Progress in Enantioselective Cu(I)-catalyzed Formation of Stereogenic Centers
Progress in Enantioselective Cu(I)-catalyzed Formation of Stereogenic Centers

Author: Syuzanna R. Harutyunyan

Publisher: Springer

Published: 2016-04-30

Total Pages: 229

ISBN-13: 331933414X

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The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal.

Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis

Author: Montserrat Diéguez

Publisher: John Wiley & Sons

Published: 2018-02-21

Total Pages: 431

ISBN-13: 3527804072

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An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

C-H Activation for Asymmetric Synthesis
C-H Activation for Asymmetric Synthesis

Author: Françoise Colobert

Publisher: John Wiley & Sons

Published: 2019-11-12

Total Pages: 294

ISBN-13: 3527343407

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Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Quaternary Stereocenters
Quaternary Stereocenters

Author: Jens Christoffers

Publisher: John Wiley & Sons

Published: 2006-05-12

Total Pages: 359

ISBN-13: 3527606971

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Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions

Asymmetric Organocatalysis Combined with Metal Catalysis
Asymmetric Organocatalysis Combined with Metal Catalysis

Author: Bruce A. Arndtsen

Publisher: Springer Nature

Published: 2020-04-24

Total Pages: 211

ISBN-13: 3030438511

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The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.

Chiral Amine Synthesis
Chiral Amine Synthesis

Author: Thomas C. Nugent

Publisher: John Wiley & Sons

Published: 2010-01-14

Total Pages: 520

ISBN-13: 9783527629558

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This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a "Who's Who" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods. Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.

Asymmetric Phase Transfer Catalysis
Asymmetric Phase Transfer Catalysis

Author: Keiji Maruoka

Publisher: John Wiley & Sons

Published: 2008-09-08

Total Pages: 228

ISBN-13: 3527622632

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Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Rhodium Catalyzed Hydroformylation
Rhodium Catalyzed Hydroformylation

Author: Piet W.N.M. van Leeuwen

Publisher: Springer Science & Business Media

Published: 2006-04-11

Total Pages: 291

ISBN-13: 0306469472

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In the last decade there have been numerous advances in the area of rhodium-catalyzed hydroformylation, such as highly selective catalysts of industrial importance, new insights into mechanisms of the reaction, very selective asymmetric catalysts, in situ characterization and application to organic synthesis. The views on hydroformylation which still prevail in the current textbooks have become obsolete in several respects. Therefore, it was felt timely to collect these advances in a book. The book contains a series of chapters discussing several rhodium systems arranged according to ligand type, including asymmetric ligands, a chapter on applications in organic chemistry, a chapter on modern processes and separations, and a chapter on catalyst preparation and laboratory techniques. This book concentrates on highlights, rather than a concise review mentioning all articles in just one line. The book aims at an audience of advanced students, experts in the field, and scientists from related fields. The didactic approach also makes it useful as a guide for an advanced course.

Pincer Compounds
Pincer Compounds

Author: David Morales-Morales

Publisher: Elsevier

Published: 2018-04-11

Total Pages: 756

ISBN-13: 0128129328

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Pincer Compounds: Chemistry and Applications offers valuable state-of-the-art coverage highlighting highly active areas of research—from mechanistic work to synthesis and characterization. The book focuses on small molecule activation chemistry (particularly H2 and hydrogenation), earth abundant metals (such as Fe), actinides, carbene-pincers, chiral catalysis, and alternative solvent usage. The book covers the current state of the field, featuring chapters from renowned contributors, covering four continents and ranging from still-active pioneers to new names emerging as creative strong contributors to this fascinating and promising area. Over a decade since the publication of Morales-Morales and Jensen's The Chemistry of Pincer Compounds (Elsevier 2007), research in this unique area has flourished, finding a plethora of applications in almost every single branch of chemistry—from their traditional application as very robust and active catalysts all the way to potential biological and pharmaceutical applications. - Describes the chemistry and applications of this important class of organometallic and coordination compounds - Includes contributions from global leaders in the field, featuring pioneers in the area as well as emerging experts conducting exciting research on pincer complexes - Highlights areas of promising and active research, including small molecule activation, earth abundant metals, and actinide chemistry

Advances in Drug discovery and Quality Evaluation
Advances in Drug discovery and Quality Evaluation

Author: Xuetao Xu

Publisher: Frontiers Media SA

Published: 2023-11-24

Total Pages: 120

ISBN-13: 283253967X

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Drug discovery and quality evaluation are very important for human health. Drugs from chemical synthesis and natural products are a very important branch in drug discovery. The highly efficient synthetic methodology development and pharmacological evaluation of related active agents, as essential steps to developing corresponding innovative drugs, are always research frontiers for organic chemists and medicinal chemists. Meanwhile, the drug quality evaluation is an important guarantee for the clinical application of drugs and the efficacy of drugs. Therefore, we wanted to organize this article collection for the presentation of the high-quality work from internationally recognized researchers to promote academic communication among scientific researchers focusing on medicinal and pharmaceutical chemistry. In recent years, the research community has witnessed significant advances in the development of the discovery of novel natural products, design and synthesis of bioactive molecules, synthetic methodology, and drug quality evaluation. Therefore, we hope to be able to summarize and display the latest developments in the design and synthesis of bioactive molecules, synthetic methodologies, the discovery of novel natural products, as well as drugs quality evaluation through the collection of this album, and provide new methods and template molecules for the subsequent development of innovative drug molecules.