Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.
This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
The new edition of Toward Speaking Excellence addresses the recent changes to the Test of Spoken English (TSE(R)). The text introduces readers to the format of the new TSE(R), typical questions, and scoring criteria. The second edition of Toward Speaking Excellence includes actual student responses that are used or modified to highlight specific characteristics of effective communication. Two complete sample TSE(R)-like tests are included for further practice. Also provided are practice with some of the skills that, while no longer tested on the TSE(R), are key to sounding more native-like and fluent. Toward Speaking Excellence may be used as an individual study tool or as a course text. While the material is directed toward the TSE(R) and SPEAK(R) tests, the communication strategies presented will prepare students for other types of oral exams (including the TAST(R), interviews, and performance tests. Toward Speaking Excellence is a course book but may also be used for individual test-preparation/self-study. Dean Papajohn is a Specialist in Education at the Center for Teaching Excellence, University of Illinois, Urbana-Champaign..
Atlas at War! collects fifty hard-hitting stories from Atlas Comics, the company that became Marvel Comics and published more war titles than anyone in the industry between the years 1951 and 1960. Comics historian Dr. Michael J. Vassallo has chosen the best of the best, many of which are coming back into print for the first time, from sixteen different Atlas war titles and featuring the artwork of twenty different artists--giants of the genre, including Russ Heath, John Severin, Bernie Krigstein, Joe Maneely, Jerry Robinson, Steve Ditko, and Jack Kirby. Each page has been meticulously restored from its first printing by comic art restorer Allan Harvey. Atlas at War! covers the brutal pre-code period where graphic depictions of war action were rendered by artists who were World War II veterans themselves, as well as the post-code period, where code restrictions forced creators to tell stories without graphic violence but produced some of the most beautiful comic art of the genre. In addition to the artists, stories cover all aspects of war--from famous campaigns, weaponry, and personal soldier stories to political topics, Nazi atrocities, and even one story tinged with pre-code horror! Often overlooked in favor of its competitors, Atlas at War! will finally show that Atlas' war titles were second to no one.
A fascinating examination of the world of private investigators by a 21st-century private eye. Today's world is complicated: companies are becoming more powerful than nations, the lines between public and corporate institutions grow murkier, and the internet is shredding our privacy. To combat these onslaughts, people everywhere -- rich and not so rich, in business and in their personal lives -- are turning away from traditional police, lawyers, and government regulators toward a new champion: the private investigator. As a private investigator, Tyler Maroney has traveled the globe, overseeing sensitive investigations and untying complicated cases for a wide array of clients. In his new book, he shows that it's private eyes who today are being called upon to catch corrupt politicians, track down international embezzlers, and mine reams of data to reveal which CEOs are lying. The tools Maroney and other private investigators use are a mix of the traditional and the cutting edge, from old phone records to computer forensics to solid (and often inspired) street-level investigative work. The most useful assets private investigators have, Maroney has found, are their resourcefulness and their creativity. Each of the investigations Maroney explores in this book highlights an individual case and the people involved in it, and in each account he explains how the transgressors were caught and what lessons can be learned from it. Whether the clients are a Middle Eastern billionaire whose employees stole millions from him, the director of a private equity firm wanting a background check on a potential hire (a known convicted felon), or creditors of a wealthy American investor trying to recoup their money after he fled the country to avoid bankruptcy, all of them hired private investigators to solve problems the authorities either can't or won't touch. In an era when it's both easier and more difficult than ever to disappear after a crime is committed, it's the modern detective people are turning to for help, for revenge, and for justice.
