Proteases New Perspectives
Proteases New Perspectives

Author: Vito Turk

Publisher: Birkhäuser

Published: 2012-12-06

Total Pages: 238

ISBN-13: 303488737X

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This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

Proteases New Perspectives
Proteases New Perspectives

Author: Vito Turk

Publisher:

Published: 1999-12-01

Total Pages: 252

ISBN-13: 9783034887380

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This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

New Perspectives in Plant Protection
New Perspectives in Plant Protection

Author: Ali R. Bandani

Publisher: BoD – Books on Demand

Published: 2012-04-11

Total Pages: 262

ISBN-13: 953510490X

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Crop losses by pests (insects, diseases and weeds) are as old as plant themselves but as agriculture are intensified and cropping patterns including the cultivation of high yielding varieties and hybrids are changing over time the impact of the pests becoming increasingly important. Approximately less than 1000 insect species (roughly 600-800 species), 1500 -2000 plant species, numerous fungal, bacterial and nematode species as well as viruses are considered serious pests in agriculture. If these pests were not properly controlled, crop yields and their quality would drop, considerably. In addition production costs as well as food and fiber prices are increased. The current book is going to put Plant Protection approaches in perspective.

Plant Protease Inhibitors
Plant Protease Inhibitors

Author: Yehudith Birk

Publisher: Springer Science & Business Media

Published: 2003-04-08

Total Pages: 192

ISBN-13: 9783540001188

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Plant protease inhibitors are diverse in number & specificity towards various proteolytic enzymes.

Plant Proteases
Plant Proteases

Author: Mercedes Diaz-Mendoza

Publisher: Frontiers Media SA

Published: 2020-01-24

Total Pages: 157

ISBN-13: 2889633993

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Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.

New Perspectives in Prostate Cancer
New Perspectives in Prostate Cancer

Author: Arie Belldegrun

Publisher: CRC Press

Published: 1998-03-01

Total Pages: 472

ISBN-13: 9780203091968

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A summary of the highlights of the Second International Forum on Prostate Cancer, held in Cambridge in 1998. The contributors include scientists, epidemiologists and clinicians who provide both a North American and a European view of treatment. The patient's perspective is also considered.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades
TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author: Wolfgang B. Liedtke, MD, PH.D.

Publisher: CRC Press

Published: 2006-09-29

Total Pages: 502

ISBN-13: 1420005847

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Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Proteases in Apoptosis: Pathways, Protocols and Translational Advances
Proteases in Apoptosis: Pathways, Protocols and Translational Advances

Author: Kakoli Bose

Publisher: Springer

Published: 2015-08-06

Total Pages: 258

ISBN-13: 3319194976

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This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics is recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.

Handbook of Proteolytic Enzymes, Volume 1
Handbook of Proteolytic Enzymes, Volume 1

Author: Alan J. Barrett

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 1182

ISBN-13: 0080984150

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Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.