Penile Carcinoma

Penile Carcinoma

Author: Philippe E. Spiess

Publisher: Springer Nature

Published: 2021-09-22

Total Pages: 156

ISBN-13: 3030820602

DOWNLOAD EBOOK

This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families. Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.


Federal Power Commission Reports

Federal Power Commission Reports

Author: United States. Federal Power Commission

Publisher:

Published: 1975

Total Pages: 1824

ISBN-13:

DOWNLOAD EBOOK

Contains all the formal opinions and accompanying orders of the Federal Power Commission ... In addition to the formal opinions, there have been included intermediate decisions which have become final and selected orders of the Commission issued during such period.


Biomarkers and Immunotherapy for Genitourinary Tumors

Biomarkers and Immunotherapy for Genitourinary Tumors

Author: Hui Dai

Publisher: Frontiers Media SA

Published: 2024-04-02

Total Pages: 374

ISBN-13: 2832547109

DOWNLOAD EBOOK

Genitourinary tumors consist of a large variety of malignancies located in the urinary and the reproductive systems, mainly including prostate cancer, bladder cancer, and renal tumors. Apart from surgeries, various systemic treatments have been used for the whole-course management of genitourinary tumors, including radiation therapy, chemotherapy, and hormonal therapy. However, the characteristics of progression, metastasis, and drug resistance deriving from tumors require and breed novel treatments. Furthermore, exploring biomarkers of genitourinary tumors at the early stage is also beneficial to strengthen the management of patients with tumors. Additionally, the diagnostic and prognostic value of the potential biomarkers for immunotherapy and combined therapy of genitourinary tumors are underexplored. On the basis of precision treatments, the advent of immune-based therapies, including immune checkpoint inhibitors (ICIs, antibodies targeting PD-L1 /PD-1 and CTLA-4 pathways), tumor vaccines, and other therapies, has extended the scope of treatment modalities. FDA has until now approved the clinical application of immune checkpoint inhibitors in a wide range of diseases including some types of genitourinary tumors, whereas not all patients with genitourinary tumors are suitable for immune-based therapies, therefore, the understanding of its underlying mechanism is key to develop effective treatments based on current ICI-based immunotherapy.


Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics, E-Book

Advances in Penile and Testicular Cancer, An Issue of Urologic Clinics, E-Book

Author: Jeffrey M. Holzbeierlein

Publisher: Elsevier Health Sciences

Published: 2024-06-26

Total Pages: 145

ISBN-13: 0443246874

DOWNLOAD EBOOK

In this issue of Urologic Clinics of North America, guest editors Drs. Jeffrey M. Holzbeierlein and Philippe E. Spiess bring their considerable expertise to the topic of Advances in Penile and Testicular Cancer. Top experts in the field provide important clinical updates on the management of penile and scrotal cancer, discuss the current standards of care using evidence-based treatment guidelines, and provide insight on emerging discoveries. This issue provides critical information and updates needed to improve outcomes in patients with diseases that urologists do not see on a daily basis. Contains 12 relevant, practice-oriented topics, including the psychosocial impact of penile cancer: an unmet need; what is on the horizon in clinical trials for penile and testicular cancer; the use of miRNA to predict teratoma and viable GCT after chemotherapy; testicular cancers survivorship and fertility preservation; and more. Provides in-depth clinical reviews on advances in penile and testicular cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.


Diagnostic Pathology: Head and Neck,E-Book

Diagnostic Pathology: Head and Neck,E-Book

Author: Lester D. R. Thompson

Publisher: Elsevier Health Sciences

Published: 2022-05-02

Total Pages: 1200

ISBN-13: 0323794076

DOWNLOAD EBOOK

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of head and neck pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Head and Neck is a one-stop reference for accurate, complete pathology reports—ideal as a day-to-day reference or as a reliable teaching resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 325 new or evolving entities of the head and neck and endocrine organs Features updates on recent changes in the field and current information from the AJCC Cancer Staging Manual, 8th Edition, and the World Health Organization Classification of Head and Neck Tumours, 5th Edition Covers numerous new diagnostic entities, including intraductal carcinoma, sclerosing polycystic adenoma, microsecretory adenocarcinoma, adamantinoma-like Ewing sarcoma, SMARCB1- and SMARCA4-deficient carcinomas, and HPV-related multiphenotypic sinonasal carcinoma Contains major updates on sinonasal tract, salivary gland, and odontogenic tumors; oropharyngeal squamous cell carcinoma and its correct classification and staging; the recent significant reclassification of neuroendocrine tumors; and changes in terminology and identification for head and neck soft tissue tumors Suggests supporting studies in a realistic clinical context, with tables and immunohistochemical charts that assist with management decisions and prognostic outcome predictions Features more than 3,200 images, including full-color drawings of head and neck anatomy, development pathway drawings, staging protocol illustrations, and genetic pathway graphics; radiologic images, clinical photographs, and gross images; and histology, histochemistry, immunohistochemistry, in situ hybridization, and molecular images; as well as more than 2,600 additional online-only images Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care


Computational Collective Intelligence. Technologies and Applications

Computational Collective Intelligence. Technologies and Applications

Author: Jeng-Shyang Pan

Publisher: Springer

Published: 2010-11-06

Total Pages: 529

ISBN-13: 3642167322

DOWNLOAD EBOOK

This volume composes the proceedings of the Second International Conference on Computational Collective Intelligence––Technologies and Applications (ICCCI 2010), which was hosted by National Kaohsiung University of Applied Sciences and Wroclaw University of Technology, and was held in Kaohsiung City on November 10-12, 2010. ICCCI 2010 was technically co-sponsored by Shenzhen Graduate School of Harbin Institute of Technology, the Tainan Chapter of the IEEE Signal Processing Society, the Taiwan Association for Web Intelligence Consortium and the Taiwanese Association for Consumer Electronics. It aimed to bring together researchers, engineers and po- cymakers to discuss the related techniques, to exchange research ideas, and to make friends. ICCCI 2010 focused on the following themes: • Agent Theory and Application • Cognitive Modeling of Agent Systems • Computational Collective Intelligence • Computer Vision • Computational Intelligence • Hybrid Systems • Intelligent Image Processing • Information Hiding • Machine Learning • Social Networks • Web Intelligence and Interaction Around 500 papers were submitted to ICCCI 2010 and each paper was reviewed by at least two referees. The referees were from universities and industrial organizations. 155 papers were accepted for the final technical program. Four plenary talks were kindly offered by: Gary G. Yen (Oklahoma State University, USA), on “Population Control in Evolutionary Multi-objective Optimization Algorithm,” Chin-Chen Chang (Feng Chia University, Taiwan), on “Applying De-clustering Concept to Information Hiding,” Qinyu Zhang (Harbin Institute of Technology, China), on “Cognitive Radio Networks and Its Applications,” and Lakhmi C.