In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalylchloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The result is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound - including the safety phosgenation.
The most complete resource in functional group chemistry Patai's Chemistry of Functional Groups is one of chemistry's landmark book series in organic chemistry. An indispensible resource for the organic chemist, this is the most comprehensive reference available in functional group chemistry. Founded in 1964 by the late Professor Saul Patai, the aim of Patai's Chemistry of Functional Groups is to cover all the aspects of the chemistry of an important functional group in each volume, with the emphasis not only on the functional group but on the whole molecule.
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
The first book in the PATAI Series was published in 1964 and the Series will celebrate its 50th Anniversary in 2014. This "Golden Jubilee" is accompanied by the publication of the first volume on the chemistry of organogold. In the history of the PATAI Series there was, so far, no volume dedicated to gold alone. In 1999 we published a volume on The Chemistry of Gold and Silver Compounds. Since then a lot of new chemistry using gold has been developed and it is timely to focus a volume on methods and applications of organogold compounds in organic synthesis, reflecting the enormous progress which has been made in the use of gold compounds as reagents and catalysts. A second area of great importance covered in the book is the use of gold surfaces in the synthesis of peptides, proteins and other natural products. A whole range of applications in the area of biochemistry has resulted from these developments. A third area of interest is the synthesis and engineering of nanostructures, where organogold chemistry has opened the door for a wide range of methods and applications in the field of nanoscience and materials science. As with all new volumes, the chapters are first published online in Patai's Chemistry of Functional Groups. Once a volume is completed online, it is then published in print format. The printed book offers the traditional quality of the Patai Book Series, complete with an extensive index.
Volume 4 focuses on additions and the resulting substitutions at carbon-carbon &pgr;-bonds. Part 1 includes processes generally considered as simple polar reactions, reactive electrophiles and nucleophiles adding to alkenes and alkynes. A major topic is Michael-type addition to electron deficient &pgr;-bonds, featured in the first six chapters. In part 2 are collected the four general processes leading to nucleophilic aromatic substitution, including radical chain processes and transition metal activation through to &pgr;-complexation. Metal-activated addition (generally by nucleophiles) to alkenes and polyenes is presented in part 3, including allylic alkylation catalyzed by palladium. The coverage of nonpolar additions in part 4 includes radical additions, organometal addition (Heck reaction), carbene addition, and 1,3-dipolar cycloadditions.
The first volume of The Chemistry of the Hydrazo, Azo and Azoxy Groups was published in 1975 in two parts, and the present book is the second volume of this publication. Since 1975 three supplementary volumes dealing with the chemistry of double-bonded functional groups were also published in the Series and these volumes contain much material on the chemistry of azoxy compounds. Several subjects were omitted from the original volume in 1975. These omissions have been corrected in the present volume, which contains chapters on "Detection, identification and determination," on NMR, on ESR, on PES, on pharmacology and toxicology, and also on safety and environmental factors.
In recent years C-glycoside chemistry has been one of the main topics in carbohydrate chemistry, not only because of the synthetic challenges posed, but also because C-glycosides have the potential to serve as carbohydrate analogues resistant to metabolic processes. Consequently, this class of compounds is currently receiving much interest as a potential source of therapeutic agents for clinical use. This book provides a broad coverage of the various synthetic methods available for the preparation of C-glycosides, and illustrates the interesting breadth of connections between carbohydrate chemistry and modern general synthetic organic chemistry by including topics such as transition-metal catalysis, radical chemistry, cycloaddition and rearrangement processes. In addition, in the final chapter of the book, the syntheses of C-di and trisaccharides reported through 1994 are reviewed. This well organised account of the synthetic chemistry in this field will prove to be very valuable to a wide range of researchers and advanced students, both as an introduction to the topic and for reference.
This book commences with a general introduction outlining the basic concepts of radical polymerization. This is followed by a chapter on radical reactions that is intended to lay the theoretical ground-work for the succeeding chapters on initiation, propagation and termination.
