Progress in Polyamine Research
Progress in Polyamine Research

Author: V. Zappia

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 755

ISBN-13: 1468456377

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This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.

Polyamine Drug Discovery
Polyamine Drug Discovery

Author: Patrick Woster

Publisher: Royal Society of Chemistry

Published: 2011-11-07

Total Pages: 303

ISBN-13: 1849733090

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Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.

Polyamines
Polyamines

Author: Anthony E. Pegg

Publisher: Humana Press

Published: 2011-04-06

Total Pages: 524

ISBN-13: 9781617790355

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Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.

The Genus Yersinia:
The Genus Yersinia:

Author: Robert D. Perry

Publisher: Springer Science & Business Media

Published: 2007-09-25

Total Pages: 454

ISBN-13: 0387721231

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The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

A Guide to the Polyamines
A Guide to the Polyamines

Author: Seymour Stanley Cohen

Publisher: Oxford University Press, USA

Published: 1998

Total Pages: 632

ISBN-13:

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The polyamines are ubiquitous and essential organic cations in prokaryotic and eukaryotic cells. This book is a comprehensive survey of the development of knowledge of their physiological and structural roles. Currently, the genetic and regulatory determinants of the amines and their cellular composition are being explored actively as parameters of normal physiology and aberrant pathologies. Cancer, virus infection, and protozoan parasitism are major examples of the later groups. Studies of the control of polyamine metabolism are providing important therapeutic leads. Further, the structural roles of the amines are being determined at molecular levels, contributing to the understanding of polynucleotide and protein organization and interaction, as well as to the solution of problems of genome transfer. These subjects describe a burgeoning biochemical area involving compounds whose roles in cytoplasmic and nuclear function include numerous aspects of organelle structure, polymer synthesis, and interactions.

Protective Chemical Agents in the Amelioration of Plant Abiotic Stress
Protective Chemical Agents in the Amelioration of Plant Abiotic Stress

Author: Aryadeep Roychoudhury

Publisher: John Wiley & Sons

Published: 2020-04-30

Total Pages: 702

ISBN-13: 1119551641

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A guide to the chemical agents that protect plants from various environmental stressors Protective Chemical Agents in the Amelioration of Plant Abiotic Stress offers a guide to the diverse chemical agents that have the potential to mitigate different forms of abiotic stresses in plants. Edited by two experts on the topic, the book explores the role of novel chemicals and shows how using such unique chemical agents can tackle the oxidative damages caused by environmental stresses. Exogenous application of different chemical agents or chemical priming of seeds presents opportunities for crop stress management. The use of chemical compounds as protective agents has been found to improve plant tolerance significantly in various crop and non-crop species against a range of different individually applied abiotic stresses by regulating the endogenous levels of the protective agents within plants. This important book: Explores the efficacy of various chemical agents to eliminate abiotic stress Offers a groundbreaking look at the topic and reviews the most recent advances in the field Includes information from noted authorities on the subject Promises to benefit agriculture under stress conditions at the ground level Written for researchers, academicians, and scientists, Protective Chemical Agents in the Amelioration of Plant Abiotic Stress details the wide range of protective chemical agents, their applications, and their intricate biochemical and molecular mechanism of action within the plant systems during adverse situations.

Plant Hormones
Plant Hormones

Author: P.J. Davies

Publisher: Springer Science & Business Media

Published: 2013-12-01

Total Pages: 843

ISBN-13: 9401104735

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Plant hormones play a crucial role in controlling the way in which plants growand develop. Whilemetabolism providesthepowerand buildingblocks for plant life, it is the hormones that regulate the speed of growth of the individual parts and integrate these parts to produce the form that we recognize as a plant. In addition, theyplayacontrolling role inthe processes of reproduction. This book is a description ofthese natural chemicals: how they are synthesizedand metabolized; howthey work; whatwe knowoftheir molecular biology; how we measure them; and a description ofsome ofthe roles they play in regulating plant growth and development. Emphasis has also been placed on the new findings on plant hormones deriving from the expanding use ofmolecular biology as a tool to understand these fascinating regulatory molecules. Even at the present time, when the role of genes in regulating all aspects of growth and development is considered of prime importance, it is still clear that the path of development is nonetheless very much under hormonal control, either via changes in hormone levels in response to changes in gene transcription, or with the hormones themselves as regulators ofgene transcription. This is not a conference proceedings, but a selected collection ofnewly written, integrated, illustrated reviews describing our knowledge of plant hormones, and the experimental work that is the foundation of this knowledge.

Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

Author: JUCKER

Publisher: Birkhäuser

Published: 2013-03-08

Total Pages: 401

ISBN-13: 3034871449

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Volume 39 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with polyamines as tumor markers; the histamine (H3)-receptor and its role as a general regulatory system; with cytokines as immunosti mulants and immunosuppressants as well as potential anticancer agents; with fibrinolysis and clinical use of thrombolytic agents; and with catechol O-methyltransferase and its inhibitors, which are of potential interest in the treatment of Parkinson's disease. An exten sive review on antihistamines (HI) provides an excellent survey of this area in drug research. In the 32 years that "Progress in Drug Research" has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and, last but not least, the review ers have all contributed greatly to the success of the series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series.