Many men killed Julius Caesar. Only one man was determined to kill the killers. From the spring of 44 BC through one of the most dramatic and influential periods in history, Caesar's adopted son, Octavian, the future Emperor Augustus, exacted vengeance on the assassins of the Ides of March, not only on Brutus and Cassius, immortalized by Shakespeare, but all the others too, each with his own individual story. The last assassin left alive was one of the lesser-known: Cassius Parmensis was a poet and sailor who chose every side in the dying Republic's civil wars except the winning one, a playwright whose work was said to have been stolen and published by the man sent to kill him. Parmensis was in the back row of the plotters, many of them Caesar's friends, who killed for reasons of the highest political principles and lowest personal piques. For fourteen years he was the most successful at evading his hunters but has been barely a historical foot note--until now. The Last Assassin dazzlingly charts an epic turn of history through the eyes of an unheralded man. It is a history of a hunt that an emperor wanted to hide, of torture and terror, politics and poetry, of ideas and their consequences, a gripping story of fear, revenge, and survival.
Want to make a big bet on an economic recovery in the U.S.? Start thinking small! The growing popularity of penny stocks can be attributed to a combination of increased understanding and tough economic times.??Penny Stocks For Dummies explains the basics of penny stocks and provides expert guidance to help you get involved right away. Penny Stocks For Dummies provides you with the information and advice you need before considering an investment in penny stocks, as well as the tools needed to make sound investments. You'll also get expert guidance on identifying growth trends and market sectors positioned for rapid growth, finding undiscovered penny stocks, and understanding the fundamentals of a potential investment in penny stocks. Arms you with the know-how to properly identify, and purchase, winning penny stocks Shows you how good money can be made from these low-priced shares Gets you involved in Penny Stocks quickly, painlessly, and on a small budget Penny Stocks For Dummies appeals to anyone who doesn't have a lot to invest right now in the current economic climate, but who wants to multiply what they do have.
Oversight of the Department of Justice : hearing before the Committee on the Judiciary, House of Representatives, One Hundred Fourteenth Congress, second session, July 12, 2016.
One of the New York Times' 20 Books to Read in 2020 "A tonic . . . Splendid . . . A respite . . . A summer cocktail of a book."--Washington Post "Unforgettable . . . Behind her brilliantly witty and uplifting message is a remarkable vulnerability and candor that reminds us that we are not alone in our struggles--and that we can, against all odds, get through them."--Lori Gottlieb, New York Times best-selling author of Maybe You Should Talk to Someone Part memoir and part joyful romp through the fields of imagination, the story behind a beloved pseudonymous Twitter account reveals how a writer deep in grief rebuilt a life worth living. Becoming Duchess Goldblatt is two stories: that of the reclusive real-life writer who created a fictional character out of loneliness and thin air, and that of the magical Duchess Goldblatt herself, a bright light in the darkness of social media. Fans around the world are drawn to Her Grace's voice, her wit, her life-affirming love for all humanity, and the fun and friendship of the community that's sprung up around her. @DuchessGoldblat (81 year-old literary icon, author of An Axe to Grind) brought people together in her name: in bookstores, museums, concerts, and coffee shops, and along the way, brought real friends home--foremost among them, Lyle Lovett. "The only way to be reliably sure that the hero gets the girl at the end of the story is to be both the hero and the girl yourself." -- Duchess Goldblatt
In this inspiring biography, discover the true story of Harriet the Spy author Louise Fitzhugh -- and learn about the woman behind one of literature's most beloved heroines. Harriet the Spy, first published in 1964, has mesmerized generations of readers and launched a million diarists. Its beloved antiheroine, Harriet, is erratic, unsentimental, and endearing -- very much like the woman who created her, Louise Fitzhugh. Born in 1928, Fitzhugh was raised in segregated Memphis, but she soon escaped her cloistered world and headed for New York, where her expanded milieu stretched from the lesbian bars of Greenwich Village to the art world of postwar Europe, and her circle of friends included members of the avant-garde like Maurice Sendak and Lorraine Hansberry. Fitzhugh's novels, written in an era of political defiance, are full of resistance: to authority, to conformity, and even -- radically, for a children's author -- to make-believe. As a children's author and a lesbian, Fitzhugh was often pressured to disguise her true nature. Sometimes You Have to Lie tells the story of her hidden life and of the creation of her masterpiece, which remains long after her death as a testament to the complicated relationship between truth, secrecy, and individualism.
