Protein Kinase C Regulation of Stimulus-secretion Coupling in the Rat Peritoneal Mast Cell
Author: Firdaus S. Dhabhar
Publisher:
Published: 1990
Total Pages: 170
ISBN-13:
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Author: Firdaus S. Dhabhar
Publisher:
Published: 1990
Total Pages: 170
ISBN-13:
DOWNLOAD EBOOKAuthor: C. P. England
Publisher:
Published: 1986
Total Pages:
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DOWNLOAD EBOOKAuthor: Jerome Brody
Publisher: CRC Press
Published: 1993-03-30
Total Pages: 684
ISBN-13: 9780824788131
DOWNLOAD EBOOKThis reference offers detailed discussions of the basic aspects of signal transduction, and examines their applications in lung cell biology. Providing an overview of current research directions, Signal Transduction in Lung Cells covers: the structure and function of receptors; the structure and regulation of G proteins; second messenger systems including kinases and phosphatases; airway and alveolar cells; smooth muscle cells; inflammatory and immune cells; muscle tone, ion channels, growth factors and cytokines.;With over 1900 literature citations and figures, Signal Transduction in Lung Cells is intended as a resource for pulmonologists, physiologists, molecular and cell biologists, pharmacologists, and graduate and medical school students in these disciplines.
Author: Ehud Razin
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 438
ISBN-13: 1461221544
DOWNLOAD EBOOKFocussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.
Author: Stephen T. Holgate
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 293
ISBN-13: 9400912870
DOWNLOAD EBOOKIn 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.
Author:
Publisher:
Published: 2003
Total Pages: 968
ISBN-13:
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Publisher:
Published: 1997
Total Pages: 1850
ISBN-13:
DOWNLOAD EBOOKAuthor: Danton H. O'Day
Publisher: Academic Press
Published: 2012-12-02
Total Pages: 285
ISBN-13: 0323141455
DOWNLOAD EBOOKSignal Transduction during Biomembrane Fusion begins with three review articles that put the problem of signal transduction and biomembrane fusion into a general perspective. Each subsequent chapter begins with an introduction which reviews past work on a specific biological system. The authors' current research is then detailed. The chapters conclude with final comments wherein the contributors express viewpoints about the general significance and progression of their work. This book comprises 12 chapters, with the first focusing on signal transduction during biomembrane fusion. The succeeding chapters then discuss the ""focal membrane fusion"" model; osmotic phenomena in membrane fusion; cell signaling and regulation of exocytosis at fertilization of the egg; and signal transduction during exocytosis in mast cells. Other chapters cover protein kinase c and granule membrane fusion; GTP-binding proteins and formation of secretory vesicles; and signal transduction during phagocytosis. The remaining chapters discuss calcium signal transduction pathway and myoblast fusion; phospholipid metabolism during calcium-regulated myoblast fusion; protein kinase c, membrane protein phosphorylation, and calcium influx in chick embryo skeletal myoblast fusion; and signal transduction and cell fusion in dictyostelium. This book will be of interest to practitioners in the fields of neurobiology, zoology, and the biological sciences.
Author: Society of General Physiologists. Symposium
Publisher: Rockefeller Univ. Press
Published: 1989
Total Pages: 380
ISBN-13:
DOWNLOAD EBOOKAuthor: Gerald J. Gleich
Publisher: CRC Press
Published: 2019-08-16
Total Pages: 527
ISBN-13: 1000715752
DOWNLOAD EBOOKThis work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.