Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies

Author: Jeffrey Noebels

Publisher: OUP USA

Published: 2012-06-29

Total Pages: 1258

ISBN-13: 0199746540

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Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.


Cellular and Molecular Neurophysiology

Cellular and Molecular Neurophysiology

Author: Constance Hammond

Publisher: Academic Press

Published: 2014-12-30

Total Pages: 444

ISBN-13: 0123973228

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Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text


Voltage Gated Sodium Channels

Voltage Gated Sodium Channels

Author: Peter C. Ruben

Publisher: Springer Science & Business Media

Published: 2014-04-15

Total Pages: 328

ISBN-13: 3642415881

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A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.


Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease

Author: Venkataramana K Sidhaye

Publisher: Academic Press

Published: 2017-03-09

Total Pages: 277

ISBN-13: 0128038810

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Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. - Provides a single source of information on lung epithelial junctions and transporters - Discusses of the role of the epithelium in lung homeostasis and disease - Includes capsule summaries of main conclusions as well as highlights of future directions in the field - Covers the mechanistic basis for lung disease for a range of audiences


The Neuron

The Neuron

Author: Irwin B. Levitan

Publisher: Oxford University Press, USA

Published: 2002

Total Pages: 640

ISBN-13: 9780195145236

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Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.


Pharmacology of Potassium Channels

Pharmacology of Potassium Channels

Author: Nikita Gamper

Publisher: Springer Nature

Published: 2021-09-27

Total Pages: 546

ISBN-13: 3030840522

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The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.


Neuromodulation

Neuromodulation

Author: Irwin B. Levitan

Publisher:

Published: 1987

Total Pages: 316

ISBN-13: 9780195040975

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"Traditional neuroscience texts have stressed the output of neurons, how they turn postsynaptic targets on or off, cause muscles to twitch or convert photons into electrical pulses. Neuromodulation alters that emphasis to examine how the responses of nerve cells can be modified. Because a neuron's performance can be modulated, brains of all animals exhibit the amazing capacity to learn. Presenting the best-studied examples, Kaczmarek and Levitan provide the first detailed review of those potassium and calcium channels whose functions are modulated through receptor-mediated second messenger mechanisms and that are thought to underlie many important kinds of neuronal plasticity. This book, which covers up-to-date biophysical work in both vertebrate and invertebrate neurons, will be greatly appreciated by the readership the authors wish to reach: neurophysiological biochemists and biochemical neurophysiologists interested in understanding how behavior results from the action of nerve cells."--James H. Schwartz, M.D., Ph.D., Columbia University College of Physicians and Surgeons


Clinical Arrhythmology and Electrophysiology E-Book

Clinical Arrhythmology and Electrophysiology E-Book

Author: Ziad Issa

Publisher: Elsevier Health Sciences

Published: 2018-08-07

Total Pages: 1310

ISBN-13: 0323568823

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Part of the highly regarded Braunwald's family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more. - Key topics such as inherited channelopathies; atrial fibrillation; ventricular tachycardia; hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, and congenital heart disease. - Dozens of videos depicting key mapping techniques, and fluoroscopy images illustrating techniques for electrophysiologic catheter positioning, atrial septal puncture, and pericardial access, cryoablation, and left atrial appendage exclusion procedures. - Grounds clinical techniques in basic science for managing complex patients. - Consistent organization, showing every arrhythmia in a similar manner for quick reference. - New management options with increased clinical content. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.