Introduction to the diagnosis of diseases of the breast Concepts basic to the analysis of epithelial proliferations Conventional ductal proliferations Apocrine proliferations Mucinous proliferations Lobular proliferations Concepts basic to the analysis of papillary proliferations Papilloma Papillary carcinoma Micropapillary proliferations Concepts basic to the diagnosis of sclerosing lesions Sclerosing adenosis Radial scar Low grade invasive ductal carcinoma Concepts basic to the analysis of fibroepithelial lesions Fibroadenoma Myxoid fibroadenoma Phyllodes tumor Hamartoma and fibroadenoma variant Pseudoangiomatous stromal hyperplasia.
This comprehensive volume reviews current topics and controversies in diagnostic breast pathology, and addresses frequently encountered diagnostic problems using a question and answer format and case presentations. Emphasis is placed on the diagnostic approach as it relates to morphology, clinical and radiographic correlation, differential diagnosis, and ancillary testing including immunohistochemical and molecular analyses. Answers are provided and serve as a practical, evidence-based, and problem solving guide to diagnostic issues having significant impacts on clinical management. Common but diagnostically challenging entities such as papillary lesions and fibroepithelial lesions are discussed in detail, as well as special types of breast cancer including solid papillary carcinoma, lobular lesions and its variants. Uncommon breast lesions such as mesenchymal, lymphoid, and metastatic lesions are also covered. Chapters discuss genetic alterations and molecular abnormalities in breast cancer, and commonly encountered interpretation dilemmas on immunohistochemistry in breast cancer and metastatic cancer to the breast with a focus on prognostic and predictive tumor biomarkers.
Breast cancer is the second leading cause of cancer death in women in the United States. For the pathologist, almost any breast lesion may produce diagnostic difficulty, especially due to frequently small samples (core biopsy specimens) and a variety of mimics and variants seen in specific types of lesions. Additionally, the difficulty of breast lesion diagnosis has risen dramatically in recent years due to the increased emphasis on stratifying patients for appropriate therapy on an individual basis; the wider range of both local and systemic therapeutic options, and the potential for earlier diagnosis through increased mammographic breast screening leading to a higher likelihood of a favorable outcome. Difficult Diagnoses in Breast Pathology will have a special focus on the most difficult diagnostic problems in breast disease for the surgical pathologist: needle core biopsy interpretation, diagnosis of precursor lesions and early stage disease, recognition of neoplastic mimics and other misleading variants, and other particularly difficult areas including appropriate use of newer immunohistochemical markers, where appropriate. Prognostic questions and early staging of special importance in the pathologist's collaboration with oncology clinicians and, increasingly, in informing patients and participating in ongoing management assessment. Throughout, the emphasis will be on a visual presentation with high-quality images on the more difficult problems and questions that the pathologist is likely to have in evaluation of breast disease.
Breast Pathology, a title in the Foundations in Diagnostic Pathology series, provides all of the most essential information on the pathological entities encountered in practice in an easy-to-use format. Drs. Frances P. O'Malley, Sarah E. Pinder, and Anna Marie Mulligan provide unparalleled expert guidance for the study and diagnosis of a broad spectrum of breast lesions as well as the broad range of appearances of normal breast tissue. The consistent, practical format with a wealth of illustrations, at-a-glance boxes, and tables, make this title ideal for quick reference for both novices and experienced breast pathologists. Reference key information quickly and easily with a consistent, user-friendly format and at-a-glance boxes and tables throughout the text. Examine all aspects of a pathologic entity, including clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnosis, and prognostic and therapeutic considerations. Catch all the nuances of how pathological lesions present through over 400 full-color illustrations. Practice with confidence and overcome your toughest challenges with advice from the top minds in breast pathology. Apply the latest molecular diagnostic techniques to recognize newly identified classifications in breast disease. Get more of the information you need from new and expanded chapters covering a broad range of diseases and topics including fine needle aspiration cytology and the physical handling of core biopsy specimens; handling and evaluation of sentinel lymph nodes; diseases of the male breast; and state-of-the-art coverage of molecular advances in malignant breast disease. Prepare for the future of breast pathology with a new chapter dedicated to gene profiling and stem cell diagnostic techniques.
Focuses on the essential information needed by pathologists in order to be able to interpret breast lesions (tumors) appropriately. This book talks about the diagnostic criteria with systematic analysis of differential diagnoses. It also demonstrates value and limitations of immunohistochemistry as a diagnostic adjunct.
This book provides a concise, step-by-step guide to accurate microscopic diagnosis for clinicians who deal with patients with breast lesions. The emphasis is on a practical approach to dealing with breast biopsies and reaching a diagnosis. It outlines the procedures used for the microscopic diagnosis of various breast lesions and the significance of the nomenclature and terms used in pathology reports, including those dealing with uncommon or rare lesions. Ample illustrations of the lesions discussed are included, particularly those dealing with uncommon and border-line lesions. There is a special emphasis on breast cancer and on the fact that not all breast cancers are the same. The different ways by which breast cancers are classified are discussed including recent classifications which lead to personalized therapy. The book is aimed at pathologists of all grades who deal with breast biopsies including those in training. It would be also useful for practicing and trainee surgeons and oncologists as well as other health professionals dealing with patients with breast diseases and scientists carrying out research on breast problems.
This first of two volumes provides and in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The book is organised in themed parts exploring topics such as epidemiology, risk factors, genetic biomarkers, pathological evaluation of tumors and biopsy techniques. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.
Edited by two eminent authorities on breast pathology, this heavily illustrated text offers essential guidance on diagnostic evaluation of needle core biopsies. More than 1,100 full-color illustrations depict the entire spectrum of breast pathology seen in needle core biopsies.
Widespread use of mammography has resulted in detection of small cancers with favorable prognosis, as well as an array of indeterminate lesions, the majority of which turn out to be histologically benign. This book gives a detailed account of the radiology and pathology of screening-detected lesions, with discussion of risk assessment, to assist clinicians in the follow-up of their patients. Related lesions are dealt with in consecutive chapters, giving the reader an opportunity for comparison. The book is well illustrated with radiological and pathological correlation of mostly screening-detected images including mucoecele-like lesions and columnar lesions. Surgeons, radiologists, pathologists and breast care nurses will find the book highly useful for the management of patients with benign or indeterminate breast lesions in a multidisciplinary setting.
