Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
With the ever-increasing incidence of harmful cyanobacterial algal blooms, this monograph has added urgency and will be essential reading for all sorts of researchers, from neuroscientists to cancer research specialists. The volume contains the proceedings of the 2005 International Symposium on Cyanobacterial Harmful Algal Blooms, and has been edited by H. Kenneth Hudnell, of the US Environmental Protection Agency. It contains much of the most recent research into the subject.
Learn about the wonders of Lake Erie and Lake St. Clair in this fascinating and readable book. The most comprehensive reference source available about the lakes, Lake Erie and Lake St. Clair Handbook is an ideal guide for anglers, boaters, swimmers, beach walkers—anyone who uses and enjoys the lakes. The handbook explains, in simple terms, the reasons for the scenic beauty and the natural events that occur in the coastal and offshore waters of Lake Erie and Lake St. Clair, including the St. Clair, Detroit, and Niagara rivers extending from Sarnia, Ontario, to Niagara-on-the-Lake, New York. Individual chapters focus on the land, air, water, and life forms that comprise the natural history and environment of the region—the shoreline topography, wind and weather patterns, water temperature cycles and water level changes, the ecology, and indigenous animal life. Lake Erie and Lake St. Clair Handbook enhances our understanding and appreciation of the lakes and their surroundings by addressing fundamental questions about the Lake Erie region: • how Lake Erie was formed through glacial processes • why daily and seasonal weather patterns occur • causes of the water currents and waves • causes of temperature patterns in the lakes • the location of productive reef features • the species of fish and birds found in the area • the importance of the wetlands • the effect of current and past pollution on the aquatic life in the lakes
This guidebook, now thoroughly updated and revised in its second edition, gives comprehensive advice on the designing and setting up of monitoring programmes for the purpose of providing valid data for water quality assessments in all types of freshwater bodies. It is clearly and concisely written in order to provide the essential information for all agencies and individuals responsible for the water quality.
