Quasispecies and RNA Virus Evolution
Author: Esteban Domingo
Publisher:
Published: 2001
Total Pages: 188
ISBN-13: 9781587060106
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The Evolution and Emergence of RNA Viruses
Author: Edward C. Holmes
Publisher: Oxford University Press
Published: 2009-06-25
Total Pages: 267
ISBN-13: 0199211124
DOWNLOAD EBOOKWhile the study of viral evolution has developed rapidly in the last 30 years, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book intends to fill this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.
Virus as Populations
Author: Esteban Domingo
Publisher: Academic Press
Published: 2019-11-06
Total Pages: 426
ISBN-13: 0128163321
DOWNLOAD EBOOKVirus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
Quasispecies and RNA Virus Evolution
Author:
Publisher:
Published: 2001
Total Pages: 173
ISBN-13: 9781570596551
DOWNLOAD EBOOKOrigin and Evolution of Viruses
Author: Esteban Domingo
Publisher: Elsevier
Published: 2008-06-23
Total Pages: 573
ISBN-13: 0080564968
DOWNLOAD EBOOKNew viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. - NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution - UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups - SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Quasispecies: Concept and Implications for Virology
Author: Esteban Domingo
Publisher: Springer Science & Business Media
Published: 2006-02-19
Total Pages: 413
ISBN-13: 3540263977
DOWNLOAD EBOOKContinuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.
Viruses: Essential Agents of Life
Author: Günther Witzany
Publisher: Springer Science & Business Media
Published: 2012-11-13
Total Pages: 432
ISBN-13: 940074899X
DOWNLOAD EBOOKA renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.
Quasispecies: From Theory to Experimental Systems
Author: Esteban Domingo
Publisher: Springer
Published: 2016-03-18
Total Pages: 360
ISBN-13: 3319238981
DOWNLOAD EBOOKThis volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
Virus Bioinformatics
Author: Manja Marz
Publisher: MDPI
Published: 2020-02-21
Total Pages: 330
ISBN-13: 3039218824
DOWNLOAD EBOOKVirus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.
Plant Virus Evolution
Author: Marilyn J. Roossinck
Publisher: Springer Science & Business Media
Published: 2008-02-23
Total Pages: 227
ISBN-13: 3540757635
DOWNLOAD EBOOKThis book provides a comprehensive look at the field of plant virus evolution. It is the first book ever published on the topic. Individual chapters, written by experts in the field, cover plant virus ecology, emerging viruses, plant viruses that integrate into the host genome, population biology, evolutionary mechanisms and appropriate methods for analysis. It covers RNA viruses, DNA viruses, pararetroviruses and viroids, and presents a number of thought-provoking ideas.
