Proteases, Protease Inhibitors and Protease-Derived Peptides
Author: J. Cheronis
Publisher: Birkhäuser
Published: 2014-01-14
Total Pages: 0
ISBN-13: 9783034873970
DOWNLOAD EBOOKRead and Download eBook Full
Author: J. Cheronis
Publisher: Birkhäuser
Published: 2014-01-14
Total Pages: 0
ISBN-13: 9783034873970
DOWNLOAD EBOOKAuthor: J. Cheronis
Publisher: Birkhäuser
Published: 2012-04-19
Total Pages: 248
ISBN-13: 9783034873994
DOWNLOAD EBOOKProteases, Protease-Derived Peptides and Protease Inhibitors Many physiological as weil as pathophysiological processes are mediated by proteases and the products of their actions, protease-derived peptides. However, the uncontrolled activity of proteases can be extraordinarily destructive and dangerous to normal biologie systems. As a result, biology has gone to great lengths to control the activities of the proteases involved in these systems by developing aseries of both highly specific (regulatory) and non-specific (protective) anti-proteases. The protease/anti-protease balancing activities include the normal homeostatic processes of clotting and clot lysis, hormonal regulation of blood pressure and the control of the inflammatory response represented by both the humoral (the kallikrein-kinin and complement systems) and cellular (neutrophil and macrophage derived proteases) components of the inflammation. Examples of successful therapies directed at these protease dependent systems include the use of warfarin and heparin to control thrombosis and streptokinase or tissue plasminogen activator (tPA) for the acceleration of clot dissolution. Similarly, the use of angiotensin converting enzyme (ACE, a type of limited activity protease or peptidase) inhibitors has made a significant impact on the treatment of hypertension. Lastly, the restitution of normal antiprotease levels by the infusion of the purified protein in patients with genetic alpha-1-antiprotease deficiency is regularly being used to reduce the rate of lung function 1055 caused by the unopposed activity of human neutrophil elastase in these individuals.
Author: J. Cheronis
Publisher: Birkhäuser
Published: 1993-06-01
Total Pages: 0
ISBN-13: 9783764328689
DOWNLOAD EBOOKAuthor: Yehudith Birk
Publisher: Springer Science & Business Media
Published: 2003-04-08
Total Pages: 192
ISBN-13: 9783540001188
DOWNLOAD EBOOKPlant protease inhibitors are diverse in number & specificity towards various proteolytic enzymes.
Author: Nobuhiko Katunuma
Publisher: IOS Press
Published: 1997
Total Pages: 224
ISBN-13: 9789051992922
DOWNLOAD EBOOKThe work presents articles on proteases and their inhibitors as mediators of biological functions. Topics addressed: cathepsin B and L; MHC and peptide interaction; procathepsin L; cysteine proteinases; selective neuronal cell death; HIV and influenza virus; tumor invasion; gingivitis; bacterial infection. Readers: professionals in the area of molecular medicine, biochemists, molecular biologists, clinical pharmacologists, pharmaceutical companies.
Author: Laszlo Polgar
Publisher: CRC Press
Published: 1989-01-31
Total Pages: 236
ISBN-13: 9780849369018
DOWNLOAD EBOOKA uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.
Author: Ben M. Dunn
Publisher: John Wiley & Sons
Published: 2015-02-02
Total Pages: 336
ISBN-13: 1118995287
DOWNLOAD EBOOKThis book focuses on peptides as drugs, a growing area ofpharmaceutical research and development. It helps readers solveproblems of discovering, developing, producing, and deliveringpeptide-based drugs. • Identifies promising new areas in peptide drugdiscovery • Includes chapters on discovery from natural sources,metabolic modification, and drug delivery • Overviews separation methods and techniques foranalysis, bond formation, and purification • Offers readers both a professional reference and atext or resource for graduate-level students
Author: H. John Smith
Publisher: CRC Press
Published: 2002-03-28
Total Pages: 440
ISBN-13: 0203219171
DOWNLOAD EBOOKCellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the
Author: Keitarō Hiromi
Publisher: Elsevier Publishing Company
Published: 1985
Total Pages: 538
ISBN-13:
DOWNLOAD EBOOKAuthor: Erwin E. Sterchi
Publisher: Springer Science & Business Media
Published: 2013-11-11
Total Pages: 371
ISBN-13: 3642598161
DOWNLOAD EBOOKFollowing an overview on proteolytic enzyme assays, this text covers procedures on how to investigate and study proteases. It describes the use of specific restriction proteases as well as inhibitors of proteases to prevent unwanted proteolysis.