04-08
Total Pages: 408
ISBN-13: 9783030037765
DOWNLOAD EBOOKThis book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.
Author: Graham Dellaire
Publisher: Academic Press
Published: 2013-11-21
Total Pages: 511
ISBN-13: 0123972744
DOWNLOAD EBOOKCancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. - Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. - Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.
