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Author: Carl D. B. Banner
Publisher:
Published: 1992
Total Pages: 280
ISBN-13:
DOWNLOAD EBOOKThese 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
Author: Carl D. B. Banner
Publisher:
Published: 1992
Total Pages: 282
ISBN-13:
DOWNLOAD EBOOKThese 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
Author: Uday Kishore
Publisher: BoD – Books on Demand
Published: 2013-05-15
Total Pages: 642
ISBN-13: 9535110888
DOWNLOAD EBOOKThis book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
Author:
Publisher:
Published: 1992
Total Pages: 1064
ISBN-13:
DOWNLOAD EBOOKAuthor: Khalid Iqbal
Publisher: John Wiley & Sons
Published: 2001
Total Pages: 900
ISBN-13:
DOWNLOAD EBOOKAlzheimer's Disease is an ever-present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume in the series: Provides a uniques source of reference to the important work being done in this field Gives academics and clinicians an opportunity to learn about cutting edge developments Covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
Author: Robert A. Nichols
Publisher: Frontiers Media SA
Published: 2022-04-06
Total Pages: 209
ISBN-13: 2889744582
DOWNLOAD EBOOKAuthor: Dennis J. Selkoe
Publisher: Cold Spring Harbor Perspective
Published: 2012
Total Pages: 0
ISBN-13: 9781936113446
DOWNLOAD EBOOKAlzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.
Author: Charlotte E. Teunissen
Publisher: Humana
Published: 2022-05-19
Total Pages: 236
ISBN-13: 9781071613214
DOWNLOAD EBOOKThis volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Author: Sajal Chakraborti
Publisher: Springer
Published: 2017-07-13
Total Pages: 516
ISBN-13: 9811031622
DOWNLOAD EBOOKThis book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Author: Einar M. Sigurdsson
Publisher: Springer Science & Business Media
Published: 2008-02-02
Total Pages: 390
ISBN-13: 1592598749
DOWNLOAD EBOOKA proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
