Medical Isotope Production Without Highly Enriched Uranium
Medical Isotope Production Without Highly Enriched Uranium

Author: National Research Council

Publisher: National Academies Press

Published: 2009-06-27

Total Pages: 220

ISBN-13: 0309130395

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This book is the product of a congressionally mandated study to examine the feasibility of eliminating the use of highly enriched uranium (HEU2) in reactor fuel, reactor targets, and medical isotope production facilities. The book focuses primarily on the use of HEU for the production of the medical isotope molybdenum-99 (Mo-99), whose decay product, technetium-99m3 (Tc-99m), is used in the majority of medical diagnostic imaging procedures in the United States, and secondarily on the use of HEU for research and test reactor fuel. The supply of Mo-99 in the U.S. is likely to be unreliable until newer production sources come online. The reliability of the current supply system is an important medical isotope concern; this book concludes that achieving a cost difference of less than 10 percent in facilities that will need to convert from HEU- to LEU-based Mo-99 production is much less important than is reliability of supply.

Molybdenum-99 for Medical Imaging
Molybdenum-99 for Medical Imaging

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2016-11-28

Total Pages: 264

ISBN-13: 0309445310

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The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.

Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets
Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2018-03-12

Total Pages: 87

ISBN-13: 030946627X

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Participants of the July 17-18, 2017, symposium titled Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets examined current trends in molybdenum-99 production, prospects for new global supplies, and technical, economic, regulatory, and other considerations for supplying molybdenum-99 to global markets. This publication summarizes the presentations and discussions from the symposium.

Cyclotron Based Production of Technetium-99m
Cyclotron Based Production of Technetium-99m

Author: International Atomic Energy Agency

Publisher:

Published: 2017

Total Pages: 0

ISBN-13: 9789201029164

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This publication presents a comprehensive overview of the technologies involved in the production of cyclotron based 99mTc. These would include techniques relevant to preparation of targets, irradiation of targets under high beam currents, target processing, target recovery and quality control of the final product. The publication provides broad information, well supported with references, on improved production routes and improved separation and purification of cyclotron based 99mTc. These approaches achieve high specific activity and chemical purity of 99mTc suitable for labelling molecules of medical interest and also enable spare capacity to be available at medical cyclotron centres. The readership of this publication is scientists interested in translating this technology to practice, technologists already working with cyclotrons wanting to enhance the utility of the existing machines and managers who are in the process of setting up facilities in their countries. Students working towards higher level degrees in related fields may also benefit from this publication.

Isotopes for Medicine and the Life Sciences
Isotopes for Medicine and the Life Sciences

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1995-01-27

Total Pages: 144

ISBN-13: 0309176697

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Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.

Nuclear Energy Today
Nuclear Energy Today

Author: OECD Nuclear Energy Agency

Publisher: OECD

Published: 2003

Total Pages: 120

ISBN-13:

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As energy demand increases in line with the expansion of the world's leading economies and the growth of developing economies, a key challenge remains of how to provide the energy levels required while protecting our environment and conserving natural resources. Nuclear energy is a complex and controversial technology but also has the potential to provide considerable benefits. This publication explores a range of issues involved in the use of nuclear energy, including safety aspects, whether its use is economically competitive, its role in meeting greenhouse gas reduction targets, how to manage the radioactive waste it generates, whether its use increase the risk of proliferation of nuclear weapons, security of resources, and its potential role in the future.

The Supply of Medical Isotopes
The Supply of Medical Isotopes

Author:

Publisher:

Published: 2019

Total Pages: 122

ISBN-13: 9789264625099

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This report explores the main reasons behind the unreliable supply of Technetium-99m (Tc-99m) in health-care systems and policy options to address the issue. Tc-99m is used in 85% of nuclear medicine diagnostic scans performed worldwide – around 30 million patient examinations every year. These scans allow diagnoses of diseases in many parts of the human body, including the skeleton, heart and circulatory system, and the brain. Medical isotopes are subject to radioactive decay and have to be delivered just-in-time through a complex supply chain. However, ageing production facilities and a lack of investment have made the supply of Tc-99m unreliable. This report analyses the use and substitutability of Tc-99m in health care, health-care provider payment mechanisms for scans, and the structure of the supply chain. It concludes that the main reasons for unreliable supply are that production is not economically viable and that the structure of the supply chain prevents producers from charging prices that reflect the full costs of production and supply.

Nuclear Terrorism and Global Security
Nuclear Terrorism and Global Security

Author: Alan J. Kuperman

Publisher: Routledge

Published: 2013-04-17

Total Pages: 257

ISBN-13: 1135105863

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This book examines the prospects and challenges of a global phase-out of highly enriched uranium—and the risks of this material otherwise being used by terrorists to make atom bombs. Terrorist groups, such as Al Qaeda, have demonstrated repeatedly that they seek to acquire nuclear weapons. Unbeknownst even to many security specialists, tons of bomb-grade uranium are trafficked legally each year for ostensibly peaceful purposes. If terrorists obtained even a tiny fraction of this bomb-grade uranium they could potentially construct a nuclear weapon like the one dropped on Hiroshima that killed tens of thousands. Nuclear experts and policymakers have long known of this danger but – so far – have taken only marginal steps to address it. This volume begins by highlighting the lessons of past successes where bomb-grade uranium commerce has been eliminated, such as from Argentina’s manufacture of medical isotopes. It then explores the major challenges that still lie ahead: for example, Russia’s continued use of highly enriched uranium (HEU) in dozens of nuclear facilities. Each of the book’s thirteen case studies offers advice for reducing HEU in a specific sector. These insights are then amalgamated into nine concrete policy recommendations for U.S. and world leaders to promote a global phase-out of bomb-grade uranium. This book will be of much interest to students of nuclear proliferation, global governance, international relations and security studies.

Safeguards Techniques and Equipment
Safeguards Techniques and Equipment

Author: International Atomic Energy Agency

Publisher:

Published: 2011

Total Pages: 146

ISBN-13: 9789201189103

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The 1990s saw significant developments in the global non-proliferation landscape, resulting in a new period of safeguards development. The current publication, which is the second revision and update of IAEA/NVS/1, is intended to give a full and balanced description of the safeguards techniques and equipment used for nuclear material accountancy, containment and surveillance measures, environmental sampling, and data security. New features include a section on new and novel technologies. As new verification measures continue to be developed, the material in this book will be reviewed periodically and updated versions issued.